presents, "Epigenetic regulation of human cortical development and its disruption to cause neurodevelopmental disorders" Talk abstract: Work in my laboratory focuses on modeling gene regulatory networks that control various aspects of human brain development. We are interested in identifying novel transcriptional and epigenetic regulators of these networks, defining mechanisms by which they control brain development, and studying how pathogenic mutations in genes encoding these regulators contribute to neurodevelopmental disorders. Hosted by:  Dr. Tristan Li In-person only:  Connor Auditorium (FLTC)

presents, "Epigenetic regulation and environmental adaptation" Talk abstract:  The Zhong laboratory is interested in how cellular machines sense intrinsic and extrinsic cues and alter chromatin landscapes to generate adaptive responses. They focus on epigenetic regulation by exploring how chromatin dynamics is established, maintained, erased, and inherited over time, and how altered chromatin modifications lead to improved plant traits and environmental adaptation. They combine functional genomics and high-throughput proteomics and genomics techniques together with genetic and biochemical tools to understand the function…

presents, "Cellular reprogramming to study neuronal lineage specification and develop cell therapies for the brain" Talk title: I will talk about neuronal cell specification centered around transcription factor regulation and applications of microglia replacement therapies. Hosted by:  Dr. Joe Dougherty In-person only:  Connor Auditorium (FLTC)

presents, "Negative impacts of chromosome 21 gene dosage on primary cilia formation and signaling" Talk abstract:  Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Our work reveals that elevated Pericentrin from trisomy 21 disrupts multiple early steps of ciliogenesis and creates persistent trafficking defects in ciliated cells and in a mouse model of Down syndrome. Hosted by:  Dr. Susan Dutcher In-person only: …

presents, "Title TBD" Hosted by:  Dr. Brett Maricque In-person only:  Connor Auditorium (FLTC)

presents, "Role of African Ancestry in genomic and proteomic changes in breast cancer disparities" Hosted by:  Alla Karpova and Genetics trainees & postdocs In-person only:  Connor Auditorium (FLTC)

presents, "The RASopathies: Too much, too little and getting to just right" Talk abstract:  Noonan syndrome and the related disorders, now called the RASopathies, are phenotypically related traits arising from perturbations, largely engendering gain of function, in the RAS/mitogen-activated protein kinase signal transduction pathway. In this lecture, insights gained from phenotype-first and genotype-first studies of the RAsopathies will be provided as well as those from cell and animal model research, informing the development of mechanistic therapies for these genetic traits.…

presents, "Mitotic centrosomes: assembly & functions" Hosted by:  Dr. Susan Dutched In-person only:  Connor Auditorium (FLTC)

presents, "Fitting the pieces together: how cells make centrosomes and cilia" Hosted by:  Dr. Tychele Turner In-person only:  Connor Auditorium (FLTC)

presents, "Title TBD" Hosted by:  Dr. Heather Lawson In-person only:  Connor Auditorium (FLTC)

presents, "Functional analysis of autism risk genes in zebrafish" Hosted by:  Dr. Joe Dougherty In-person only:  Connor Auditorium (FLTC)

presents, "Mapping the regulatory wiring of the genome to connect disease variants to functions" Hosted by:  Dr. Heather Lawson In-person only:  Connor Auditorium (FLTC)

presents, "The sequence determinants of human transcriptional activators and repressors: high-throughput discovery and systematic perturbations" Hosted by:  Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC)

presents, "Genomics of developmental brain anomalies" Hosted by:  Dr. Peter Jin In-person only:  Connor Auditorium (FLTC)

presents, "Protein-protein proximity networks reveal therapeutic vulnerabilities in cancer" Hosted by:  Dr. Tychele Turner In-person only:  Connor Auditorium (FLTC)