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October 2022

Emma Farley, PhD
Assistant Professor
Department of Medicine
University of California-San Diego

October 13 @ 12:00 pm - 1:00 pm

presents, "Affinity optimizing enhancer variants disrupt development" Hosted by: Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC) Talk abstract:  An emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression during development. Here we discover that affinity optimizing single-nucleotide variants can violate this principle, disrupt tissue-specific gene expression, and alter phenotypes in Ciona, mice, and humans.

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January 2023

Francesca Luca, PhD
Professor
Center for Molecular Medicine and Genetics
Wayne State University School of Medicine

January 12, 2023 @ 12:00 pm - 1:00 pm

presents, "Genetic, developmental and social factors in immune cell gene expression and asthma" Hosted by:  Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC)

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May 2023

Lacra Bintu, PhD
Assistant Professor of Bioengineering
Department of Bioengineering
Stanford University

May 11, 2023 @ 12:00 pm - 1:00 pm

presents, "The sequence determinants of human transcriptional activators and repressors: high-throughput discovery and systematic perturbations" Hosted by:  Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC)

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