Publications

Links to search engines:

Google Scholar
Pubmed

Last manual update (10/29/18) of work published since starting at Wash U:

  1. Medvedeva, V.P., Rieger, M.A., Vieth, B., Mombereau, C., Ziegenhain, C., Ghosh, T., Cressant, A., Enard, W., Granon, S., Dougherty, J.D., and Groszer, M. Altered social behavior in mice carrying a cortical Foxp2 deletion.  Human Molecular Genetics (2018). doi: 10.1093/hmg/ddy372
  2. Maloney, S.E., Akula, S., Rieger, M.A., McCullough, K.B., Chandler, K., Corbett A.M., McGowin, A.E., and Dougherty, J.D.  Examining the Reversability of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure. eNeuro (2018). doi: 10.1523/ENEURO.0120-18.2018
  3. Kopp, N.D., Parrish, P.C.R., Lugo, M., Dougherty, J.D., and Kozel, B.A. Exome sequencing of 85 Williams-Beuren syndrome cases rules out coding variation as a major contributor to remaining variance in social behavior. Molecular Genetics & Genomic Medicine (2018). doi: 10.1002/mgg3.429
  4. Hoye, M.L., Regan, M.R., Jensen, L.A., Lake A.M., Reddy, L.V., Vidensky, S., Richard, J.P., Maragakis, N.J., Rothstein, J.D., Dougherty, J.D., and Miller, T.M. Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. Brain (2018). doi: 10.1093/brain/awy182.
  5. Li, Z., Del-Aguila, J.L., Dube, U., Budde, J., Martinez, R., Black, K., Xiao, Q., Cairns, N.J.; Dominantly Inherited Alzheimer Network (DIAN), Dougherty, J.D., Lee, J.M., Morris, J.C., Bateman, R.J., Karch, C.M., Cruchaga, C., and Harari, O. Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure. Genome Medicine (2018). doi: 10.1186/s13703-018-0551-4
  6. Sapkota, D., Lake, A.M., Yang, W., Yang, C., Wesseling, H., Guise, A., Uncu, C,. Dalal, J.S., Kraft, A., Lee, J-M., Sands, M.S., Steen, J.A., and Dougherty, J.D. Cell type specific profiling of alternative translation identifies novel protein isoforms in the mouse brain. Biorxiv (2018). doi: 10.1101/324236
  7. Mulvey, B., Bhatti, D.L., Gyawali, S., Lake, A.M., Kriaucionis, S., Ford, C.P., Bruchas, M.R., Heintz, N., and Dougherty, J.D. Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus. Cell Reports (2018). doi: 10.1016/j.celrep.2018.04.054
  8. Avetisyan, M., Rood, J.E., Huerta Lopez, S., Sengupta, R., Wright-Jin, E., Dougherty, J.D., Behrens, E.M., and Heuckeroth, R.O. Muscularis macrophage development in the absence of an enteric nervous system. PNAS (2018). doi: 10.1073/pnas.1802490115
  9. Maloney, S.E., Creeley, C., Hartman, R.E., Yuede, C.M., Zorumski, C.F., Jevtovic-Todorovic, V., Dikranian, K., Noguchi, K.K., and Farber, N.B. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment. Neurobiology of Learning and Memory (2018). doi: 10.1016/j.nlm.2018.03.014
  10. Mulvey, B. and Dougherty, J.D. Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes. Cell (2018). doi: 10.1016/j.cell.2017.12.037
  11. Barnes, T.D., Rieger, M.A., Dougherty, J.D., and Holy, T.E. Group and Individual Variability in Mouse Pup Isolation Calls Recorded on the Same Day Show Stability. Frontiers in Behavioral Neuroscience (2017). doi: 10.3389/fnbeh.2017.00243
  12. Dougherty, J.D. The Expanding Toolkit of Translating Ribosome Affinity Purification. Journal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.1929-17.2017
  13. Dougherty, J.D., Yang, C., and Lake, A.M. Systems in the Central Nervous System: A Brief Perspective on Essential Recent Advancements. Current Opinions in Systems Biology (2017). doi: 10.1016/j.coisb.2017.04.011
