Postdoctoral positions to study the role of glial/axonal metabolic interactions in neurodegenerative disorders.

 

We invite highly motivated candidates to apply for positions as postdoctoral fellows in the laboratory of Dr. Jeff Milbrandt in the Department of Genetics at Washington University in St. Louis. Our primary goal is to unravel the mechanism of axon degeneration and its role in neurodegenerative disease.  Many of our projects are with my colleague Dr. Aaron DiAntonio and focus on understanding the role of NAD-regulated processes as well as mitochondrial dysfunction in axon stability. One set of studies is aimed at determining how the NADase activity of the TIR domain protein SARM1 is regulated and how its activity influences downstream signaling pathways that control axon maintenance. Another area of interest concerns the role of glia in supporting axon health; in particular, the effects of abnormal glial metabolism on axon integrity. These projects utilize a wide breadth of technologies from single cell sequencing to mass spectrometry to high throughput, quantitative imaging.  In addition, we use human genetics, AAV viral therapies, and disease models including mutant mice iPSC-derived neurons to further understand neurodegenerative processes.  These projects are funded by multiple grants from the NIH.

Full-time positions are available immediately and are funded for up to three years, with the possibility of extension.

Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology, neuroscience or genomics.
3. Good communication skills
4. In addition, applicant must be able to visit St. Louis for potential interviews

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at axonal@genetics.wustl.edu.

EOE:

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Postdoctoral positions focused on analyzing genetic variants associated with neurodevelopmental disorders using quantitative imaging and single cell genomics

 

The laboratories of Drs. Jeff Milbrandt and Rob Mitra invite highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will develop research programs in Personalized Medicine aimed at revealing the pathogenic mechanisms of disease-associated variants via monitoring phenotypic changes of genetically perturbed iPSC-derived neurons and glia. The primary goal of our collaborative, multidisciplinary group is to understand the mechanistic basis of genetic abnormalities that result in neurodevelopmental, neuropsychiatric, or neurodegenerative disorders. To address these questions, we use a novel multi-omics approach that integrates high-throughput imaging and machine learning methods with CRISPR/Cas9 screens and saturation mutagenesis to answer central questions about the pathophysiology that results from genetic mutations in chromatin regulators, mitochondrial proteins, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate key findings using banked patient samples.  Multiple full-time positions are available immediately and are funded for up to three years, with the possibility of extension.

Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology or genomics.
3. Programming skills (Python and R) are preferred
4. Good communication skills
5. In addition, applicant must be able to visit St Louis for potential interviews

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at MorphNSort@genetics.wustl.edu.

EOE:

Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

Postdoctoral Fellowships

 

The Department of Genetics is at the forefront of the rapidly developing field known as Genomic (or Personalized) Medicine, in which genetic and epigenetic analysis coupled with clinical information enables treatments to be tailored specifically to the individual patient. The rapid evolution of sequencing technologies, automated cellular imaging, and mass spectrometry methods to rapidly perform proteomic and metabolomics studies, coupled with powerful computational tools, is revolutionizing the biological sciences. Investigators in the department are developing new methods of genomic analysis including technology and software development, epigenomics, and copy number variation as well as studies of disease pathways using model organisms, to identify and study genes responsible for human disease and treatment responses. The department supports a broad program of preclinical and graduate instruction in genetics, with research opportunities ranging from studies of transcriptional networks, population genetics, protein evolution, neurological disorders, developmental genetics, models of human disease, genome architecture, statistical genetics and computational biology, genome technologies, and infertility. We are seeking outstanding young scientists to join our team. Please direct your application to one of the following faculty, or see here for currently posted open positions.

Model organism genetics:
Susan Dutcher: centriole duplication and tubulin isoforms
Heather Lawson: genetic architecture of metabolic traits
Zachary Pincus: aging and robustness in C. elegans
Tim Schedl: germ cell development in C. elegans
Jim Skeath: neurodevelopment in Drosophila

Genomics:
Barak Cohen: regulatory genomics
Jeff Milbrandt: metabolic control of axonal/glial interactions
Rob Mitra: technology development for systems biology
Samantha Morris: single cell sequencing and cell fate regulatory networks
Gary Stormo: computational biology of DNA
Ting Wang: epigenomics and computational biology

Statistical Genomics:
Michael A. Province: statistical methods, complex modeling, study design, complex traits
Nancy Saccone: complex diseases, quantitative methods

Applicants should send a CV and the names and contact information of three referees to one of these faculty members.