March 14, 2022: Congratulations to Dr. Elena Minakova on being awarded the American Federation of Medical Research Scholar Award at the Eastern Medical Research, for her outstanding work on how ontogenetic oxycodone exposure affects developing and adult mice! March 3,...
Francis Collins, MD, PhD, Director of NIH, recently wrote a blog post that spotlights calling cards technology being developed by the Dougherty and Mitra Labs. As Collins writes about calling cards in the post: “These comprehensive maps allow (researchers) to...
The Dougherty Lab had a paper published in Translational Psychiatry, “Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.” Bernie Mulvey, a grad student in the lab, is lead author on...
The Dougherty Lab has a new preprint, “A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.” Tomás Lagunas Jr, a graduate student in the lab, is lead author on the...
The Dougherty Lab has a new preprint, “Functional connectivity of the developing mouse cortex.” Rachel Rahn, a graduate student in the lab, is lead author. Congratulations, all!
The Dougherty Lab has a new preprint, “Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model.” Kayla Nygaard, a graduate student in the lab, is lead author on the preprint. Congratulations, all!
The Dougherty Lab has a new paper published in the Journal of Neurodevelopmental Disorders, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint....
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint. David Gutmann, MD, PhD, Director, Washington...
The Dougherty Lab published a paper in Nature Communications, “Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.” Lead author is Kristina Sakers, PhD, a former graduate student in the...
The Dougherty Lab has a new preprint, “Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays.” Bernie Mulvey, a grad student in the lab, is first author. Joe Dougherty, PhD, Associate...
The Dougherty Lab contributed to a new paper published in Science Advances, “Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.” Andrew Luskin, a former graduate student in the Department of Anesthesiology at Washington...
The Dougherty Lab has a new paper in Behavioral Neuroscience, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, Assistant Professor of Pediatrics at...
Mike Rieger, a former grad student in the Dougherty Lab, had a paper published in Cell Reports, “CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3′ UTR Elements.” Members...
Mike Vasek, a postdoc in the Dougherty Lab, has a new preprint, “Microglia perform local protein synthesis at perisynaptic and phagocytic structures.” Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of...
Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of Medicine, won Best Mentor of the Year at the WashU 2020 Neuroscience Awards. Congratulations, Dr. Dougherty!
Jason Yi, Assistant Professor of Neuroscience at Washington University School of Medicine, and Susan Maloney, PhD, Assistant Professor of Psychiatry at Washington University School of Medicine and a member of the Dougherty Lab in the Department of Genetics, are...
The Dougherty Lab has a new preprint, “A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.” The preprint shares the lab’s work on the MYT1L gene and its...
The Dougherty Lab contributed to a paper by the Gabel Lab in Cell Reports, “DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.” Diana Christian and Dennis Wu, graduate...
The Dougherty Lab published a review in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.” Bernie Mulvey and Tomás Lagunas Jr., graduate students in the lab, are lead...
The Dougherty Lab has a new preprint, “Identification of compounds enhancing Aqp4 stop codon readthrough.” Darshan Sapkota, a postdoc in the lab, is lead author. Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University...
Tomás Lagunas Jr, a graduate student in the Dougherty Lab, recently won the student presentation award in Genetics at the SACNAS 2020 conference. The SACNAS organization is “dedicated to fostering the success of Chicanos/Hispanics and Native Americans, from...
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor of...
The Dougherty Lab has a new preprint, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, a collaborating researcher in the lab and a a neonatologist at...
Simona Sarafinovska, a graduate student in the Dougherty Lab, received an abstract award for the International Society for Developmental Psychobiology (ISDP) 2020 conference to give an oral presentation on the lab’s findings on “Effects of Ontogenetic Oxycodone...
Tomás Lagunas Jr., a graduate student in the Dougherty Lab, recently won the Early Career Investigator Program award from World Congress of Psychiatric Genetics. He will be attending both WCPG 2020 virtually and WCPG 2021 in Montreal. Congratulations, Tomás!
The Dougherty Lab has a new preprint, “TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo.” The work was done in collaboration with the Lawson Lab. Yating Liu, a...
Tomás Lagunas Jr., a graduate student in the Dougherty Lab, will be giving an oral presentation and was awarded the registration scholarship for the 2020 Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) virtual conference....
The Mitra Lab recently published a paper in Cell, “Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cell.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author on the paper....