  14. Abernathy D.G., Kim, W.K, McCoy, M.J, Lake, A.M., Ouwenga, R., Lee, S.W., Xing, X., Li, D., Lee, H.J., Heuckeroth, R.O., Dougherty, J.D., Wang, T., and Yoo, A.S. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell: Stem Cell (2017). doi: 10.1016/j.stem.2017.08.002
  15. Thompson, S.E., Lake, A.M., Kenny, P., Saunders, M., Sakers, K., Iyer, N., Dougherty, J.D., and Sakiyama-Elbert, S.E. Different Mixed Astrocyte Populations Derived from Embryonic Stem Cells have Variable Neuronal Growth Support Capacities. Stem Cells and Development (2017). doi: 10.1089/scd.2017.0121
  16. Maloney, S.E., Chandler, K.C., Anastasaki, C., Rieger, M.A., Gutmann, D.H., and Dougherty, J.D. Characterization of early communicative behavior in mouse models of neurofibromatosis type 1. Autism Research (2017). doi: 10.1002/aur.1853
  17. Ouwenga, R., Lake, A.M., O’Brien, D., Mogha, A., Dani, A., and Dougherty, J.D. Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In VivoJournal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.3044-16.2017
  18. Dougherty, J.D. Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons. Scientific Reports (2017)doi: 10.1038/s41598-017-08618-2
  19. Chen, W.V., Nwakeze, C.L., Denny, C.A., O’Keeffe, S., Rieger, M.A., Mountoufaris, G., Kimer, A., Dougherty, J.D., Hen, R., Wu, Q., and Maniatis, T. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (2017). doi: 10.1126/science.aal3231
  20. Sakers, K., Lake, A.M., Khazanchi, R., Ouwenga, R., Vasek, M.J., Dani, A., and Dougherty, J.D. Astrocytes locally translate transcripts in their peripheral processes. Proceedings of the National Academy of Sciences (2017). doi: 10.1073/pnas.1617782114
  21. Hoye, M.L, Koval E.D., Wegener, A.J., Hyman, T.S., Yang, C., O’Brien, D.R., Miller R.L., Cole, T., Schoch, K.M., Shen, T., Kunikata, T., Richard, J.P., Gutmann D.H., Maragakis N.J., Kordasiewicz, H.B., Dougherty, J.D., and Miller, T.M. microRNA profiling reveals marker of motor neuron disease in ALS modelsJournal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.3582-16.2017
  22. Dalal, J.S., Yang, C. Sapkota, D., Lake, A.M., O’Brien, D.R., and Dougherty, J.D. Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural CellsFrontiers in Molecular Neuroscience (2017). doi: 10.3389/fnmol.2017.00009
  23. Maricque, B.B, Dougherty, J.D., and Cohen, B.A. A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells. Nucleic Acids Research (2016). doi: 10.1093/nar/gkw942
  24. Deming, Y., Black, K., Carrell, D., Cai, Y., Del-Aguila, J.L., Fernandez M.V., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Huang, K.L., Sutphen, C.L., Tarawneh, R., Fagan, A.M., Holtzman, D.M., Morris, J.C., Goate, A.M., Dougherty, J.D., and Cruchaga, C. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. BMC Neurology (2017). doi:10.1186/s12883-016-0742-9
  25. Rieger, M.A. and Dougherty, J.D. Analysis of within Subjects Variability in Mouse Ultrasonic Vocalization: Pups Exhibit Inconsistent, State-Like Patterns of Call Production. Frontiers in Behavioral Neuroscience (2016). doi:10.3389/fnbeh.2016.00182
  26. O’Connor, S.D., Cabrera, O.H., Dougherty, J.D., Singh, S., Swiney, B.S.,Salinas-Contreras, P., Farber, N.B., and Noguchi, K.K. Dexmedetominidine Protects Against Glucocorticoid Induced Progenitor Cell Apoptosis in Neonatal Mouse Cerebellum. The Journal of Maternal-Fetal & Neonatal Medicine (2016). doi:10.1080/14767058.2016.1241763
