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Guoyan Zhao, PhD
Department of Neuroscience
Washington University School of Medicine
February 17, 2022 @ 12:00 pm - 1:00 pm
presents, “Striatal glia differentially contribute to Aβ pathology, tauopathy, and neurodegeneration”
Hosted by: Dr. Joe Dougherty
Seminar abstract: We performed the first single-nucleus transcriptome comparison of control, AD, and PD striata. We identified three astrocyte subpopulations and two microglia subpopulations conserved across different brain regions such as entorhinal cortex and prefrontal cortex, and between humans and mice. We reveal commonalities and differences between AD and PD glia and regional differences in their contributions toward amyloid pathology, tauopathy, and neurodegeneration.