The Dutcher Lab published three noteworthy papers in the latter half of 2019. The first paper, “De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry,” appears in the American Journal of Human Genetics and demonstrates that FoxJI, a transcription factor for cilia genes, show haplo-insufficiency and causes primary ciliary dyskinesis.
Another paper, “Structure of the Decorated Ciliary Doublet Microtubule,” was done in collaboration with Dr. Rui Zhang in the Department of Biochemistry at WashU and Dr. Alan Brown at Harvard. Researchers used cyro-EM to identify the protein in the middle of microtubules. The study appears in Cell.
A third paper, “Asymmetries in the cilia of Chlamydomonas,” was penned by Dr. Susan Dutcher for the Royal Society.