Wang Lab contributes to two papers

The Wang Lab has contributed to two new papers. The first, “Epigenetic therapies in ovarian cancer alter repetitive element expression in a TP53-dependent manner,” was recently published in Cancer Research. The second, “OCT4 cooperates with distinct...

Cohen Lab has a new preprint

The Cohen Lab has a new preprint, “A Test of the Pioneer Factor Hypothesis.” Jeff Hansen, a grad student in the lab, is lead author. Congratulations, all!

Lawson Lab has a new preprint

The Lawson Lab has a new preprint, “Parent-of-origin effects propagate through networks to shape metabolic traits.” Congratulations, all!

Dougherty Lab has paper published in Translational Psychiatry

The Dougherty Lab had a paper published in Translational Psychiatry, “Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.” Bernie Mulvey, a grad student in the lab, is lead author on...

Lawson Lab has new preprint

The Lawson Lab has a new preprint, “Integrated transcriptomics identifies β-cell subpopulations and genetic networks associated with obesity and glycemic control in SM/J mice.” Congratulations, all!

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process.” Congratulations, all!

Turner Lab has a new preprint

The Turner Lab has a new preprint, “ACES: Analysis of Conservation with Expansive Species.” Congratulations, all!

Cohen Lab collaborates on new preprint

The Cohen Lab collaborated with the Rubin Lab on a new preprint, “p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis.” Nathan Rockwell, a grad student in the Rubin Lab, is lead author on the preprint. Congratulations, all!

Mollah Lab has a new preprint

The Mollah Lab has a new preprint, “NeTOIF: A Network-based Approach for Time-Series Omics Data Imputation and Forecasting.” Min Shi, a postdoc in the lab, is lead author on the preprint. Congratulations, all!

Turner Lab has new preprint

The Turner Lab has a new preprint, “de novo variant calling identifies cancer mutation profiles in the 1000 Genomes Project.” Congratulations, all!

Cohen Lab has a new preprint

The Cohen Lab has a new preprint, “Modular effects of gene promoters and chromatin environments on noise in gene expression.” Siqi Zhao, a graduate student in the lab, is lead author on the preprint. Congratulations, all!

Wang Lab publishes a paper in Communications Biology

The Wang Lab published a paper in Communications Biology, “Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis.” Jennifer Flynn, a graduate student in the lab, is lead...

Mitra Lab has a new preprint

The Mitra Lab has a new preprint, “Measuring Transcription Factor Binding and Gene Expression using Barcoded Self-Reporting Transposon Calling Cards and Transcriptomes.” Matt Lalli, a former postdoc in the Mitra Lab, is lead author on the preprint....

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Functional connectivity of the developing mouse cortex.” Rachel Rahn, a graduate student in the lab, is lead author. Congratulations, all!

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model.” Kayla Nygaard, a graduate student in the lab, is lead author on the preprint. Congratulations, all!

Dougherty Lab publishes a new paper

The Dougherty Lab has a new paper published in the Journal of Neurodevelopmental Disorders, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint....

Buchser Lab has a new preprint

The Buchser Lab has a new preprint, “Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen.” Lead authors include Alex Yenkin, a research technician in the lab, and Jack Bramley, a staff scientist in the lab....

Cohen Lab has a new preprint

The Cohen Lab has a new preprint, “Genomic environments scale the activities of diverse core promoters.” Authors include graduate student Clarice Hong and Barak Cohen, PhD, Professor of Genetics and the Alvin Goldfarb Distinguished Professor of...

Jin Lab publishes paper in Star Protocols

The Jin Lab published a paper in Star Protocols, “Analysis workflow to assess de novo genetic variants from human whole-exome sequencing.” Grad students Spencer King and Sam Peters are authors. Sheng Chih (Peter) Jin, PhD, Assistant Professor of Genetics...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint. David Gutmann, MD, PhD, Director, Washington...

Dougherty Lab publishes a paper in Nature Communications

The Dougherty Lab published a paper in Nature Communications, “Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.” Lead author is Kristina Sakers, PhD, a former graduate student in the...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays.” Bernie Mulvey, a grad student in the lab, is first author. Joe Dougherty, PhD, Associate...

