Publications

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Last manual update (06/01/17) of work published since starting at Wash U:

  1. Chen, W.V., Nwakeze, C.L., Denny, C.A., O’Keeffe, S., Rieger, M.A., Mountoufaris, G., Kimer, A., Dougherty, J.D., Hen, R., Wu, Q., Maniatis, T. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (2017). doi: 10.1126/science.aal3231
  2. Sakers, K., Lake, A.M., Khazanchi, R., Ouwenga, R., Vasek, M.J., Dani, A., Dougherty, J.D. Astrocytes locally translate transcripts in their peripheral processes. Proceedings of the National Academy of Sciences (2017). doi: 10.1073/pnas.1617782114
  3. Hoye, M.L, Koval E.D., Wegener, A.J., Hyman, T.S., Yang, C., O’Brien, D.R., Miller R.L., Cole, T., Schoch, K.M., Shen, T., Kunikata, T., Richard, J.P., Gutmann D.H., Maragakis N.J., Kordasiewicz, H.B., Dougherty, J.D., Miller, T.M. microRNA profiling reveals marker of motor neuron disease in ALS modelsJournal of Neuroscience (2017). doi: 10.1523/JNEUROSCI.3582-16.2017
  4. Dalal, J.S., Yang, C. Sapkota, D., Lake, A.M., O’Brien, D.R., Dougherty, J.D. Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural CellsFrontiers in Molecular Neuroscience (2017). doi: 10.3389/fnmol.2017.00009
  5. Maricque, B. B, Dougherty, J. D., Cohen, B. A. A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells. Nucleic Acids Research (2016). doi links to a dysfunctional NAR page at this time; however, an open-access copy is available through Washington University here.
  6. Deming, Y., Black, K., Carrell, D., Cai, Y., Del-Aguila, J. L., Fernandez M. V., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Huang, K. L., Sutphen, C. L., Tarawneh, R., Fagan, A. M., Holtzman, D. M., Morris, J. C., Goate, A. M., Dougherty, J. D., Cruchaga, C. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. BMC Neurology (2017). doi:10.1186/s12883-016-0742-9
  7. Rieger, M. A. and Dougherty, J. D. Analysis of within Subjects Variability in Mouse Ultrasonic Vocalization: Pups Exhibit Inconsistent, State-Like Patterns of Call Production. Frontiers in Behavioral Neuroscience (2016). doi:10.3389/fnbeh.2016.00182
  8. O’Connor, S. D., Cabrera, O. H., Dougherty, J. D., Singh, S., Swiney, B. S.,Salinas-Contreras, P., Farber, N. B., and Noguchi, K. K. Dexmedetominidine Protects Against Glucocorticoid Induced Progenitor Cell Apoptosis in Neonatal Mouse Cerebellum. The Journal of Maternal-Fetal & Neonatal Medicine (2016). doi:10.1080/14767058.2016.1241763
  9. Reddy, A. S., O’Brien, D., Pisat, N., Weichselbaum, C. T., Sakers, K., Lisci, M., Dalal, J. S., and Dougherty, J. D. A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain. Biological Psychiatry (2016). doi:10.1016/j.biopsych.2016.02.021
  10. Usui, N., Co, M., Harper, M., Rieger, M. A., Dougherty, J. D., and Konopka, G. Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development. BPS (2016). doi:10.1016/j.biopsych.2016.02.008
  11. Wells, A., Kopp, N., Xu, X., O’Brien, D. R., Yang, W., Nehorai, A., Adair-Kirk, T. L., Kopan, R., and Dougherty, J. D. The Anatomical Distribution of Genetic Associations. Nucleic Acids Research 43, no. 22 (2015): 10804–10820. doi:10.1093/nar/gkv1262
  12. Kopp, N., Climer, S., and Dougherty, J. D. Moving From Capstones Toward Cornerstones: Successes and Challenges in Applying Systems Biology to Identify Mechanisms of Autism Spectrum Disorders. Frontiers in Genetics 6, (2015): 301. doi:10.3389/fgene.2015.00301
  13. Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H.-C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R., and Konopka, G. FoxP1 Orchestration of ASD-Relevant Signaling Pathways in the Striatum. Genes & Development 29, no. 20 (2015): 2081–2096. doi:10.1101/gad.267989.115
  14. Gockley, J., Willsey, A. J., Dong, S., Dougherty, J. D., Constantino, J. N., and Sanders, S. J. The Female Protective Effect in Autism Spectrum Disorder Is Not Mediated by a Single Genetic Locus. Molecular Autism 6, (2015): 25.
  15. Maloney, S. E., Khangura, E., and Dougherty, J. D. The RNA-Binding Protein Celf6 Is Highly Expressed in Diencephalic Nuclei and Neuromodulatory Cell Populations of the Mouse Brain. Brain Structure and Function (2015). doi:10.1007/s00429-015-1005-z
  16. Tupal, S., Rieger, M.A., Ling, G, Park, T.J., Dougherty, J.D., Goodchild, A.K., & Gray, P.A. Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors. Eur. J. Neurosci 40(7), (2015). doi:10.1111/ejn.12669
  17. Yuan, H. & Dougherty, J. D. Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association. Autism Res, 7:2, (2014). PMID: 24574247
  18. Xu, X., Wells, A. B., O’Brien, D. R., Nehorai, A. & Dougherty, J. D. Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders. J Neurosci 34, 1420-1431, (2014). PMID: 24453331
  19. Gorlich, A., Antolin-Fontes, B., Ables, J. L., Frahm, S., Slimak, M. A., Dougherty, J. D. & Ibanez-Tallon, I. Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons. Proc Natl Acad Sci U S A 110, 17077-17082, (2013). PMID: 24082085
  20. Foo, L. C. & Dougherty, J. D. Aldh1L1 is expressed by postnatal neural stem cells in vivo. Glia 61, 1533-1541, (2013). PMID: 23836537
  21. Dalal J., Roh J.H., Maloney S.E., Akuffo A., Shah S., Yuan H., Wamsley B., Jones W.B., Strong C.D., Gray P.A., Holtzman D.M., Heintz N., Dougherty J.D.  (2013) Genes &  Development Dalal 2013
  22. Dougherty J.D., Maloney SE, Wozniak DF, Rieger MA, Sonnenblick L, Coppola G, Mahieu NG, Zhang J, Cai J, Patti GJ, Abrahams BS, Geschwind DH, Heintz N (2013) The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. Journal of Neuroscience. Feb 13;33(7):2732-2753 Dougherty 2013
  23. Tryon R.C., Pisat N., Johnson S.L., Dougherty J.D. (2013) Development of translating ribosome affinity purification for zebrafish. GenesisTyron
  24. Dougherty, J.D., Fomchenko, E.I., Afua A. Akuffo, Schmidt, E., Helmy, K.Y., Bazzoli, E., Brennan, C.W., Holland, E.C., and Milosevic, A. (2012). Candidate pathways for promoting differentiation and quiescence in of oligodendrocyte progenitor-like cells in glioblastoma. Cancer Research, Sep 15;72(18):4856-68.Dougherty 2012 Cancer Res
  25. Dougherty, J.D., Zhang, J., Feng, H., Gong, S., and Heintz, N. (2012). Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. PLoS One 7, e40511.Dougherty 2012 Plos One
  26. Tien, A.C., Tsai, H.H., Molofsky, A.V., McMahon, M., Foo, L.C., Kaul, A., Dougherty, J.D., Heintz, N., Gutmann, D.H., Barres, B.A., Rowitch, D.A.. (2012). Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development 139, 2477-2487.
  27. Fomchenko, E.I., Dougherty, J.D., Helmy, K.Y., Katz, A.M., Pietras, A., Brennan, C. Husel, J.T., Milosevic, A., and Holland, E.C. (2011).  Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionPlos One, 6(7): e20605

