Spring 2017

COURSE OBJECTIVES Bio5491 – Advanced Genetics provides an overview of basic concepts and techniques in genetics and their use in answering fundamental questions in biology. The lectures focus primarily on studies carried out in yeast, C. elegansDrosophila, mouse, and humans to illustrate the power of genetics as an experimental tool.

FORMAT OF THE COURSE

  • We have two lectures per week plus a discussion group or a Special Topics lecture on Monday. Class meets Tuesday/Thursday 1:30-3:00 in 4001B McKinley Research Building. First day of class is January 17 and last day of class is April 11.
  • On Mondays we either have a discussion group similar to those for MCB and Nucleic Acids or a Special Topics Lecture. Special Topics lectures are from 12:00-1:00 in 4001B McKinley Research Building. The time and place for the individual discussion groups vary and will be determined the second week of class.
  • Thursdays after class at 3:00, your TA will be available for questions on homework or course material.
  • The major project for the course is to write an NIH style post-doctoral fellowship proposal. Abstracts and Specific Aims of the proposal are due March 20. The proposal is due by 12:00 NOON on Monday, May 1. Study Sections will be held on May 8,9&10 from 1:00-4:00 pm. Each student is required to attend their one assigned study section. Each student will be given two proposals for a particular Study Section and that student is required to read and to provide a written and oral critique of both proposals at the Study Section.

SCHEDULE          

  • If you have difficulty accessing any links below or find errors, please contact Yang Li at li777@wustl.edu
  • Please refer to updated schedules for problem set due dates.
Date Topic Lecturer Papers/Notes
Jan 17 Tue Introduction C. elegans genetics Tim Schedl Kerry Kornfeld Intro Readings:

Reading for Kornfeld lecture:

Notes:

Readings for first homework, due Jan 23:

Jan 19 Thu C. elegans genetics Tim Schedl Readings for Schedl lecture:

Notes:

Schedl lecture #1 Genetic approaches

Jan 23 Mon

12:00pm

Review of Genetic Principles Yang Li

#1 Homework Due

(You can either send your homework to TA through email( li777@wustl.edu) or give a hard copy on Monday to your TA.)

Jan 24 Tue C. elegans Genetics Tim Schedl Readings for Schedl lecture:

Notes:

Part of this lecture will need the slides for Prof. Schedl’s first C. elegans lecture Schedl lecture #1 Genetic approaches

Schedl lecture #2 Reverse Genetics

Jan 25 Wed

4:00pm

Research Proposals

Rm 426, McDonnell Science Building

Tim Schedl Reading:

lin28RegulationNSRA.Proposal

Notes:

Proposal guide

Proposal lecture

Jan 26 Thu C. elegans Genetics Tim Schedl  Notes:

Schedl lecture #3 Genetic Pathway

Schedl lecture #4 Cell Autonomy

Nomenclature_C.elegans

Readings and Homework:

HW_schedl (Due Feb.28)

Growth_inhibitor

C.elegans_model_human

Jan 31 Tue C. elegans Genetics Kerry Kornfeld  Notes:

Kornfeld Lecture #2

Homework and readings:

HW_Kornfeld (Due Feb. 16)

Feb 2 Thu Drosophila Genetics Jim Skeath Reading Guide for Drosophila Lectures:

Drosophila General Background Reading: 

Lecture I Reading:

Notes:

Skeath_1_slides

Skeath_1_note

fly_nomenclature

Feb 6 Mon Discussion section: Research Proposals small groups Discussion Reading:

Reminder: write the critique for the readings.

Feb 7 Tue Drosophila Genetics Jim Skeath  Lecture II Reading: 

Notes:

Skeath_2_slide

Skeath_2_notes

Feb 9 Thu Drosophila Genetics Jim Skeath  Lecture III Reading: 

Notes:

Skeath_3_slide

Skeath_3_notes

Feb 13 Mon Discussion Section small groups Discussion Reading:

Feb 14 Tue Drosophila Genetics Jim Skeath  Lecture IV Reading:  

Notes:

Skeath_4_slide

Skeath_4_notes

Drosophila Problem Set : (Due Mar. 28th)

Feb 16 Thu Yeast Genetics Susan Dutcher  Reminder:Kornfeld HW due

Notes:

Dutcher_1

Yeast_nomenclature

Feb 20 Mon Discussion Section small groups  Discussion Reading:

Feb 21 Tue Yeast Genetics Susan Dutcher  Notes:

Dutcher_2

Feb 22 Wed*

4:00pm
Plant Genetics Lucia Strader Note: 

Plant Genetics

Feb 23 Thu Yeast Genetics Susan Dutcher  Note:

Dutcher_3

Homework:

Dutcher_HW (DUE Apr. 4th)

Feb 27 Mon

12:00pm

Yeast two-hybrid and related screens Yang Li Discussion Reading:

Macromolecular interaction 

Homework:

Y2H (Due Feb27 12pm, you can either email me or hand in during the lecture)

Critiques are NOT required for this paper.

Notes:

Y2H

 Feb 28 Tue High Throughput Genetics Tim Schedl  Reminder: Schedl HW due

Notes: 

Lecture Readings:

Mar 2 Thu Zebrafish Genetics Kelly Monk Notes: 

Readings:

Mar 6 Mon Discussion Section small groups  Discussion Reading:

Mar 7 Tue Mouse Genetics Heather Lawson  Notes:

Heather_1

Nomenclature_Mouse

Mar 9 Thu Mouse Genetics Heather Lawson  Notes:

Heather_2

SPRING BREAK – MARCH 12-18
Mar 20 Mon Epigenetic & Cancer  Yang Li Notes:

Epi_can

Abstract and Specific Aims Due Email to: advancedgenetics@genetics.wustl.edu by 6PM

Mar 21 Tue Quantitative Genetics Heather Lawson  Notes:

Quantitative_1

Mar 23 Thu Quantitative Genetics Heather Lawson  Notes:

Quantitative_2

Mar 27 Mon Discussion Section Small groups  Discussion Reading:

Mar 28 Tue Human Genetics Christina Strong  Reminder: Drosophila HW due.

Notes:

Human_Genetics

Mar 30 Thu Human Genetics Joe Dougherty  Notes:

Neuro

Apr 3 Mon Discussion Section Small groups  Discussion Reading:

Apr 4 Tue Human Genetics Nancy Saccone  Reminder: Yeast HW Due.

Notes:

Saccone_1

Apr 10 Mon Present you Aims to the Discussion Section Small Groups  
Apr 11 Tue Human Genetics Nancy Saccone  Notes:

Saccone_2

Homework:

Human_genetics (Due Apr. 13th)

Apr. 13 Thu Human Genetics Nancy Saccone  Reminder: Human Genetics Due

Notes

Saccone_3

May 1 Mon
Research Proposals due Monday, May 1nd at 12:00 NOON (No Exceptions).
Email the Proposal to: advancedgenetics@genetics.wustl.edu
May 2 Tue Meet in McKinley 4001 at 1:30pm for Info Session on Study Sections. Grants returned for review.

Critique_samples

scoring

Critique_instruction

May 8, 9, 10 (Mon, Tues, Wed) Study Sections: 1-4pm (must attend on your one assigned day)