Our Mission

MillerLab_Washington_University_Gel1_smallThe Genome Engineering Center (GEC) at Washington University uses engineered endonucleases to create targeted modifications of mammalian genomes in order to speed scientific discovery, validate therapeutic targets, and increase scientific productivity.

Through our cell engineering services, we work with investigators to create custom, user-defined cell lines.  The GEC can generate modified cells with single base pair point mutations, small insertions or deletions, large insertions or deletions, gene knockout, and even multiplex modifications.

We have experience using zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPRs) to create modified cells.  The GEC creates novel, modified cell lines with the ultimate goal of advancing scientific discovery as a means to combat disease.