The Lawson Lab has a new preprint, “Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression.” Celine St. Pierre, a graduate student in the lab, is first author. Congratulations, all!
Ting Wang, PhD, the Sanford C. and Karen P. Loewentheil Distinguished Professor of Medicine at Washington University School of Medicine, was recently named as leader for part of the Data Coordinating Center for the new Impact of Genomic Variation on Function (IGVF)...
The Wang Lab has contributed to two new papers. The first, “Epigenetic therapies in ovarian cancer alter repetitive element expression in a TP53-dependent manner,” was recently published in Cancer Research. The second, “OCT4 cooperates with distinct...
The Cohen Lab has a new preprint, “A Test of the Pioneer Factor Hypothesis.” Jeff Hansen, a grad student in the lab, is lead author. Congratulations, all!
Francis Collins, MD, PhD, Director of NIH, recently wrote a blog post that spotlights calling cards technology being developed by the Dougherty and Mitra Labs. As Collins writes about calling cards in the post: “These comprehensive maps allow (researchers) to...
The Dougherty Lab had a paper published in Translational Psychiatry, “Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.” Bernie Mulvey, a grad student in the lab, is lead author on...
The Wang Lab contributed to a paper published in Genomics, Proteomics & Bioinformatics, “AIAP: A Quality Control and Integrative Analysis Package to Improve ATAC-seq Data Analysis.” Congratulations, all!
The Lawson Lab has a new preprint, “Integrated transcriptomics identifies β-cell subpopulations and genetic networks associated with obesity and glycemic control in SM/J mice.” Congratulations, all!
The Turner Lab had a paper published in Human Genomics, “Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism.” Congratulations, all!
The Dougherty Lab has a new preprint, “Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process.” Congratulations, all!
The Cohen Lab collaborated with the Rubin Lab on a new preprint, “p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis.” Nathan Rockwell, a grad student in the Rubin Lab, is lead author on the preprint. Congratulations, all!
The Jin Lab collaborated on a paper published in JAMA Neurology, “DIAPH1 Variants in Non–East Asian Patients With Sporadic Moyamoya Disease.” Congratulations, all!
The Mollah Lab has a new preprint, “NeTOIF: A Network-based Approach for Time-Series Omics Data Imputation and Forecasting.” Min Shi, a postdoc in the lab, is lead author on the preprint. Congratulations, all!
The Cohen Lab has a new preprint, “Modular effects of gene promoters and chromatin environments on noise in gene expression.” Siqi Zhao, a graduate student in the lab, is lead author on the preprint. Congratulations, all!
The Dougherty Lab has a new preprint, “A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.” Tomás Lagunas Jr, a graduate student in the lab, is lead author on the...
The Wang Lab published a paper in Communications Biology, “Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis.” Jennifer Flynn, a graduate student in the lab, is lead...
The Morris Lab contributed to a paper in Stem Cell Reports, “Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids.” Congratulations, all!
Dr. Jeff Milbrandt, MD, PhD, James S. McDonnell Professor, head of the Department of Genetics, and executive director of the McDonnell Genome Institute at Washington University School of Medicine, and Dr. Aaron DiAntonio, the Alan A. and Edith L. Wolff Professor of...
The Jin Lab collaborated on a paper published in Neurology Genetics, “Recessive COL4A2 Mutation Leads to Intellectual Disability, Epilepsy, and Spastic Cerebral Palsy.” Congratulations, all!
The Jin Lab collaborated on a paper published in Clinical Genetics, “Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.” Congratulations, all!
The Wang Lab contributed to a new paper published in Developmental Cell, “Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.” Congratulations, all!
The Mitra Lab has a new preprint, “Measuring Transcription Factor Binding and Gene Expression using Barcoded Self-Reporting Transposon Calling Cards and Transcriptomes.” Matt Lalli, a former postdoc in the Mitra Lab, is lead author on the preprint....
The Mitra Lab collaborated with the Rubin Lab and others on a paper published in PNAS, “Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma.” Congratulations, all!
The Division of Statistical Genomics (DSG) published a paper in Circulation: Genomic and Precision Medicine, “Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-onset in Three Different CHD Family-based Ascertainments.”...
The Dougherty Lab has a new preprint, “Functional connectivity of the developing mouse cortex.” Rachel Rahn, a graduate student in the lab, is lead author. Congratulations, all!
The Dougherty Lab has a new preprint, “Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model.” Kayla Nygaard, a graduate student in the lab, is lead author on the preprint. Congratulations, all!