Bernie Mulvey, a graduate student in the Dougherty Lab, received an extremely generous travel award to remotely attend the 2020 American College of Neuropsychopharmacology conference, and to attend the 2021 ACNP conference in person. Congratulations, Bernie!
Kelli McFarland White has joined the Dougherty Lab as research lab supervisor. Kelli will work closely with Darshan Sapkota, a postdoc in the lab, on research, and also take on an organizational role to make operations in the molecular lab as efficient as possible....
The Wang Lab and Dougherty Lab published a paper recently in Science Advances, “DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods.” Yu He, a former graduate student in the...
Chengran Yang, a former graduate student in the Dougherty Lab, is lead author on a new preprint, “Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traits.” Congratulations, Chengran!
The Dougherty Lab recently published a paper in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants across Biological Contexts.” Bernie Mulvey, a graduate student in the lab, is first author. Tomás...
The Dougherty Lab published a paper in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences.” Nathan Kopp, a former graduate student in the lab, and Kayla...
Susan Maloney, PhD, a member of the Dougherty Lab, was recently promoted to Assistant Professor in Psychiatry at Washington University School of Medicine. Congratulations, Dr. Maloney!
The Dougherty Lab published a new paper in Brain and Behavior, “The trajectory of gait development in mice.” Shyam Akula, a former undergraduate researcher in the lab, is first author on the paper. Joe Dougherty, PhD, Associate Professor of Genetics at...
The Dougherty Lab recently had a paper published in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences.” Nathan Kopp, PhD, a former graduate student in the...
Jelani Deajon-Jackson, an undergraduate student in the Dougherty Lab, was recently awarded a BioSURF fellowship by Washington University in St. Louis to train with his mentor Mike Vasek, a postdoc in the lab. The Washington University Biology Summer Undergraduate...
Shyam Akula, a Dougherty Lab alum and a graduate student in the MSTP program at Harvard/MIT recently received a Paul & Daisy Soros Fellowship. Congratulations, Shyam! Read more about him and the fellowship here.
The Dougherty and Mitra Labs had a paper published in PNAS, “A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues.” Alex Cammack, a graduate student in the Miller Lab who recently defended, is first author on the paper....
The Dougherty Lab has a new preprint, “Activity-dependent translation in astrocytes.” Darshan Sapkota, a postdoc in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor in the Department of Genetics at Washington University...
The Dougherty Lab recently had a paper published in Scientific Reports, “CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system.” Yating Liu, a programmer in the lab, is an author on the paper,...
The Dougherty Lab has a new preprint, “CRISPR-TRAPSeq identifies the QKI RNA binding protein as important for astrocytic maturation and control of thalamocortical synapses.” Kristina Sakers, PhD, a former graduate student in the lab, is first author on the...
The Dougherty Lab has a new preprint in collaboration with Dionnet Bhatti’s lab at Harvard. The preprint, “Extended amygdala-parabrachial circuits alter threat assessment to regulate feeding,” includes authors Bernie Mulvey, a grad student in the...
The Dougherty Lab has a new paper in Neural Development, “An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells.” Darshan Sapkota, a postdoc in the lab, is first author on the paper. Joe Dougherty, PhD,...
Tomás Lagunas, Jr., and Bernie Mulvey, graduate students in the Dougherty Lab, recently added a preprint edition review of their MPRA technique for use in neuropsychiatric genetics to Biorxiv. Congratulations, Tomás and Bernie!
The Dougherty Lab recently welcomed new members including Rachael, a senior graduate student who will be working with Kayla Nygaard, a graduate student in the lab; Chayla, a first year PhD rotation student working with Bernie Mulvey, a graduate student in the lab;...
The Dougherty Lab has a new preprint, “The Oft-Overlooked Massively Parallel Reporter Assay: Where, When, and Which Psychiatric Genetic Variants are Functional?” Bernie Mulvey, a graduate student in the lab, is first author on the preprint. Tomás Lagunas...
The Dougherty Lab had a paper published recently in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models,” thoroughly defines a set of...
The Dougherty Lab recently presented at the annual Society for Neuroscience meeting in Chicago. Dr. Susan Maloney, Instructor in Psychiatry and a member of the Dougherty Lab, presented on modeling social motivation in the mouse and the role of Shank3B and the oxytocin...
