The Dougherty Lab has a new preprint, “TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo.” The work was done in collaboration with the Lawson Lab. Yating Liu, a...
Tomás Lagunas Jr., a graduate student in the Dougherty Lab, will be giving an oral presentation and was awarded the registration scholarship for the 2020 Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) virtual conference....
The Wang Lab recently published a new paper in Science Advances, “Cellular diversity of the regenerating caudal fin.” Yiran Hou, a graduate student in the lab, is first author on the paper. Ting Wang, Professor of Genetics, Professor of Computer Science...
The Wang Lab has a new preprint, “Transcript assembly improves expression quantification of transposable elements in single cell RNA-seq data.” Wanqing Shao, a postdoc in the lab, is first author on the preprint. Ting Wang, PhD, Professor of Genetics,...
Zongtai Qi, a former graduate student in the Mitra Lab, is an author on a paper which was recently accepted in Molecular Biology and Evolution entitled, “Human L1 Transposition Dynamics Unraveled with Functional Data Analysis” in a collaboration led by the...
The Mitra Lab recently published a paper in Cell, “Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cell.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author on the paper....
Bernie Mulvey, a graduate student in the Dougherty Lab, received an extremely generous travel award to remotely attend the 2020 American College of Neuropsychopharmacology conference, and to attend the 2021 ACNP conference in person. Congratulations, Bernie!
Kelli McFarland White has joined the Dougherty Lab as research lab supervisor. Kelli will work closely with Darshan Sapkota, a postdoc in the lab, on research, and also take on an organizational role to make operations in the molecular lab as efficient as possible....
The DiAntonio and Milbrandt Labs published a paper in the Journal of Cell Biology, “SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.” Kwang Woo Ko, a postdoc in the DiAntonio Lab, is lead author on the...
The Wang Lab and Dougherty Lab published a paper recently in Science Advances, “DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods.” Yu He, a former graduate student in the...
Chengran Yang, a former graduate student in the Dougherty Lab, is lead author on a new preprint, “Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traits.” Congratulations, Chengran!
The Buchser, DiAntonio, and Milbrandt Labs have published a paper in Scientific Data, “Domain-centric database to uncover structure of minimally characterized viral genomes.” Jack Bramley, a lead scientist in the Buchser Lab, is lead author on the paper. ...
The McDonnell Genome Institute, researchers at WashUMed, and Fluidigm have developed an extraction-free saliva-based test to detect the SARS‑CoV‑2 virus. It has an easy-to-administer protocol that does not require collection via a nasopharyngeal swab. “Rapid, reliable...
The Dougherty Lab recently published a paper in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants across Biological Contexts.” Bernie Mulvey, a graduate student in the lab, is first author. Tomás...
Scott Lee, an undergraduate researcher in the Dougherty Lab, will be leaving this fall to work at The Jackson Laboratory in a very competitive MSTP post-bacc fellowship. Congratulations, Scott!
The Dougherty Lab published a paper in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences.” Nathan Kopp, a former graduate student in the lab, and Kayla...
The Turner Lab recently published its first paper, “Precise breakpoint detection in a patient with 9p– syndrome,” in the Cold Spring Harbor Molecular Case Studies journal. Lead authors include Jeffrey Ng, a bioinformatics research analyst in the lab, and...
The Dutcher Lab has published a paper in collaboration with researchers at the MRC Laboratory of Molecular Biology, Cambridge. The paper, “CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions,” appears in a recent issue of Structure. Takashi...
Zach Payne, a graduate student in the Molecular Genetics and Genomics program at Washington University School of Medicine, will be a joint student in the Turner and Dutcher Labs to look at cilia and autism. Welcome, Zach!
Pam Recio and Lori Llaci have joined the Mitra Lab as graduate students. Pam received a Bachelor of Science in Molecular Biology from California State University Monterey Bay. Her undergraduate research involved assessing the role that specific genes-LAC1 and LAG1-...
