The Dougherty Lab had a paper published in Translational Psychiatry, “Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.” Bernie Mulvey, a grad student in the lab, is lead author on...
The Dougherty Lab has a new preprint, “A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.” Tomás Lagunas Jr, a graduate student in the lab, is lead author on the...
The Dougherty Lab has a new preprint, “Functional connectivity of the developing mouse cortex.” Rachel Rahn, a graduate student in the lab, is lead author. Congratulations, all!
The Dougherty Lab has a new preprint, “Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model.” Kayla Nygaard, a graduate student in the lab, is lead author on the preprint. Congratulations, all!
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint. David Gutmann, MD, PhD, Director, Washington...
The Dougherty Lab published a paper in Nature Communications, “Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.” Lead author is Kristina Sakers, PhD, a former graduate student in the...
The Dougherty Lab has a new preprint, “Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays.” Bernie Mulvey, a grad student in the lab, is first author. Joe Dougherty, PhD, Associate...
The Dougherty Lab has a new paper in Behavioral Neuroscience, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, Assistant Professor of Pediatrics at...
Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of Medicine, won Best Mentor of the Year at the WashU 2020 Neuroscience Awards. Congratulations, Dr. Dougherty!
The Dougherty Lab has a new preprint, “A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.” The preprint shares the lab’s work on the MYT1L gene and its...
The Dougherty Lab contributed to a paper by the Gabel Lab in Cell Reports, “DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.” Diana Christian and Dennis Wu, graduate...
The Dougherty Lab published a review in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.” Bernie Mulvey and Tomás Lagunas Jr., graduate students in the lab, are lead...
The Dougherty Lab has a new preprint, “Identification of compounds enhancing Aqp4 stop codon readthrough.” Darshan Sapkota, a postdoc in the lab, is lead author. Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University...
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor of...
The Dougherty Lab has a new preprint, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, a collaborating researcher in the lab and a a neonatologist at...
The Mitra Lab recently had a paper accepted in Genome Research, “High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.” Matt Lalli, a postdoc in...
The Mitra Lab recently published a paper in Cell, “Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cell.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author on the paper....
The Wang Lab and Dougherty Lab published a paper recently in Science Advances, “DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods.” Yu He, a former graduate student in the...
The Dougherty Lab recently published a paper in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants across Biological Contexts.” Bernie Mulvey, a graduate student in the lab, is first author. Tomás...
The Dougherty Lab published a paper in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences.” Nathan Kopp, a former graduate student in the lab, and Kayla...
The Dougherty Lab published a new paper in Brain and Behavior, “The trajectory of gait development in mice.” Shyam Akula, a former undergraduate researcher in the lab, is first author on the paper. Joe Dougherty, PhD, Associate Professor of Genetics at...
The Dougherty Lab recently had a paper published in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences.” Nathan Kopp, PhD, a former graduate student in the...
The Dougherty Lab has a new preprint, “Activity-dependent translation in astrocytes.” Darshan Sapkota, a postdoc in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor in the Department of Genetics at Washington University...
The Dougherty Lab has a new preprint in collaboration with Dionnet Bhatti’s lab at Harvard. The preprint, “Extended amygdala-parabrachial circuits alter threat assessment to regulate feeding,” includes authors Bernie Mulvey, a grad student in the...
The Dougherty Lab has a new paper in Neural Development, “An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells.” Darshan Sapkota, a postdoc in the lab, is first author on the paper. Joe Dougherty, PhD,...
The Dougherty Lab has a new preprint, “The Oft-Overlooked Massively Parallel Reporter Assay: Where, When, and Which Psychiatric Genetic Variants are Functional?” Bernie Mulvey, a graduate student in the lab, is first author on the preprint. Tomás Lagunas...
The Dougherty Lab had a paper published recently in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models,” thoroughly defines a set of...
The Dougherty Lab recently presented at the annual Society for Neuroscience meeting in Chicago. Dr. Susan Maloney, Instructor in Psychiatry and a member of the Dougherty Lab, presented on modeling social motivation in the mouse and the role of Shank3B and the oxytocin...
Nathan Kopp, PhD, a graduate student in the Dougherty Lab at Washington University School of Medicine, recently had a paper published in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the...
Joe Dougherty, Ph.D, Associate Professor in the Department of Genetics at Washington University School of Medicine, is an author on a recently published paper, “A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.” The...
The Dougherty Lab published a paper recently in Genes, Brain and Behavior. The paper, “Celf6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning,” shows that the resistance to change by the Celf6 mutant in the...
The Dougherty Lab has a new preprint, “A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.” The preprint proposes a collection of best practices to generate a highly-detailed molecular cell atlas of highly informative...
The Calling Cards team in the Department of Genetics at Washington University School of Medicine in St. Louis had their preprint on self-reporting transposons selected for a prelight. The prelight contains additional insights about the paper from Arnav Moudgil, a...
The Dougherty Lab recently had a paper published in Cell Reports. The paper, “Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain,” shows that alternative translation is widespread and...
The Dougherty lab recently shared its new preprint, “Erroneous inference based on a lack of preference within one group: autism, mice, and the Social Approach Task.” In the paper, the lab argues using statistical principles and data simulations that...
Darshan Sapkota, a postdoctoral researcher in the Dougherty lab, had a paper published recently on non-canonical translational events in CNS cell types in vitro and in vivo. The paper, “Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated...
Nathan Kopp, a graduate student in the lab of Joe Dougherty, Ph.D., Associate Professor in the Department of Genetics, recently was accepted to a dual clinical genetic counseling/postdoc position at UCLA. Congratulations, Nathan! Read more about Nathan and his work in...
The Dougherty lab had a paper published recently in eNeuro. The paper, “The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms,” suggests that differences in...
The Wang lab and the Dougherty lab had a paper published recently in Cell Reports. The paper, “Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome,” shows that PHF6-regulated genes are overrepresented in gene signatures and modules that...
The Dougherty Lab contributed to a paper with the Miller lab. The paper, “Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis,” appears in Brain. Read the abstract here.
