Our laboratory is interested in the neurogenetics and genomics of behavior in health and disease. We utilize a variety of techniques spanning from human molecular genetics and informatics to mouse behavioral neuroscience and neuroanatomy. We also continue both to develop novel methods for transgenesis, gene manipulation, and transcriptional profiling of the brain. We use these tools to develop mouse models, particularly those that mimic genetic variations identified from human patient populations, with the goal of trying to understand the cellular and molecular underpinnings of behavior. We are particularly focused on the neurodevelopmental disorder of autism. Based on human genetics and cell specific expression profiling we have successfully identified genes regulating behaviors ranging from social communication to sleep homeostasis. We are now expanding these efforts to try and uncover the neurobiology mediating the effects of these genes.