A special thank you to Matt Lalli, a postdoc in the Mitra and Milbrandt Labs, Xuhua Chen, the lab manager in the Mitra Lab, Josh Langmade, a staff scientist in the Mitra Lab, and Michael Wilkinson, a graduate student in the Mitra Lab, who worked throughout the...
Arnav Moudgil, a graduate student in the Mitra Lab, has a new preprint, “The qBED track: a novel genome browser visualization for point processes.” Moudgil is a first author and Ting Wang, PhD, the Sanford and Karen Loewentheil Distinguished Professor of...
Ryan Friedman, a graduate student in the Cohen Lab, recently got an F31 Fellowship from the National Human Genome Research Institute to continue his work applying active machine learning and synthetic biology to better understand non-coding sequences. Congratulations,...
The Dutcher Lab has a new paper published in Nature, “Mapping and characterization of structural variation in 17,795 human genomes.” Haley J Abel, PhD, Instructor in Genetics at Washington University School of Medicine, is first author on the paper. Susan...
The Milbrandt Lab recently had a paper published in Nature Communications, “Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia.” Peter Wang and Aldrin K. Y. Yim, graduate students in the lab, are...
The Lawson Lab has a new preprint, “Spontaneous restoration of functional β-cell mass in obese SM/J mice.” Alex Miranda, a graduate student in the Lawson Lab, is first author on the preprint. Heather Lawson, PhD, Assistant Professor in the Department of...
The Lawson Lab recently published a paper in Physiological Genomics, “Genetic background and diet affect brown adipose gene co-expression networks associated with metabolic phenotypes.” Caryn Carson, a graduate student in the lab, is first author on the...
Susan Maloney, PhD, a member of the Dougherty Lab, was recently promoted to Assistant Professor in Psychiatry at Washington University School of Medicine. Congratulations, Dr. Maloney!
The Stormo Lab has a new preprint, “Autoregulation of Many Yeast Ribosomal Proteins Discovered by Efficient Search for Feedback Regulation.” Basab Roy, a postdoc in the lab, is first author on the preprint. Gary Stormo, PhD, the Joseph Erlanger Professor...
The Milbrandt Lab and the Mitra Lab and scientists at the McDonnell Genome Institute have a new preprint, “Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP.” Matt Lalli, a postdoc in the Milbrandt and Mitra Labs, is a...
The Milbrandt and DiAntonio Labs have a new preprint, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
The Department of Genetics at Washington University School of Medicine and the McDonnell Genome Institute’s WashU SEPA program, an NIH-funded science outreach project, is helping to provide food items to St. James AME Church during the coronavirus pandemic. The...
The Dougherty Lab published a new paper in Brain and Behavior, “The trajectory of gait development in mice.” Shyam Akula, a former undergraduate researcher in the lab, is first author on the paper. Joe Dougherty, PhD, Associate Professor of Genetics at...
Caryn Carson, a graduate student in the Lawson Lab, recently won first place in the Developmental Biology, Genetics, and Immunology category in the 2020 AAAS Student E-poster Competition. Congratulations, Caryn!
The Dougherty Lab recently had a paper published in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences.” Nathan Kopp, PhD, a former graduate student in the...
Jelani Deajon-Jackson, an undergraduate student in the Dougherty Lab, was recently awarded a BioSURF fellowship by Washington University in St. Louis to train with his mentor Mike Vasek, a postdoc in the lab. The Washington University Biology Summer Undergraduate...
Shyam Akula, a Dougherty Lab alum and a graduate student in the MSTP program at Harvard/MIT recently received a Paul & Daisy Soros Fellowship. Congratulations, Shyam! Read more about him and the fellowship here.
Jeffrey Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics, and colleagues including William G. Powderly, MD, the J. William Campbell Professor of Medicine and director of the Institute for Clinical and Translational Sciences...
The Dougherty and Mitra Labs had a paper published in PNAS, “A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues.” Alex Cammack, a graduate student in the Miller Lab who recently defended, is first author on the paper....