  27. Reddy, A.S., O’Brien, D., Pisat, N., Weichselbaum, C.T., Sakers, K., Lisci, M., Dalal, J.S., and Dougherty, J.D. A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain. Biological Psychiatry (2016). doi:10.1016/j.biopsych.2016.02.021
  28. Usui, N., Co, M., Harper, M., Rieger, M.A., Dougherty, J. D., and Konopka, G. Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development. Biological Psychiatry (2016). doi:10.1016/j.biopsych.2016.02.008
  29. Wells, A., Kopp, N., Xu, X., O’Brien, D.R., Yang, W., Nehorai, A., Adair-Kirk, T.L., Kopan, R., and Dougherty, J.D. The Anatomical Distribution of Genetic Associations. Nucleic Acids Research (2015). doi:10.1093/nar/gkv1262
  30. Kopp, N., Climer, S., and Dougherty, J.D. Moving From Capstones Toward Cornerstones: Successes and Challenges in Applying Systems Biology to Identify Mechanisms of Autism Spectrum Disorders. Frontiers in Genetics (2015). doi:10.3389/fgene.2015.00301
  31. Araujo, D.J., Anderson, A.G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M.A., Huang, H.-C., Rajkovich, K., Loerwald, K.W., Dekker, J.D., Tucker, H.O., Dougherty, J.D., Gibson, J.R., and Konopka, G. FoxP1 Orchestration of ASD-Relevant Signaling Pathways in the Striatum. Genes & Development (2015). doi:10.1101/gad.267989.115
  32. Gockley, J., Willsey, A.J., Dong, S., Dougherty, J.D., Constantino, J.N., and Sanders, S.J. The Female Protective Effect in Autism Spectrum Disorder Is Not Mediated by a Single Genetic Locus. Molecular Autism (2015). doi: 10.1186/s13229-015-0014-3
  33. Maloney, S.E., Khangura, E., and Dougherty, J.D. The RNA-Binding Protein Celf6 Is Highly Expressed in Diencephalic Nuclei and Neuromodulatory Cell Populations of the Mouse Brain. Brain Structure and Function (2015). doi:10.1007/s00429-015-1005-z
  34. Tupal, S., Rieger, M.A., Ling, G, Park, T.J., Dougherty, J.D., Goodchild, A.K., and Gray, P.A. Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors. European Journal of Neuroscience (2015). doi:10.1111/ejn.12669
  35. Yuan, H. and Dougherty, J.D. Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association. Autism Research (2014). doi: 10.1002/aur.1363
  36. Xu, X., Wells, A.B., O’Brien, D.R., Nehorai, A. and Dougherty, J.D. Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders. Journal of Neuroscience (2014). 10.1523/JNEUROSCI.4488-13.2014
  37. Maloney, S.E., Rieger, M.A., Dougherty, J.D. Identifying essential cell types and circuits in AutismInternational Review of Neurobiology (2013). doi: 10.1016/B978-0-12-418700-9.00003-4
  38. Gorlich, A., Antolin-Fontes, B., Ables, J.L., Frahm, S., Slimak, M.A., Dougherty, J.D., and Ibanez-Tallon, I. Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. Proceedings of the National Academy of Sciences (2013). doi: 10.1073/pnas.1313103110
  39. Foo, L.C. and Dougherty, J.D. Aldh1L1 is expressed by postnatal neural stem cells in vivo. Glia (2013). doi: 10.1002/glia.22539
  40. Dalal J., Roh J.H., Maloney S.E., Akuffo A., Shah S., Yuan H., Wamsley B., Jones W.B., Strong C.D., Gray P.A., Holtzman D.M., Heintz N., and Dougherty J.D. Translational Profiling of Hypocretin Neurons Identifies Candidate Molecules for Sleep Regulation. Genes & Development (2013). doi: 10.1101/gad.207654.112
  41. Dougherty J.D., Maloney S.E., Wozniak D.F., Rieger M.A., Sonnenblick, L., Coppola, G., Mahieu, N.G., Zhang, J., Cai, J., Patti, G.J., Abrahams, B.S., Geschwind, D.H., and Heintz, N. The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. Journal of Neuroscience (2013). doi: 10.1523/JNEUROSCI.4762-12.2013
