Washington University announced in a recent press release that the National Academy of Inventors has elected Drs. Douglas Covey, Jeffrey Milbrandt, and Dan Moran to its 2021 cohort of fellows. The NAI fellowship is the highest professional distinction reserved solely...
Dr. Jeff Milbrandt, MD, PhD, James S. McDonnell Professor, head of the Department of Genetics, and executive director of the McDonnell Genome Institute at Washington University School of Medicine, and Dr. Aaron DiAntonio, the Alan A. and Edith L. Wolff Professor of...
The Buchser Lab has a new preprint, “Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen.” Lead authors include Alex Yenkin, a research technician in the lab, and Jack Bramley, a staff scientist in the lab....
The Genome Engineering and iPSC Center (GEiC) and the Milbrandt and DiAntonio Labs at Washington University School of Medicine collaborated on a paper published in Experimental Neurology, “SARM1 is required in human derived sensory neurons for injury-induced and...
The Milbrandt Lab collaborated on a paper with the Wu Lab from Harvard Medical School and the DiAntonio Lab at Washington University School of Medicine, “Multiple domain interfaces mediate SARM1 autoinhibition.” Chen Shen, a postdoc in the Wu Lab, is lead...
The Milbrandt and DiAntonio Labs have a new paper in eLife, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
The Buchser Lab has a new preprint, “Low-Cost Manually Assembled Open Source Reader for Isothermal Pathogen Detection from Saliva using RT-LAMP: SARS-CoV-2 Use Case.” Jack Bramley, a staff scientist in the lab, is lead author on the preprint. Senior...
Eli Lilly & Company recently acquired Disarm Therapeutics, a pre-clinical NAD-boosting company treating neuropathy and neurodegenerative diseases, for $135 million and a potential additional $1.2 billion in milestones. Disarm was founded by Atlas Venture; Jeff...
Jeffrey R. Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics at Washington University School of Medicine, and Robi Mitra, PhD, the Alvin Goldfarb Professor of Computational Biology and a professor of genetics at Washington...
The Mitra and Milbrandt Labs had a paper published recently in Genome Research, “High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation.” Matt Lalli,...
The Department of Genetics and McDonnell Genome Institute (MGI) at Washington University School of Medicine, in collaboration with biotech company Fluidigm, are developing a saliva test to detect the SARS-CoV-2 virus. Fluidigm this week received emergency use...
The DiAntonio and Milbrandt Labs published a paper in the Journal of Cell Biology, “SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.” Kwang Woo Ko, a postdoc in the DiAntonio Lab, is lead author on the...
The Buchser, DiAntonio, and Milbrandt Labs have published a paper in Scientific Data, “Domain-centric database to uncover structure of minimally characterized viral genomes.” Jack Bramley, a lead scientist in the Buchser Lab, is lead author on the paper. ...
The McDonnell Genome Institute, researchers at WashUMed, and Fluidigm have developed an extraction-free saliva-based test to detect the SARS‑CoV‑2 virus. It has an easy-to-administer protocol that does not require collection via a nasopharyngeal swab. “Rapid, reliable...
The Milbrandt Lab recently had a paper published in Nature Communications, “Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia.” Peter Wang and Aldrin K. Y. Yim, graduate students in the lab, are...
The Milbrandt Lab and the Mitra Lab and scientists at the McDonnell Genome Institute have a new preprint, “Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP.” Matt Lalli, a postdoc in the Milbrandt and Mitra Labs, is a...
The Milbrandt and DiAntonio Labs have a new preprint, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
Jeffrey Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics, and colleagues including William G. Powderly, MD, the J. William Campbell Professor of Medicine and director of the Institute for Clinical and Translational Sciences...
The Milbrandt Lab has a new preprint, “Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming.” Peter Wang, a postdoc in the lab, is first author on the preprint. Aldrin Yim, a graduate student in the lab, is also...
The Milbrandt Lab published a paper recently in Glia. The paper, “Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy,” shows that Schwann cells may play an important role in diabetic neuropathy and targeting...
The Milbrandt Lab had a paper published recently in Molecular Neurobiology. The paper, “DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration,” was published in...
Jeff Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at Washington University School of Medicine in St. Louis, was recently honored with a Distinguished Faculty Award at Washington University’s annual...
Jeffrey Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at Washington University School of Medicine, is a senior author on a new paper from the DiAntonio Lab recently published in JCI Insight. The paper,...
The Milbrandt and DiAntonio Labs published a paper recently in Science, “TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.” Kow Essuman, Ph.D., a graduate student in the Milbrandt Lab, is a lead author on the paper....
Jeffrey Milbrandt, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics, and Aaron DiAntonio, M.D., Ph.D., the Alan A. and Edith L. Wolff Professor of Developmental Biology, will co-lead the new Needleman Center for...
Jeff Milbrandt, M.D., Ph.D., James S. McDonnell Professor and head of the Department of Genetics, is helping usher in a new era at the McDonnell Genome Institute at Washington University School of Medicine in St. Louis. Milbrandt, who was recently appointed executive...
The Milbrandt and DiAntonio labs had a paper published recently on gene therapy that blocks peripheral damage in mice. The paper, “Gene therapy targeting SARM1 blocks pathological axon degeneration in mice,” appears in a recent issue of the Journal of...
Kow Essuman, a graduate student in Dr. Jeff Milbrandt’s lab in The Department of Genetics at Washington University School of Medicine, was recently named a Spencer T. and Ann W. Olin Medical Science Fellow. The Olin award recognizes outstanding achievement in...
The Milbrandt lab published a paper recently on Schwann cell O-GlcNAcylation. The paper, “Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN,” appears in PNAS. Sungsu Kim, Ph.D., an...