By Jim Skeath, PhD, Professor of Genetics at Washington University School of Medicine I’ve always felt that the keys to success in graduate school are to work hard and have fun – to work hard, think hard, do experiments, and to enjoy what you do and where you do it. I...
The Dougherty Lab has a new preprint, “Activity-dependent translation in astrocytes.” Darshan Sapkota, a postdoc in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor in the Department of Genetics at Washington University...
The Milbrandt Lab has a new paper in PNAS, “Cell-autonomous expression of the acid hydrolase galactocerebrosidase.” The paper is in collaboration with the Sands Lab and the Bruno Benitez, PhD, Assistant Professor in Psychiatry at Washington University...
The Skeath Lab recently had a paper published in eLife, “Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS.” Haluk Lacin, PhD, a member of the lab, is first author on the paper, and Jim Skeath, Professor...
Susan Dutcher, PhD, professor of Genetics, Cell Biology and Physiology, Moe Mahjoub, PhD, assistant professor of Medicine (Division of Nephrology), Cell Biology and Physiology, and Steven Brody, MD, the Dorothy R. and Hubert C. Moog Professor of Pulmonary Medicine,...
Christy Hoffmann, a graduate student in the Morris Lab, was recently awarded a fellowship the National Science Foundation Graduate Research Fellowship Program. The program “recognizes and supports outstanding graduate students in NSF-supported science,...
Sheng Chih (Peter) Jin, PhD, Assistant Professor in the Department of Genetics at Washington University School of Medicine, was recently awarded an NIH grant for his project, “Integrative Genomic Analysis of Congenital Heart Disease.” Congratulations, Dr....
The Wang Lab recently had a paper published in Nature, “A genomic and epigenomic atlas of prostate cancer in Asian populations.” Hyung Joo Lee, a postdoc in the lab, is a first author on the paper. Ting Wang, Professor of Genetics, Professor of Computer...
The Dougherty Lab recently had a paper published in Scientific Reports, “CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system.” Yating Liu, a programmer in the lab, is an author on the paper,...
Washington University School of Medicine researchers are tackling the coronavirus pandemic, and Ting Wang, the Sanford and Karen Loewentheil Distinguished Professor of Medicine, and his lab are getting in on the effort. The lab built a genome browser to help...
The Cohen Lab recently had a paper published in eLife, “Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells.” Dana King, PhD, previously a graduate student in the Cohen Lab, is first author on...
The Mitra Lab has a new paper published in Nucleic Acids Research, “Quantitative analysis of transcription factor binding and expression using calling cards reporter arrays.” Jiayue Liu, a graduate student in the lab, is first author on the paper....
The Dougherty Lab has a new preprint, “CRISPR-TRAPSeq identifies the QKI RNA binding protein as important for astrocytic maturation and control of thalamocortical synapses.” Kristina Sakers, PhD, a former graduate student in the lab, is first author on the...
The Dougherty Lab has a new preprint in collaboration with Dionnet Bhatti’s lab at Harvard. The preprint, “Extended amygdala-parabrachial circuits alter threat assessment to regulate feeding,” includes authors Bernie Mulvey, a grad student in the...
The Dougherty Lab has a new paper in Neural Development, “An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells.” Darshan Sapkota, a postdoc in the lab, is first author on the paper. Joe Dougherty, PhD,...
Samantha Morris, PhD, Assistant Professor of Genetics and Developmental Biology at Washington University in St. Louis, and Allen Distinguished Investigator, recently joined Development as an associate editor. Morris’s appointment comes as the journal responds to...
The Wang Lab has a new paper published in Genome Biology, “Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility.” Hyung Joo Lee, a postdoc in the lab, is first author on the...
The Milbrant Lab has a new paper published in Experimental Neurology, “cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at...
Tomás Lagunas, Jr., and Bernie Mulvey, graduate students in the Dougherty Lab, recently added a preprint edition review of their MPRA technique for use in neuropsychiatric genetics to Biorxiv. Congratulations, Tomás and Bernie!
The Morris Lab has two new preprints: The first, “Capybara: A computational tool to measure cell identity and fate transitions,” includes first author Wenjun Kong, a graduate student in the lab; Yuheng Fu, an undergraduate student in the lab; and Samantha...