The Dougherty Lab has new preprint on the trajectory of gait development in mice. The preprint includes first author Shyam Akula, a graduate student at Harvard Medical School, and senior authors Joseph Dougherty, Ph,D., Associate Professor of Genetics at Washington...
Reshma Bhagat has joined the Dougherty Lab as a postdoc. Dr. Bhagat comes from a background studying molecular perturbations in neural cell types elicited by Zika virus components. Check out Dr. Bhagat’s work here.
Nathan Kopp, PhD, a graduate student in the Dougherty Lab at Washington University School of Medicine, recently had a paper published in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the...
Darshan Sapkota, Ph.D., a postdoctoral researcher in the Dougherty Lab, got funding for his K99 application. With this grant, Darshan will study the role of a new variant of Aquaporin 4 protein in brain function and Alzheimer’s disease. Aquaporin 4 is a water...
The Dougherty Lab published a paper recently in Genes, Brain and Behavior. The paper, “Celf6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning,” shows that the resistance to change by the Celf6 mutant in the...
The Dougherty Lab published a paper recently in Autism Research, “Erroneous inference based on a lack of preference within one group: Autism, mice, and the social approach task.” The paper looks at Erroneous Within‐group Only Comparisons, or EWOCs, a term...
The Dougherty Lab was recently awarded a pilot grant from the Center for Clinical Pharmacology for its project, “A new model to understand the developmental deficits associated with fetal exposure to opioids.” Principal Investigators are Ream Al-Hasani,...
Kayla Nygaard, a graduate student in the Dougherty Lab at Washington University School of Medicine in St. Louis, recently had a paper accepted for publication. The paper, “Erroneous inference based on a lack of preference within one group: autism, mice, and the...
Tomás Lagunas Jr, a graduate student in the Dougherty Lab, was invited to speak at Brown University for the inaugural Dr. Samuel M. Nabrit Conference for Early Career Scholars. Congratulations, Tomás! Read more about Tomás and his work in the Dougherty...
The Dougherty Lab has a new preprint, “A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.” The preprint proposes a collection of best practices to generate a highly-detailed molecular cell atlas of highly informative...
Susan Maloney, Ph.D., Instructor in Psychiatry and a member of the Dougherty Lab, recently had a first-author paper published in Scientific Reports. The paper, “Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the...
The Dougherty Lab has a new preprint, “Gtf2i and Gtf2ird1 mutation are not sufficient to reproduce mouse phenotypes caused by the Williams Syndrome critical region.” In the paper, first author Nathan Kopp, graduate student in the Dougherty Lab, disproves a...
Tomás Lagunas Jr., a graduate student in the Dougherty Lab in the Department of Genetics at Washington University School of Medicine in St. Louis, was recently named a fellow of the Yale Ciencia Academy for Career Development. The program gives graduate...
The Dougherty Lab recently had a paper published in Cell Reports. The paper, “Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain,” shows that alternative translation is widespread and...
The Dougherty lab recently shared its new preprint, “Erroneous inference based on a lack of preference within one group: autism, mice, and the Social Approach Task.” In the paper, the lab argues using statistical principles and data simulations that...
Darshan Sapkota, a postdoctoral researcher in the Dougherty lab, had a paper published recently on non-canonical translational events in CNS cell types in vitro and in vivo. The paper, “Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated...
Nathan Kopp, a graduate student in the lab of Joe Dougherty, Ph.D., Associate Professor in the Department of Genetics, recently was accepted to a dual clinical genetic counseling/postdoc position at UCLA. Congratulations, Nathan! Read more about Nathan and his work in...
The Dougherty lab had a paper published recently in eNeuro. The paper, “The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms,” suggests that differences in...
The Wang lab and the Dougherty lab had a paper published recently in Cell Reports. The paper, “Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome,” shows that PHF6-regulated genes are overrepresented in gene signatures and modules that...
Claire Weichselbaum, a graduate student in Dr. Joseph Dougherty’s lab, was recently featured in a segment on NPR’s St. Louis Public Radio. The on-air piece spotlighted “Brain Discovery,” a program that Weichselbaum co-founded with Brian...
The Dougherty Lab contributed to a paper with the Miller lab. The paper, “Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis,” appears in Brain. Read the abstract here.
The Dougherty lab published a paper recently in eNeuro. The paper, “Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure,” looks at how maternal fluoxetine treatment can induce behavioral disruptions in...
