Dr. Jeff Milbrandt, MD, PhD, James S. McDonnell Professor, head of the Department of Genetics, and executive director of the McDonnell Genome Institute at Washington University School of Medicine, and Dr. Aaron DiAntonio, the Alan A. and Edith L. Wolff Professor of...
The Genome Engineering and iPSC Center (GEiC) and the Milbrandt and DiAntonio Labs at Washington University School of Medicine collaborated on a paper published in Experimental Neurology, “SARM1 is required in human derived sensory neurons for injury-induced and...
The Milbrandt Lab collaborated on a paper with the Wu Lab from Harvard Medical School and the DiAntonio Lab at Washington University School of Medicine, “Multiple domain interfaces mediate SARM1 autoinhibition.” Chen Shen, a postdoc in the Wu Lab, is lead...
The Milbrandt and DiAntonio Labs have a new paper in eLife, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
Eli Lilly & Company recently acquired Disarm Therapeutics, a pre-clinical NAD-boosting company treating neuropathy and neurodegenerative diseases, for $135 million and a potential additional $1.2 billion in milestones. Disarm was founded by Atlas Venture; Jeff...
The DiAntonio and Milbrandt Labs published a paper in the Journal of Cell Biology, “SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.” Kwang Woo Ko, a postdoc in the DiAntonio Lab, is lead author on the...
The Buchser, DiAntonio, and Milbrandt Labs have published a paper in Scientific Data, “Domain-centric database to uncover structure of minimally characterized viral genomes.” Jack Bramley, a lead scientist in the Buchser Lab, is lead author on the paper. ...
The Milbrandt and DiAntonio Labs have a new preprint, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
The Milbrandt Lab had a paper published recently in Molecular Neurobiology. The paper, “DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration,” was published in...
Jeffrey Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at Washington University School of Medicine, is a senior author on a new paper from the DiAntonio Lab recently published in JCI Insight. The paper,...
The Milbrandt and DiAntonio Labs published a paper recently in Science, “TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.” Kow Essuman, Ph.D., a graduate student in the Milbrandt Lab, is a lead author on the paper....
Jeffrey Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics, and Aaron DiAntonio, M.D., Ph.D., the Alan A. and Edith L. Wolff Professor of Developmental Biology, will co-lead the new Needleman Center for...
The Milbrandt and DiAntonio labs had a paper published recently on gene therapy that blocks peripheral damage in mice. The paper, “Gene therapy targeting SARM1 blocks pathological axon degeneration in mice,” appears in a recent issue of the Journal of...