The Dougherty Lab recently welcomed new members including Rachael, a senior graduate student who will be working with Kayla Nygaard, a graduate student in the lab; Chayla, a first year PhD rotation student working with Bernie Mulvey, a graduate student in the lab;...
The Wang Lab had a paper published recently in eLife, “Derivation of trophoblast stem cells from naïve human pluripotent stem cells.” Authors include Xiaoyun Xing, a staff scientist in the Wang Lab; Ting Wang, PhD, Professor of Genetics, Professor of...
Samantha Morris, Assistant Professor of Genetics and Developmental Biology at Washington University School of Medicine, was named a 2020 Sloan Research Fellow. The fellowship honors scholars in the U.S. and Canada “whose creativity, leadership, and independent...
The Wang Lab has a new preprint, “Exploring the coronavirus epidemic using the new WashU Virus Genome Browser.” The preprint focuses on the new WashU Virus Genome Browser, a web-based portal for viewing virus genomic data. The browser houses 16 complete...
The Wang Lab has released a new WashU Virus Genome Browser. “In addition to several included data tracks, the browser supports user-uploaded sequences, as well as two visualization platforms: a genomic track view and a phylogenetic tree view,” the lab said...
The Dougherty Lab has a new preprint, “The Oft-Overlooked Massively Parallel Reporter Assay: Where, When, and Which Psychiatric Genetic Variants are Functional?” Bernie Mulvey, a graduate student in the lab, is first author on the preprint. Tomás Lagunas...
Tychele Turner, PhD, Assistant Professor of Genetics at Washington University School of Medicine, recently won the 2019 Human Genetics SMRT Grant from Pacific Biosciences. Congratulations, Dr. Turner! Read more about Dr. Turner and her work in this Q&A with...
Susan Dutcher, Ph.D., Professor in the Department of Genetics at Washington University, has published two reviews, one on the structure of cytoplasmic dynein and the other on Hydin, a protein in the central pair microtubules. “Dynein tails: how to hitch a ride...
The Dutcher Lab published three noteworthy papers in the latter half of 2019. The first paper, “De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry,” appears in the American Journal of...
Mayank Choudhary, a graduate student in the Wang Lab, had a paper published recently in Genome Biology. The paper, “Co-opted transposons help perpetuate conserved higher-order chromosomal structures,” shows that transposable elements heavily contribute to...
The Morris Lab has a new preprint with the Solnica-Krezel Lab, “High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human embryonic stem cell gastruloid cultures.” Read more about the preprint and the authors...
Susan Dutcher, Ph.D., Professor of Genetics at Washington University School of Medicine in St. Louis, was recently elected to serve on the Council of Councils for the American Association for the Advancement of Sciences (AAAS). Congratulations, Dr. Dutcher!
Erica Pehrsson, a postdoc in the Wang Lab, is making waves with her recent paper, “The epigenomic landscape of transposable elements across normal human development and anatomy,” which was published in Nature Communications in December 2019. The paper...
Josh Jang, a graduate student in the Wang Lab, and Nakul Shah, a medical student in the Wang Lab, recently had their paper selected as one of the “2019 Papers of the Year” by NIH’s National Institute of Environmental Health Sciences. The paper,...
The Milbrandt Lab has a new preprint, “Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming.” Peter Wang, a postdoc in the lab, is first author on the preprint. Aldrin Yim, a graduate student in the lab, is also...
The Lawson Lab has a new preprint, “Genetic background and diet affect brown adipose gene co-expression – metabolic associations.” Caryn Carson, a graduate student in the lab, is first author on the preprint. Heather Lawson, Ph.D., Assistant Professor in...
The Wang Lab published a paper recently in Nature Communications, “The epigenomic landscape of transposable elements across normal human development and anatomy.” Erica Pehrsson, a postdoc in the Wang Lab, is first author on the paper. Mayank Choudhary and...
The Dougherty Lab had a paper published recently in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models,” thoroughly defines a set of...
