Publications

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Last manual update (09/09/17) of work published since starting at Wash U:

  1. Abernathy D.G., Kim, W.K, McCoy, M.J, Lake, A.M., Ouwenga, R., Lee, S.W., Xing, X., Li, D., Lee, H.J., Heuckeroth, R.O., Dougherty, J.D., Wang, T., Yoo, A.S. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell: Stem Cell (2017). doi: 10.1016/j.stem.2017.08.002
  2. Thompson, S.E., Lake, A.M., Kenny, P., Saunders, M., Sakers, K., Iyer, N., Dougherty, J.D., Sakiyama-Elbert, S.E. Different Mixed Astrocyte Populations Derived from Embryonic Stem Cells have Variable Neuronal Growth Support Capacities. Stem Cells Dev (2017). doi: 10.1089/scd.2017.0121
  3. Maloney, S.E., Chandler, K.C., Anastasaki, C., Rieger, M.A., Gutmann, D.H., Dougherty, J.D. Characterization of early communicative behavior in mouse models of neurofibromatosis type 1. Autism Research (2017). doi: 10.1002/aur.1853
  4. Ouwenga, R., Lake, A.M., O’Brien, D., Mogha, A., Dani, A., Dougherty, J.D. Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In VivoJournal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.3044-16.2017
  5. Dougherty, J.D. Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons. Scientific Reports (2017). doi: 10.1038/s41598-017-08618-2
  6. Chen, W.V., Nwakeze, C.L., Denny, C.A., O’Keeffe, S., Rieger, M.A., Mountoufaris, G., Kimer, A., Dougherty, J.D., Hen, R., Wu, Q., Maniatis, T. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (2017). doi: 10.1126/science.aal3231
  7. Sakers, K., Lake, A.M., Khazanchi, R., Ouwenga, R., Vasek, M.J., Dani, A., Dougherty, J.D. Astrocytes locally translate transcripts in their peripheral processes. Proceedings of the National Academy of Sciences (2017). doi: 10.1073/pnas.1617782114
  8. Hoye, M.L, Koval E.D., Wegener, A.J., Hyman, T.S., Yang, C., O’Brien, D.R., Miller R.L., Cole, T., Schoch, K.M., Shen, T., Kunikata, T., Richard, J.P., Gutmann D.H., Maragakis N.J., Kordasiewicz, H.B., Dougherty, J.D., Miller, T.M. microRNA profiling reveals marker of motor neuron disease in ALS modelsJournal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.3582-16.2017
  9. Dalal, J.S., Yang, C. Sapkota, D., Lake, A.M., O’Brien, D.R., Dougherty, J.D. Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural CellsFrontiers in Molecular Neuroscience (2017). doi: 10.3389/fnmol.2017.00009
  10. Maricque, B. B, Dougherty, J. D., Cohen, B. A. A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells. Nucleic Acids Research (2016). doi links to a dysfunctional NAR page at this time; however, an open-access copy is available through Washington University here.
  11. Deming, Y., Black, K., Carrell, D., Cai, Y., Del-Aguila, J. L., Fernandez M. V., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Huang, K. L., Sutphen, C. L., Tarawneh, R., Fagan, A. M., Holtzman, D. M., Morris, J. C., Goate, A. M., Dougherty, J. D., Cruchaga, C. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. BMC Neurology (2017). doi:10.1186/s12883-016-0742-9
  12. Rieger, M. A. and Dougherty, J. D. Analysis of within Subjects Variability in Mouse Ultrasonic Vocalization: Pups Exhibit Inconsistent, State-Like Patterns of Call Production. Frontiers in Behavioral Neuroscience (2016). doi:10.3389/fnbeh.2016.00182
  13. O’Connor, S. D., Cabrera, O. H., Dougherty, J. D., Singh, S., Swiney, B. S.,Salinas-Contreras, P., Farber, N. B., and Noguchi, K. K. Dexmedetominidine Protects Against Glucocorticoid Induced Progenitor Cell Apoptosis in Neonatal Mouse Cerebellum. The Journal of Maternal-Fetal & Neonatal Medicine (2016). doi:10.1080/14767058.2016.1241763
  14. Reddy, A. S., O’Brien, D., Pisat, N., Weichselbaum, C. T., Sakers, K., Lisci, M., Dalal, J. S., and Dougherty, J. D. A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain. Biological Psychiatry (2016). doi:10.1016/j.biopsych.2016.02.021
  15. Usui, N., Co, M., Harper, M., Rieger, M. A., Dougherty, J. D., and Konopka, G. Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development. BPS (2016). doi:10.1016/j.biopsych.2016.02.008
  16. Wells, A., Kopp, N., Xu, X., O’Brien, D. R., Yang, W., Nehorai, A., Adair-Kirk, T. L., Kopan, R., and Dougherty, J. D. The Anatomical Distribution of Genetic Associations. Nucleic Acids Research 43, no. 22 (2015): 10804–10820. doi:10.1093/nar/gkv1262
  17. Kopp, N., Climer, S., and Dougherty, J. D. Moving From Capstones Toward Cornerstones: Successes and Challenges in Applying Systems Biology to Identify Mechanisms of Autism Spectrum Disorders. Frontiers in Genetics 6, (2015): 301. doi:10.3389/fgene.2015.00301
  18. Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H.-C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R., and Konopka, G. FoxP1 Orchestration of ASD-Relevant Signaling Pathways in the Striatum. Genes & Development 29, no. 20 (2015): 2081–2096. doi:10.1101/gad.267989.115
  19. Gockley, J., Willsey, A. J., Dong, S., Dougherty, J. D., Constantino, J. N., and Sanders, S. J. The Female Protective Effect in Autism Spectrum Disorder Is Not Mediated by a Single Genetic Locus. Molecular Autism 6, (2015): 25.
  20. Maloney, S. E., Khangura, E., and Dougherty, J. D. The RNA-Binding Protein Celf6 Is Highly Expressed in Diencephalic Nuclei and Neuromodulatory Cell Populations of the Mouse Brain. Brain Structure and Function (2015). doi:10.1007/s00429-015-1005-z
  21. Tupal, S., Rieger, M.A., Ling, G, Park, T.J., Dougherty, J.D., Goodchild, A.K., & Gray, P.A. Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors. Eur. J. Neurosci 40(7), (2015). doi:10.1111/ejn.12669
  22. Yuan, H. & Dougherty, J. D. Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association. Autism Res, 7:2, (2014). PMID: 24574247
  23. Xu, X., Wells, A. B., O’Brien, D. R., Nehorai, A. & Dougherty, J. D. Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders. J Neurosci 34, 1420-1431, (2014). PMID: 24453331
  24. Gorlich, A., Antolin-Fontes, B., Ables, J. L., Frahm, S., Slimak, M. A., Dougherty, J. D. & Ibanez-Tallon, I. Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. Proc Natl Acad Sci U S A 110, 17077-17082, (2013). PMID: 24082085
  25. Foo, L. C. & Dougherty, J. D. Aldh1L1 is expressed by postnatal neural stem cells in vivo. Glia 61, 1533-1541, (2013). PMID: 23836537
  26. Dalal J., Roh J.H., Maloney S.E., Akuffo A., Shah S., Yuan H., Wamsley B., Jones W.B., Strong C.D., Gray P.A., Holtzman D.M., Heintz N., Dougherty J.D.  (2013) Genes &  Development Dalal 2013
  27. Dougherty J.D., Maloney SE, Wozniak DF, Rieger MA, Sonnenblick L, Coppola G, Mahieu NG, Zhang J, Cai J, Patti GJ, Abrahams BS, Geschwind DH, Heintz N (2013) The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. Journal of Neuroscience. Feb 13;33(7):2732-2753 Dougherty 2013
  28. Tryon R.C., Pisat N., Johnson S.L., Dougherty J.D. (2013) Development of translating ribosome affinity purification for zebrafish. GenesisTyron
  29. Dougherty, J.D., Fomchenko, E.I., Afua A. Akuffo, Schmidt, E., Helmy, K.Y., Bazzoli, E., Brennan, C.W., Holland, E.C., and Milosevic, A. (2012). Candidate pathways for promoting differentiation and quiescence in of oligodendrocyte progenitor-like cells in glioblastoma. Cancer Research, Sep 15;72(18):4856-68.Dougherty 2012 Cancer Res
  30. Dougherty, J.D., Zhang, J., Feng, H., Gong, S., and Heintz, N. (2012). Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. PLoS One 7, e40511.Dougherty 2012 Plos One
  31. Tien, A.C., Tsai, H.H., Molofsky, A.V., McMahon, M., Foo, L.C., Kaul, A., Dougherty, J.D., Heintz, N., Gutmann, D.H., Barres, B.A., Rowitch, D.A.. (2012). Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development 139, 2477-2487.
  32. Fomchenko, E.I., Dougherty, J.D., Helmy, K.Y., Katz, A.M., Pietras, A., Brennan, C. Husel, J.T., Milosevic, A., and Holland, E.C. (2011).  Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionPlos One, 6(7): e20605