  42. Tryon, R.C., Pisat, N., Johnson, S.L., and Dougherty J.D. Development of translating ribosome affinity purification for zebrafish. Genesis (2013). doi: 10.1002/dvg.22363
  43. Dougherty, J.D., Fomchenko, E.I., Afua A. Akuffo, Schmidt, E., Helmy, K.Y., Bazzoli, E., Brennan, C.W., Holland, E.C., and Milosevic, A. Candidate pathways for promoting differentiation and quiescence in of oligodendrocyte progenitor-like cells in glioblastoma. Cancer Research (2012). doi: 10.1158/0008-5472.CAN-11-2632
  44. Dougherty, J.D. Cellomics: Characterization of neural subtypes by high-throughput methods and transgenic mouse models. In: Coppola G (Ed). OMICs in Neuroscience (2013)Oxford University Press.
  45. Dougherty, J.D., Zhang, J., Feng, H., Gong, S., and Heintz, N. (2012). Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. PLoS One (2012). doi: 10.1371/journal.pone.0040511
  46. Tien, A.C., Tsai, H.H., Molofsky, A.V., McMahon, M., Foo, L.C., Kaul, A., Dougherty, J.D., Heintz, N., Gutmann, D.H., Barres, B.A., and Rowitch, D.A.. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (2012). doi: 10.1242/dev.077214
  47. Fomchenko, E.I., Dougherty, J.D., Helmy, K.Y., Katz, A.M., Pietras, A., Brennan, C. Husel, J.T., Milosevic, A., and Holland, E.C. Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionPLoS One (2011). doi: 10.1371/journal.pone.0020605

Joe’s work pre-dating the lab:

  1. Dougherty, J. D., Schmidt, E.F., Nakajima, M., and Heintz, N. (2010). Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38, 4218-4320.
  2. Doyle J. P.*, Dougherty J.D*, Heiman M., Schmidt E. F., Stevens T. R., Ma G., Bupp S., Shrestha P., Shah R. D., Doughty M. L., Gong S., Greengard P., Heintz N. (2008) Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 135, 749-62.
  3. Nakano, I.*, Dougherty, J.D.*, Kim, K., Klement, I., Geschwind, D. H., and Kornblum, H. I. (2007). Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells 25, 1975-1984.
  4. Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., and Wu, H. (2006). PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A 103, 111-116.
  5. Dougherty, J. D., Garcia, A. D., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E. M., Sofroniew, M. V., Kornblum, H. I., and Geschwind, D. H. (2005). PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci 25, 10773-10785.
  6. Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., and Black, D. L. (2005). Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol 25, 10005-10016.
  7. Nakano, I., Paucar, A. A., Bajpai, R., Dougherty, J. D., Zewail, A., Kelly, T. K., Kim, K. J., Ou, J., Groszer, M., Imura, T., et al. (2005). Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol 170, 413-427.
  8. Fox, I. J., Paucar, A. A., Nakano, I., Mottahedeh, J., Dougherty, J. D. & Kornblum, H. I. Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones–implications for stem cell biology. Brain research. Developmental brain research 153, 121-125, (2004).
  9. Easterday MC, Dougherty J.D., Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI (2003) Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol 264:309-322.
  10. Geschwind, D. H., Ou, J., Easterday, M. C., Dougherty, J. D, Jackson, R. L., Chen, Z., Antoine, H., Terskikh, A., Weissman, I. L., Nelson, S. F., and Kornblum, H. I. (2001). A genetic analysis of neural progenitor differentiation. Neuron 29, 325-339