Be sure to check out these recently published articles:

  • Congrats to Kelsey Krus (DiAntonio/Milbrandt labs) on her paper demonstrating that loss of STMN2 in mice induces slowly progressive motor deficits, a cardinal feature of ALS.
  • Exciting work from the DiAntonio & Milbrandt labs on the role of Sarm1’s NADase activity in cell signaling at the fly NMJ (and the companion paper from @HTB_soFLY on dSarm1 signaling in glia).
  • New bioarchive paper out of the MIlbrandt and DiAntonio labs demonstrates that loss of SARM1 leads to dramatic suppression of axonal, synaptic, and mitochondrial defects in a model of CMT2A peripheral neuropathy.
  • Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, Di Antonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol Cell. 2022 Mar 18;. doi: 10.1016/j.molcel.2022.03.007. [Epub ahead of print] PubMed PMID: 35334231; NIHMSID:NIHMS1792716.
  • Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol. 2022 Feb 7;221(2). doi: 10.1083/jcb.202106080. Epub 2021 Dec 22. PubMed PMID: 34935867; PubMed Central PMCID: PMC8704956.
  • Yim AKY, Wang PL, Bermingham JR Jr, Hackett A, Strickland A, Miller TM, Ly C, Mitra RD, Milbrandt J. Disentangling glial diversity in peripheral nerves at single-nuclei resolution. Nat Neurosci. 2022 Feb;25(2):238-251. doi: 10.1038/s41593-021-01005-1. Epub 2022 Feb 3. PubMed PMID: 35115729; NIHMSID:NIHMS1791514.