Joe’s work pre-dating the lab:

  1. Dougherty, J. D., Schmidt, E.F., Nakajima, M., and Heintz, N. (2010). Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38, 4218-4320.
  2. Doyle J. P.*, Dougherty J.D*, Heiman M., Schmidt E. F., Stevens T. R., Ma G., Bupp S., Shrestha P., Shah R. D., Doughty M. L., Gong S., Greengard P., Heintz N. (2008) Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 135, 749-62.
  3. Nakano, I.*, Dougherty, J.D.*, Kim, K., Klement, I., Geschwind, D. H., and Kornblum, H. I. (2007). Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells 25, 1975-1984.
  4. Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., and Wu, H. (2006). PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A 103, 111-116.
  5. Dougherty, J. D., Garcia, A. D., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E. M., Sofroniew, M. V., Kornblum, H. I., and Geschwind, D. H. (2005). PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci 25, 10773-10785.
  6. Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., and Black, D. L. (2005). Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol 25, 10005-10016.
  7. Nakano, I., Paucar, A. A., Bajpai, R., Dougherty, J. D., Zewail, A., Kelly, T. K., Kim, K. J., Ou, J., Groszer, M., Imura, T., et al. (2005). Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol 170, 413-427.
  8. Fox, I. J., Paucar, A. A., Nakano, I., Mottahedeh, J., Dougherty, J. D. & Kornblum, H. I. Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones–implications for stem cell biology. Brain research. Developmental brain research 153, 121-125, (2004).
  9. Easterday MC, Dougherty J.D., Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI (2003) Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol 264:309-322.
  10. Geschwind, D. H., Ou, J., Easterday, M. C., Dougherty, J. D, Jackson, R. L., Chen, Z., Antoine, H., Terskikh, A., Weissman, I. L., Nelson, S. F., and Kornblum, H. I. (2001). A genetic analysis of neural progenitor differentiation. Neuron 29, 325-339.