Dougherty Lab contributes to new paper in Science Advances

The Dougherty Lab contributed to a new paper published in Science Advances, “Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.” Andrew Luskin, a former graduate student in the Department of Anesthesiology at Washington...

Morris Lab contributes to paper published in Developmental Cell

The Morris Lab contributed to a new paper published in Developmental Cell, “Localized EMT reprograms glial progenitors to promote spinal cord repair.” Dana Klatt Shaw, PhD, a postdoc in the Mokalled Lab at Washington University School of Medicine, is lead...

Dougherty Lab has a new paper in Behavioral Neuroscience

The Dougherty Lab has a new paper in Behavioral Neuroscience, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, Assistant Professor of Pediatrics at...

Cohen Lab has a new preprint

The Cohen Lab has a new preprint, “Information Content Differentiates Enhancers From Silencers in Mouse Photoreceptors.” Ryan Friedman, a graduate student in the lab, is lead author on the preprint. Barak Cohen, PhD, Professor of Genetics and the Alvin...

Pincus Lab publishes a paper in eLife

The Pincus Lab published a paper in eLife, “Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans.” Holly Kinser, a former grad student in the lab, is lead author on the paper. Zach Pincus, PhD, Assistant...

Dougherty Lab postdoc has a new preprint

Mike Vasek, a postdoc in the Dougherty Lab, has a new preprint, “Microglia perform local protein synthesis at perisynaptic and phagocytic structures.” Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of...

Samantha Morris publishes a new perspective piece in Cell Stem Cell

Samantha Morris, PhD, Assistant Professor of Genetics and Developmental Biology at Washington University School of Medicine, recently collaborated on a perspective piece published in Cell Stem Cell, “Computational Stem Cell Biology: Open Questions and Guiding...

Wang Lab publishes paper in Genome Research

The Wang Lab published a paper in Genome Research, “Epigenomic differences in the human and chimpanzee genomes are associated with structural variation.” Xiaoyu Zhuo, a postdoc in the lab, is leader author on the paper. Ting Wang, PhD, Professor of...

Wang Lab publishes paper in Genome Research

The Wang Lab published a paper in Genome Research, “Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data.” Wanqing Shao, a postdoc in the lab, is lead author on the paper. Ting Wang, PhD, Professor of...

Stormo Lab publishes paper in Communications Biology

The Stormo Lab published a paper in Communications Biology, “Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation.” The lab used the yeast GFP collection as a rapid screen for genes exhibiting feedback...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.” The preprint shares the lab’s work on the MYT1L gene and its...

Dougherty Lab contributes to paper in Cell Reports

The Dougherty Lab contributed to a paper by the Gabel Lab in Cell Reports, “DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.” Diana Christian and Dennis Wu, graduate...

Dougherty Lab publishes new review in Biological Psychiatry

The Dougherty Lab published a review in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.” Bernie Mulvey and Tomás Lagunas Jr., graduate students in the lab, are lead...

Wang Lab contributes to new paper in Nature

The Wang Lab contributed to a new paper in Nature, “A map of cis-regulatory elements and 3D genome structures in zebrafish.” Senior authors include Feng Yue, PhD, Director, Institute for Augmented Intelligence in Medicine – Center for Advanced...

Wang Lab contributes to new paper in Cell Reports

The Wang Lab contributed to a new paper in Cell Reports, “Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors.” Postdoc Hyung Joo Lee is an author, as well as staff scientist Xiaoyun Xing. Ting...

Morris Lab publishes new paper in eLife

The Morris Lab and the Solnica-Krezel Lab published a new paper in eLife, “High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures.” Kyaw Thu Minn, a graduate student in the Solnica-Krezel Lab,...

Morris Lab has new review published in Developmental Cell

The Morris Lab has a new review published in Developmental Cell, “Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development.” It discusses the history of these disciplines and how single-cell genomic technologies are enabling the...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Identification of compounds enhancing Aqp4 stop codon readthrough.” Darshan Sapkota, a postdoc in the lab, is lead author. Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University...

Lawson Lab publishes a paper in Physiological Reports

The Lawson Lab recently published a paper in Physiological Reports, “Spontaneous restoration of functional β‐cell mass in obese SM/J mice.” Alex Miranda, a graduate student in the lab, is lead author on the paper. Heather Lawson, PhD, Assistant Professor...

