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January 2022

Sarah Tishkoff, PhD

January 13, 2022 @ 12:00 pm - 1:00 pm

David and Lyn Silfen University Professor, Departments of Genetics and Biology, Perelman School of Medicine, School of Arts and Sciences, University of Pennsylvania.   Genomic Evolution and Adaptation in Africa: Implications for Health and Disease.

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Jason L. Stein, PhD
Assistant Professor
Department of Genetics & Neuroscience Center
University of North Carolina-Chapel Hill

January 20, 2022 @ 12:00 pm - 1:00 pm

presents, “Genetic influences on human cortical development and structure” Hosted by: Dr. Joseph Dougherty

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Bohdan (Bo) Khomtchouk, PhD
Department of Medicine
Section of Computational Biomedicine and Biomedical Data Science
Institute for Genomics and Systems Biology
University of Chicago

January 27, 2022 @ 12:00 pm - 1:00 pm

presents, "Cardioinformatics approaches for drug discovery"

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February 2022

Ye Zhang, PhD
Assistant Professor
Intellectual and Developmental Disabilities Research Center
Semel Institute for Neuroscience and Human Behavior
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine
University of California Los Angeles

February 3, 2022 @ 12:00 pm - 1:00 pm

presents, "Astrocyte and oligodendrocyte biology in development and disease: lessons from humans and mice" Hosted by: Dr. Tristan Li

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Postponed, new date TBD – Jennifer Wang, MD

February 10, 2022 @ 12:00 pm - 1:00 pm
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Guoyan Zhao, PhD
Assistant Professor
Department of Neuroscience
Washington University School of Medicine

February 17, 2022 @ 12:00 pm - 1:00 pm

presents, "Striatal glia differentially contribute to Aβ pathology, tauopathy, and neurodegeneration" Hosted by: Dr. Joe Dougherty Seminar abstract:  We performed the first single-nucleus transcriptome comparison of control, AD, and PD striata. We identified three astrocyte subpopulations and two microglia subpopulations conserved across different brain regions such as entorhinal cortex and prefrontal cortex, and between humans and mice.  We reveal commonalities and differences between AD and PD glia and regional differences in their contributions toward amyloid pathology, tauopathy, and neurodegeneration.

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Hugo Bellen, DVM, PhD
Departments of Molecular & Human Genetics and Neuroscience
Baylor College of Medicine

February 24, 2022 @ 12:00 pm - 1:00 pm

presents, "Tackling human gene function in model organisms" Hosted by: Dr. Tim Schedl Seminar abstract:  It is estimated that there are more than 300 million patients worldwide with a rare genetic disease. Many of these patients remain undiagnosed for many years. By sequencing their genomes and those of their relatives, human geneticists can now discover genetic variations that are rare or ultra-rare. However, considering that there are many polymorphisms in the population, assessing which variant(s) is/are related to the observed…

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March 2022

Jacob Kitzman, PhD
Assistant Professor
Departments of Human Genetics and Computational Medicine & Bioinformatics
University of Michigan Medical School

March 3, 2022 @ 12:00 pm - 1:00 pm

presents, "Large-scale approaches to classify and understand genetic variants" hosted by: Dr. Barak Cohen

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Benjamin Garcia, PhD
Professor and Chair
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine

March 10, 2022 @ 12:00 pm - 1:00 pm

Hybrid:  Connor Auditorium (FLTC), Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300 presents, "Quantitative proteomics for understanding epigenetic cancer mechanisms" hosted by: Dr. Susan Dutcher Seminar abstract: Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing.  Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations.…

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Christa Lese Martin, PhD, FACMG, DABMGG
Professor and Chief Scientific Officer
Director, Autism & Developmental Medicine Institute

March 17, 2022 @ 12:00 pm - 1:00 pm

presents, "Exploring the Genetics of Neurodevelopmental Psychiatric Disorders in a Health Care System" Hosted by: Dr. Tychele Turner Seminar abstract: Autism, schizophrenia, and other clinically distinct neurodevelopmental psychiatric disorders (NPD) have shared genetic etiologies, including copy number variants (CNVs) and single gene disorders. To date, rare variants that cause NPD have primarily been investigated in clinically-ascertained cohorts, therefore population-based estimates of their prevalence and penetrance are lacking. In this presentation, the prevalence, penetrance, and personal utility of NPD CNVs and…

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Evgeny Kvon, PhD
Assistant Professor
Department of Developmental & Cell Biology
University of California, Irvine

March 24, 2022 @ 12:00 pm - 1:00 pm

presents, "Deciphering Enhancer Function In Vivo" Hosted by: Dr. Tychele Turner Seminar abstract:  Transcriptional enhancers are a predominant class of non-coding functional DNA elements that control when and where genes are expressed. We use innovative mouse genome engineering and genomics techniques to address two questions about enhancer biology: 1. How do mutations in enhancers lead to human congenital disorders? and 2. How do enhancers relay regulatory information to their target genes over long genomic distances?