The Province Lab and the Long Life Family study got a $68 million NIH grant to investigate what contributes to extreme longevity. Michael A. Province, Ph.D., professor of genetics at Washington University School of Medicine, is the principal investigator on the...
The Milbrandt Lab published a paper recently in Glia. The paper, “Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy,” shows that Schwann cells may play an important role in diabetic neuropathy and targeting...
The Milbrandt Lab had a paper published recently in Molecular Neurobiology. The paper, “DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration,” was published in...
Gary Stormo, Ph.D., Joseph Erlanger Professor in the Department of Genetics and the Center for Genome Sciences and Systems Biology at Washington University School of Medicine, recently was honored with the Carl and Gerty Cori Faculty Achievement Award. Dr. Stormo,...
Samantha A. Morris, Ph.D., Assistant Professor of Developmental Biology and Genetics at Washington University School of Medicine in St. Louis, was recently named an Allen Distinguished Investigator by The Paul G. Allen Frontiers Group of the Allen Institute. Morris,...
The Schedl Lab has a new preprint, “GLP-1 Notch – LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1.” Jian Chen, a postdoctoral researcher in the lab, is first author on the preprint. Tim Schedl,...
Jeff Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at Washington University School of Medicine in St. Louis, was recently honored with a Distinguished Faculty Award at Washington University’s annual...
The Morris Lab, in collaboration with the Warner Lab at Washington University School of Medicine in St. Louis, recently published a paper in CMGH. The paper, “Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection...
The Dutcher Lab had a paper published recently in Cell. The paper, “Structure of the Decorated Ciliary Doublet Microtubule,” explains the architectural principles that underpin the assembly of the native axonemal doublet microtubule and provides a...
Graduate students in the Department of Genetics at Washington University School of Medicine won awards at the recent MGG/CSB/HSG annual retreat. Clarice Hong from the Cohen Lab, Robert Chen from the Gordon Lab, and Celine St. Pierre from the Lawson Lab won “Best...
Celine St. Pierre, a graduate student in the Lawson Lab, was recently awarded best presentation at the 2019 MGG/CSB/HSG retreat. Congratulations, Celine!
The Dougherty Lab recently presented at the annual Society for Neuroscience meeting in Chicago. Dr. Susan Maloney, Instructor in Psychiatry and a member of the Dougherty Lab, presented on modeling social motivation in the mouse and the role of Shank3B and the oxytocin...
Samantha Morris, Ph.D., Assistant Professor of Developmental Biology and Genetics at Washington University School of Medicine in St. Louis, recently published an article in Nature. The article, “Cell identity reprogrammed,” focuses on John Gurdon’s...
The Genome Technology Access Center at the McDonnell Genome Institute (GTAC@MGI) at Washington University School of Medicine in St. Louis is teaming up with PercayAI, a recently-launched augmented intelligence software company, to create technology that can accelerate...
The Dutcher Lab has a new preprint, “Mutation of CFAP57 causes primary ciliary dyskinesia by disrupting the asymmetric targeting of a subset of ciliary inner dynein arms.” Mathieu Bottier, a postdoc in the Dutcher Lab, and Mihaela Stoyanova, a technician...
The McDonnell Genome Institute (MGI) at Washington University School of Medicine and its institutional partners recently got $29.5 million in NIH funding for two new genome sequencing centers that allow scientists to generate and maintain the most comprehensive...
The Dougherty Lab has new preprint on the trajectory of gait development in mice. The preprint includes first author Shyam Akula, a graduate student at Harvard Medical School, and senior authors Joseph Dougherty, Ph,D., Associate Professor of Genetics at Washington...
Reshma Bhagat has joined the Dougherty Lab as a postdoc. Dr. Bhagat comes from a background studying molecular perturbations in neural cell types elicited by Zika virus components. Check out Dr. Bhagat’s work here.
Jeffrey Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at Washington University School of Medicine, is a senior author on a new paper from the DiAntonio Lab recently published in JCI Insight. The paper,...
