Positions Available

Postdoctoral position: To understand the molecular basis of transcription factor cooperativity and function.

The laboratory of Rob Mitra invites mature, highly motivated candidates to apply for positions as postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will seek to understand how different members of the basic helix-loop-helix transcription factor family achieve their specificities. Our research to date suggests that complex cooperative interactions with other transcription factors play a major role in determining this specificity, and fellows will seek to characterize these interactions and understand the fundamental principles that underlie this phenomenon. Experiments will be performed in mammalian and yeast cells.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

The ideal applicants will have:

  1. PhD or MD/PhD in biological sciences or related fields.
  2. Experience in molecular biology, genomics, or yeast genetics.
  3. Candidates with programming skills will be given priority (Python and R are preferred).
  4. Good spoken and written communication skills.
  5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

How to Apply:

Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Rob Mitra at rmitra@wustl.edu.

Postdoctoral position: To develop an inducible molecular memory system to record transient states of CNS cells.

The laboratories of Rob Mitra and Joe Dougherty invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will develop and apply methods based on the novel ‘Calling Cards’ technology that is able to record the genome-wide interactions of any DNA-binding protein (e.g. a specific transcription factor, or a general transcriptional mediator), creating a permanent molecular memory of all binding events that occur at a given moment or epoch. This technology allows transient molecular interactions to be captured non-destructively, during a controlled window in time, and then read out at a later point in time. This methodology has been developed in vitro, and successful applicants will adapt the technology for use in the brain to provide the community with a versatile toolbox that can be applied to a number of outstanding problems.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

The ideal applicants will have:

  1. PhD or MD/PhD in biological sciences or related fields.
  2. Experience in molecular biology or genomics.
  3. Candidates with programming skills will be given priority (Python and R are preferred).
  4. Good spoken and written communication skills.
  5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

How to Apply:

Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Rob Mitra and Joe Dougherty at rmitra@wustl.edu, jdougherty@genetics.wustl.edu.

Postdoctoral positions to develop methods to drive differentiation of fibroblasts and iPSCs into glial and neuronal subtypes using Cas9/CRISPR technology.

The laboratories of Jeff Milbrandt and Rob Mitra invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will explore the use and optimization of Cas9 proteins as RNA-guided, artificial transcription factors (ATFs). Cas9-based ATFs will then be used to drive differentiation of fibroblasts and/or modified iPSCs into glial and neuronal subtypes. These cells, either harboring disease-associated variants or wildtype, will be used in targeted drug and genetic screens to identify and modulate pathways that are central to pathophysiology of neurodegenerative disease phenotypes. This project is funded by a grant from the NIH.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

The ideal applicants will have:

  1. PhD or MD/PhD in biological sciences or related fields
  2. Experience in molecular biology or genomics.
  3. Candidates with programming skills will be given priority (Python and R are preferred)
  4. Good spoken and written communication skills
  5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

How to Apply:

Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at cas9project@genetics.wustl.edu.

 

Additional Positions Available:

  • There are positions available for graduate students interested in experimental and/or computational biology.
  • There is a position available for a technician with prior experience in molecular biology.
  • In addition, the following position is available:(1) There is a position available for a postdoctoral fellow with experience in molecular biology and interest in genomic technology development. Experience in cancer biology is a plus.

To apply for a technician position or either of the postdoctoral fellow positions, please send a cover letter describing your research interests, CV, and three letters of reference to:

Prof. Rob Mitra
Department of Genetics
Washington University
School of Medicine
4444 Forest Park
Campus Box 8510
St. Louis, MO 63108
Email: rmitra[at]genetics.wustl.edu

Note to applicants for postdoctoral positions: please apply a minimum of three months in advance of when you would be available to start work on a full-time basis.