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Michael Province, PhD
Professor of Genetics and Biostatistics
Director, Division of Statistical Genomics
Center for Genome Sciences and Systems Biology
Washington University School of Medicine

March 31, 2022 @ 12:00 pm - 1:00 pm

presents, "May you live a full life for 100 years, plus one more to repent!  The Long Life Family Study" Hybrid:  Connor Auditorium (FLTC) or via Zoom webinar: https://wustl-hipaa.zoom.us/j/94367220300 Hosted by: Dr. Joe Dougherty Seminar abstract: The Long Life Family Study is a multinational, multicenter, longitudinal, observational study of ~5,000 participants in ~500 pedigrees selected for high rates of extreme longevity.  Fewer than 1% of the Framingham Heart Study pedigrees would qualify for LLFS.  On average, this cohort shows remarkable…

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April 2022

Shannon Lauberth, PhD
Associate Professor
Department of Biochemistry and Molecular Genetics
Feinberg School of Medicine
Northwestern University

presents, "The role of noncoding RNAs in cancer: shedding light on the transcriptomic dark matter" Hosted by: Dr. Shamim Mollah HYBRID Zoom attendee webinar link:https://wustl-hipaa.zoom.us/j/94367220300 In-person:  Couch Building, 6001B Seminar abstract: Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing, and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). While eRNAs have become…

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Jeremy Reiter, MD, PhD
Professor and Chair
Department of Biochemistry and Biophysics
University of California, San Francisco

presents, "How cilia signal" Hybrid Zoom attendee webinar link:  https://wustl-hipaa.zoom.us/j/94367220300 In-person: Connor Auditorium, FLTC hosted by:  Drs. Susan Dutcher and Moe Mahjoub

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Jin Billy Li, PhD
Associate Professor
Department of Genetics
Stanford University

presents, “RNA Editing and Innate Immunity” Hosted by: Dr. Rob Mitra Hybrid Zoom attendee webinar link: https://wustl-hipaa.zoom.us/j/94367220300 In-person:  Couch 6001B Seminar abstract:  To avoid aberrant innate immunity, endogenous double-stranded RNA (dsRNA) must be edited by ADAR1, suppressing cytosolic MDA5-mediated dsRNA sensing. Mice without RNA editing by ADAR1 are embryonic lethal, but live to full life span upon MDA5 removal. In humans, ADAR1 loss-of-function and MDA5 gain-of-function mutations lead to rare autoimmune diseases. In this talk, I will discuss our recent…

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Andrew Yoo, PhD
Associate Professor
Department of Developmental Biology
Washington University School of Medicine

presents, "Modeling late-onset human neurodegeneration by neuronal reprogramming" Hosted by: Dr. Joseph Dougherty HYBRID In-person: Couch, 6001B Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300

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May 2022

23rd Annual Donald C. Shreffler Memorial Lecture
David Baker, PhD
Professor of Biochemistry & Head, Institute for Protein Design
Department of Biochemistry
University of Washington

Talk title: "Protein design using deep learning" Seminar abstract: Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address current-day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, we design new proteins from scratch to optimally solve the problem at hand.  We now use two approaches.  First,…

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POSTPONED to later date TBD
Panagiotis Roussos, MD, MS, PhD
Department of Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai

May 12, 2022 @ 12:00 pm - 1:00 pm

presents, "Title TBD" Hosted by:  Dr. Joe Dougherty

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Ami Bhatt, MD, PhD
Associate Professor
Departments of Medicine (Hematology) and Genetics
Stanford University

presents, "From precise microbial genomics to precision medicine" Talk abstract:  The Bhatt lab seeks to illuminate the interplay between the microbial environment and host/clinical factors in human diseases. In this talk, Dr. Bhatt will share exciting new developments on the application of novel molecular and computational tools to study strain level dynamics of the microbiome, understand how microbial genomes change over time and predict the functional output of microbiomes. She will also speak about recent efforts to understand how microbes “talk” to one another…

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