Milbrandt Lab publishes paper in eLife

The Milbrandt and DiAntonio Labs have a new paper in eLife, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...

Dr. Susan Dutcher publishes a new preview in Developmental Cell

Susan Dutcher, PhD, Professor of Genetics, Cell Biology and Physiology at Washington University School of Medicine, has published a new preview in Developmental Cell, “Basal Feet: Walking to the Discovery of a Novel Hybrid Cilium.” Dr. Dutcher co-authored...

Dr. Samantha Morris named 2020 NYSCF – Robertson Investigator

Samantha Morris, PhD, Assistant Professor of Genetics and Developmental Biology at Washington University School of Medicine in St. Louis, was recently named a 2020 NYSCF-Roberston Investigator. The NYSCF Investigator Program encourages promising early career...

Jin Lab publishes new paper in Nature Medicine

The Jin Lab recently had a paper published in Nature Medicine, “Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.” Sheng Chih (Peter) Jin, PhD, Assistant Professor in the Department of...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor of...

Biotech from Jeff Milbrandt and team acquired by Eli Lilly

Eli Lilly & Company recently acquired Disarm Therapeutics, a pre-clinical NAD-boosting company treating neuropathy and neurodegenerative diseases, for $135 million and a potential additional $1.2 billion in milestones. Disarm was founded by Atlas Venture; Jeff...

Lawson Lab publishes paper in Cell Reports

The Lawson Lab published a paper recently in Cell Reports, “Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice.” Caryn Carson, a graduate student in the lab who recently earned her PhD, is lead author on the paper. Heather...

Dougherty Lab has new preprint

The Dougherty Lab has a new preprint, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, a collaborating researcher in the lab and a a neonatologist at...

Wang Lang publishes paper in Genome Biology

The Wang Lab published a paper recently in Genome Biology, “Tissue-specific usage of transposable element-derived promoters in mouse development.” Benpeng Miao, a postdoc in the Wang Lab, is lead author on the paper. Ting Wang, PhD, Professor of Genetics...

Jin Lab has paper published in Nature Genetics

The Jin Lab recently had a paper published in Nature Genetics, “Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.” Sheng Chih (Peter) Jin, PhD, assistant professor of genetics at Washington University School of Medicine, is lead...

Mitra Lab has paper accepted in Bioinformatics

The Mitra Lab recently had a paper accepted in Bioinformatics, “The qBED track: a novel genome browser visualization for point processes.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author. The Wang Lab contributed to the paper. Ting...

Heather Lawson, Mike Provence, and Thomas Baranski get NIH R01 award

Heather Lawson, PhD, Assistant Professor in the Department of Genetics at Washington University School of Medicine, and Mike Provence, PhD, Professor of Genetics and Director of the Division of Statistical Genetics (DSG) at Washington University School of Medicine,...

Jin Lab publishes a paper in iScience

The Jin Lab published a paper in iScience, “Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia.” Sheng Chih (Peter) Jin, PhD, Assistant Professor in the Department of Genetics at Washington University...

Turner Lab has new preprint

The Turner Lab has a new preprint, “De Novo Mutation in an Enhancer of EBF3 in simplex autism.” Evin Padhi, a graduate student in the lab, is first author on the preprint. Tychele Turner, PhD, Assistant Professor in the Department of Genetics at Washington...

Mitra Lab has paper accepted in Genome Research

The Mitra Lab recently had a paper accepted in Genome Research, “High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.” Matt Lalli, a postdoc in...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo.” The work was done in collaboration with the Lawson Lab. Yating Liu, a...

Wang Lab publishes new paper in Science Advances

The Wang Lab recently published a new paper in Science Advances, “Cellular diversity of the regenerating caudal fin.” Yiran Hou, a graduate student in the lab, is first author on the paper. Ting Wang, Professor of Genetics, Professor of Computer Science...

Wang Lab has new preprint on transposable elements

The Wang Lab has a new preprint, “Transcript assembly improves expression quantification of transposable elements in single cell RNA-seq data.” Wanqing Shao, a postdoc in the lab, is first author on the preprint. Ting Wang, PhD, Professor of Genetics,...