presents, "Single cell analysis of Gene-Environment interactions: not your average eQTL" Hosted by:  Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC) Talk abstract:  In the past ten years we have been studying genetic and environmental factors that contribute to asthma severity in children living in the metropolitan Detroit area. We have performed bulk and single cell RNA-sequency and uncovered psychosocial and genetic factors associated with gene regulation in children with asthma. I will present our findings on the dynamic genetic…

presents, "Expanding studies of global genomic diversity with complete, telomere-to-telomere (T2T) assembly of diploid genomes" Hosted by:  Dr. Ting Wang In-person only:  Connor Auditorium (FLTC) Talk abstract:  The Telomere-to-Telomere (T2T) Consortium has finished the first truly complete human genome, representing gapless assemblies for all 22 autosomes plus Chromosomes X and Y, corrects numerous errors, and introduces nearly 200 million bp of novel sequence. Here I will discuss new methods to automate T2T diploid chromosome assembly and quality assessment, and the…

presents, "Worms, bugs & drugs" Hosted by:  Dr. Tychele Turner FULLY VIRTUAL Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300

presents, "What Makes Us Human? Development and Evolution of Prefrontal Circuits Underlying Cognitive Control" Hosted by:  Dr. Peter Jin In-person only:  Connor Auditorium (FLTC) Talk abstract:  In my presentation, I will describe some of our recent efforts to better understand the molecular and cellular basis of how neural circuits form within the developing cerebral cortex, the outside part of the mammalian brain that processes our senses, commands motor activity, and helps us perform higher-order cognitive functions like language. I will…

presents, "Inherited chromatin states shape transcription patterns in offspring and grandoffspring" Talk abstract:  The role that chromatin states serve in transmitting gene expression information across generations via sperm and oocytes is not well understood. We utilized a model in which C. elegans sperm and oocyte alleles were inherited in different states of the repressive mark H3K27me3. This resulted in the alleles achieving different transcriptional states within the nuclei of offspring. Using this model, we showed that sperm alleles inherited without H3K27me3 were sensitive to up-regulation in offspring…

presents, "Epigenetic regulation of human cortical development and its disruption to cause neurodevelopmental disorders" Talk abstract: Work in my laboratory focuses on modeling gene regulatory networks that control various aspects of human brain development. We are interested in identifying novel transcriptional and epigenetic regulators of these networks, defining mechanisms by which they control brain development, and studying how pathogenic mutations in genes encoding these regulators contribute to neurodevelopmental disorders. Hosted by:  Dr. Tristan Li In-person only:  Connor Auditorium (FLTC)

presents, "Epigenetic regulation and environmental adaptation" Talk abstract:  The Zhong laboratory is interested in how cellular machines sense intrinsic and extrinsic cues and alter chromatin landscapes to generate adaptive responses. They focus on epigenetic regulation by exploring how chromatin dynamics is established, maintained, erased, and inherited over time, and how altered chromatin modifications lead to improved plant traits and environmental adaptation. They combine functional genomics and high-throughput proteomics and genomics techniques together with genetic and biochemical tools to understand the function…

presents, "Cellular reprogramming to study neuronal lineage specification and develop cell therapies for the brain" Talk title: I will talk about neuronal cell specification centered around transcription factor regulation and applications of microglia replacement therapies. Hosted by:  Dr. Joe Dougherty In-person only:  Connor Auditorium (FLTC)

presents, "Negative impacts of chromosome 21 gene dosage on primary cilia formation and signaling" Talk abstract:  Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Our work reveals that elevated Pericentrin from trisomy 21 disrupts multiple early steps of ciliogenesis and creates persistent trafficking defects in ciliated cells and in a mouse model of Down syndrome. Hosted by:  Dr. Susan Dutcher In-person only: …

presents, "Genetics in the Racial Imagination" Hosted by:  Dr. Brett Maricque In-person only:  Connor Auditorium (FLTC) Talk abstract: How does genetics figure in everyday Americans’ beliefs about racial difference? Drawing on interviews with college students, textbook lessons, and public controversies over racial identity, I trace the ways in which many Americans link race to biological variation. And I briefly take up the counterpoint question—how does race figure in genetics?—by concluding with a discussion of the National Academies of Sciences, Engineering,…

presents, "Role of African Ancestry in genomic and proteomic changes in breast cancer disparities" Hosted by:  Alla Karpova and Genetics trainees & postdocs In-person only:  Connor Auditorium (FLTC)

presents, "The RASopathies: Too much, too little and getting to just right" Talk abstract:  Noonan syndrome and the related disorders, now called the RASopathies, are phenotypically related traits arising from perturbations, largely engendering gain of function, in the RAS/mitogen-activated protein kinase signal transduction pathway. In this lecture, insights gained from phenotype-first and genotype-first studies of the RAsopathies will be provided as well as those from cell and animal model research, informing the development of mechanistic therapies for these genetic traits.…

presents, "Time is (not) on your side: mitotic control of G1 progression" Hosted by:  Dr. Susan Dutcher In-person only:  Connor Auditorium (FLTC)

presents, "Fitting the pieces together: how cells make centrosomes and cilia" Talk abstract: The Wang lab studies how the architecture of organelles is created, and how architecture relates to cellular function and physiology. We are particularly interested in centrosomes and cilia, conserved organelles involved in cell division, signaling, and motility. I will discuss our work on a unique architectural element of centrosomes, the triplet microtubules, as well as our work on centrosome and cilia architecture in olfactory sensory neurons. Hosted…

presents, "Transcript structure diversity and postnatal transcriptional regulation in ENCODE4" Hosted by:  Dr. Heather Lawson In-person only:  Connor Auditorium (FLTC)

presents, "Functional analysis of autism risk genes in zebrafish" Hosted by:  Dr. Joe Dougherty In-person only:  Connor Auditorium (FLTC)

presents, "Mapping the regulatory wiring of the genome to connect disease variants to functions" Talk abstract: I will present two new stories from the lab. First, I will describe unpublished work regardin how cohesin tunes 3D enhancer-promoter communication. Second, I will present work to map genes and pathways for coronary artery disease using large-scale Perturb-seq. Hosted by:  Dr. Heather Lawson In-person only:  Connor Auditorium (FLTC)

presents, "The sequence determinants of human transcriptional activators and repressors: high-throughput discovery and systematic perturbations" Hosted by:  Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC) Talk abstract:  Human transcription factors (TFs) contain binding domains that allow them to recognize specific DNA sequences and effector domains that interact with transcriptional machinery or other cofactors to activate or repress transcription. By performing high-throughput pooled measurements testing ~110,000 candidate sequences that are consecutive fragments from human transcription factors and chromatin regulators, we were able to…

presents, "Genomics of developmental brain anomalies" Hosted by:  Dr. Peter Jin In-person only:  Connor Auditorium (FLTC)

presents, "Integrative Proximity Proteomics Reveals Mechanisms and Therapeutic Opportunities for the KEAP1/NRF2 Signaling Pathway" Hosted by:  Dr. Tychele Turner In-person only:  Connor Auditorium (FLTC)