Joe’s work pre-dating the lab:

  1. Dougherty, J. D., Schmidt, E.F., Nakajima, M., and Heintz, N. (2010). Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38, 4218-4320.
  2. Doyle J. P.*, Dougherty J.D*, Heiman M., Schmidt E. F., Stevens T. R., Ma G., Bupp S., Shrestha P., Shah R. D., Doughty M. L., Gong S., Greengard P., Heintz N. (2008) Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 135, 749-62.
  3. Nakano, I.*, Dougherty, J.D.*, Kim, K., Klement, I., Geschwind, D. H., and Kornblum, H. I. (2007). Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells 25, 1975-1984.
  4. Groszer, M., Erickson, R., Scripture-Adams, D. D., Dougherty, J. D., Le Belle, J., Zack, J. A., Geschwind, D. H., Liu, X., Kornblum, H. I., and Wu, H. (2006). PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A 103, 111-116.
  5. Dougherty, J. D., Garcia, A. D., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E. M., Sofroniew, M. V., Kornblum, H. I., and Geschwind, D. H. (2005). PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci 25, 10773-10785.
  6. Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., and Black, D. L. (2005). Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol 25, 10005-10016.
  7. Nakano, I., Paucar, A. A., Bajpai, R., Dougherty, J. D., Zewail, A., Kelly, T. K., Kim, K. J., Ou, J., Groszer, M., Imura, T., et al. (2005). Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol 170, 413-427.
  8. Fox, I. J., Paucar, A. A., Nakano, I., Mottahedeh, J., Dougherty, J. D. & Kornblum, H. I. Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones–implications for stem cell biology. Brain research. Developmental brain research 153, 121-125, (2004).
  9. Easterday MC, Dougherty J.D., Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI (2003) Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol 264:309-322.
  10. Geschwind, D. H., Ou, J., Easterday, M. C., Dougherty, J. D, Jackson, R. L., Chen, Z., Antoine, H., Terskikh, A., Weissman, I. L., Nelson, S. F., and Kornblum, H. I. (2001). A genetic analysis of neural progenitor differentiation. Neuron 29, 325-339.

 

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