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Postdoctoral positions to develop methods to drive differentiation of fibroblasts and iPSCs into glial and neuronal subtypes using Cas9/CRISPR technology.

The laboratories of Jeff Milbrandt and Rob Mitra invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will explore the use and optimization of Cas9 proteins as RNA-guided, artificial transcription factors (ATFs). Cas9-based ATFs will then be used to drive differentiation of fibroblasts and/or modified iPSCs into glial and neuronal subtypes. These cells, either harboring disease-associated variants or wildtype, will be used in targeted drug and genetic screens to identify and modulate pathways that are central to pathophysiology of neurodegenerative disease phenotypes. This project is funded by a grant from the NIH.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

 

The ideal applicants will have:

  1. PhD or MD/PhD in biological sciences or related fields

  2. Experience in molecular biology or genomics.

  3. Candidates with programming skills will be given priority (Python and R are preferred)

  4. Good spoken and written communication skills

  5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

 

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at cas9project@genetics.wustl.edu.

 


Postdoctoral positions to study the role of glial/axonal metabolic interactions in neurodegenerative disorders.

We invite mature, highly motivated candidates to apply for positions as postdoctoral fellows in our laboratory in the Department of Genetics at Washington University in St. Louis. These fellows will explore the role of axonal/glial interactions, particularly metabolic support, in neurodegenerative disorders. This work seeks to understand the role of NAD-regulated processes as well as other metabolic pathways in axon stability. Much of our focus is aimed at understanding the regulation of Sarm1 and its downstream signaling pathways that control axon maintenance. The role of glia in supporting axon health will also be explored; in particular, we are interested in the effects of abnormal glial metabolism on the loss of axon stability and function that are associated with peripheral neuropathy. These projects are funded by grants from the NIH.

Full-time positions are available immediately and are funded for three years, with the possibility of extension.

 

The ideal applicants will have:

  1. PhD or MD/PhD in biological sciences or related fields

  2. Experience in molecular biology, neuroscience or genomics.

  3. Good spoken and written communication skills

  4. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

 

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at axonal@genetics.wustl.edu.

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Postdoctoral positions to understand the molecular basis of transcription factor cooperativity and function.

The laboratory of Rob Mitra invites mature, highly motivated candidates to apply for positions as postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will seek to understand how different members of the basic helix-loop-helix transcription factor family achieve their specificities. Our research to date suggests that complex cooperative interactions with other transcription factors play a major role in determining this specificity, and fellows will seek to characterize these interactions and understand the fundamental principles that underlie this phenomenon. Experiments will be performed in mammalian and yeast cells.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

 

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields.
2. Experience in molecular biology, genomics, or yeast genetics.
3. Candidates with programming skills will be given priority (Python and R are preferred).
4. Good spoken and written communication skills.
5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

 

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Rob Mitra at rmitra@wustl.edu.

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Postdoctoral positions to develop an inducible molecular memory system to record transient states of CNS cells.

The laboratories of Rob Mitra and Joe Dougherty invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will develop and apply methods based on the novel ‘Calling Cards’ technology that is able to record the genome-wide interactions of any DNA-binding protein (e.g. a specific transcription factor, or a general transcriptional mediator), creating a permanent molecular memory of all binding events that occur at a given moment or epoch. This technology allows transient molecular interactions to be captured non-destructively, during a controlled window in time, and then read out at a later point in time. This methodology has been developed in vitro, and successful applicants will adapt the technology for use in the brain to provide the community with a versatile toolbox that can be applied to a number of outstanding problems.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

 

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields.
2. Experience in molecular biology or genomics.
3. Candidates with programming skills will be given priority (Python and R are preferred).
4. Good spoken and written communication skills.
5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

 

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Rob Mitra and Joe Dougherty at rmitra@wustl.edu, jdougherty@genetics.wustl.edu.

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Postdoctoral positions to study the role of glia in neurodegenerative disease.

 

The Milbrandt laboratory invites mature, highly motivated candidates to apply for positions as postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will explore the role of glia in maintaining axon and synapse integrity. We are interested in how Schwann cells provide metabolic support to the axon; particularly with regard to the non-myelinating and terminal Schwann cells. Mice with mutations that perturb glial metabolism, high-throughput neuron-Schwann cell co-cultures, and Cas9 screening techniques will be used to study axon dynamics in response to disruption of glial metabolism, such as occurs in diabetic peripheral neuropathy, Alzheimer’s disease and other neurodegenerative disorders. This project is funded by a grant from the NIH.

 

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

 

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology, genomics or neuroscience
3. Good spoken and written communication skills
4. The applicant must be able to visit St Louis for potential interviews without visa application

 

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience.

 

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at jmilbrandt@wustl.edu.