The Dougherty Lab has a new paper published in the Journal of Neurodevelopmental Disorders, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint....
The Buchser Lab has a new preprint, “Mitochondrial Phenotypes Distinguish Pathogenic MFN2 Mutations by Pooled Functional Genomics Screen.” Lead authors include Alex Yenkin, a research technician in the lab, and Jack Bramley, a staff scientist in the lab....
The Cohen Lab has a new preprint, “Genomic environments scale the activities of diverse core promoters.” Authors include graduate student Clarice Hong and Barak Cohen, PhD, Professor of Genetics and the Alvin Goldfarb Distinguished Professor of...
The Jin Lab published a paper in Star Protocols, “Analysis workflow to assess de novo genetic variants from human whole-exome sequencing.” Grad students Spencer King and Sam Peters are authors. Sheng Chih (Peter) Jin, PhD, Assistant Professor of Genetics...
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint. David Gutmann, MD, PhD, Director, Washington...
The Dougherty Lab published a paper in Nature Communications, “Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.” Lead author is Kristina Sakers, PhD, a former graduate student in the...
The Dougherty Lab has a new preprint, “Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays.” Bernie Mulvey, a grad student in the lab, is first author. Joe Dougherty, PhD, Associate...
The Lawson Lab recently published a review in the American Journal of Physiology-Endocrinology and Metabolism, “Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.” Alex Miranda, a grad student in the Lawson Lab, is...
The Dougherty Lab contributed to a new paper published in Science Advances, “Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.” Andrew Luskin, a former graduate student in the Department of Anesthesiology at Washington...
Dr. Sheng Chih (Peter) Jin was awarded funding from Washington University Institute of Clinical and Translational Sciences (ICTS) as part of the 14th annual Clinical and Translational Research Funding Program (CTRFP). Dr. Jin was one of seventeen researchers who was...
The Morris Lab contributed to a new paper published in Developmental Cell, “Localized EMT reprograms glial progenitors to promote spinal cord repair.” Dana Klatt Shaw, PhD, a postdoc in the Mokalled Lab at Washington University School of Medicine, is lead...
James Allen, PhD, a former graduate student in the labs of Dr. Jim Skeath, Professor of Genetics at Washington University School of Medicine, and the late Dr. Stephen Johnson, Professor of Genetics at Washington University School of Medicine, was recently named an...
The Dougherty Lab has a new paper in Behavioral Neuroscience, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, Assistant Professor of Pediatrics at...
The Buchser Lab collaborated with the Guilak Lab on a paper published in The FASEB Journal, “Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity.” Natalia S....
The Genome Engineering and iPSC Center (GEiC) and the Milbrandt and DiAntonio Labs at Washington University School of Medicine collaborated on a paper published in Experimental Neurology, “SARM1 is required in human derived sensory neurons for injury-induced and...
The Cohen Lab has a new preprint, “Information Content Differentiates Enhancers From Silencers in Mouse Photoreceptors.” Ryan Friedman, a graduate student in the lab, is lead author on the preprint. Barak Cohen, PhD, Professor of Genetics and the Alvin...
The Pincus Lab published a paper in eLife, “Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans.” Holly Kinser, a former grad student in the lab, is lead author on the paper. Zach Pincus, PhD, Assistant...
The Milbrandt Lab collaborated on a paper with the Wu Lab from Harvard Medical School and the DiAntonio Lab at Washington University School of Medicine, “Multiple domain interfaces mediate SARM1 autoinhibition.” Chen Shen, a postdoc in the Wu Lab, is lead...
Susan Dutcher, PhD, Professor of Genetics at Washington University School of Medicine, was co-chair of the Special Interest Subgroup on centrioles, basal bodies and centrosomes, at the virtual American Society of Cell Biology. Congratulations, Dr. Dutcher!
The Dutcher Lab collaborated on a paper published recently in Nature Structural & Molecular Biology, “Structures of radial spokes and associated complexes important for ciliary motility.” The article made the cover of the publication. Researchers...
Mike Rieger, a former grad student in the Dougherty Lab, had a paper published in Cell Reports, “CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3′ UTR Elements.” Members...
Mike Vasek, a postdoc in the Dougherty Lab, has a new preprint, “Microglia perform local protein synthesis at perisynaptic and phagocytic structures.” Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of...
Tychele Turner, PhD, Assistant Professor of Genetics at Washington University School of Medicine, is co-corresponding author on a paper in Scientific Reports, “Thousands of high-quality sequencing samples fail to show meaningful correlation between 5S and 45S...
Samantha Morris, PhD, Assistant Professor of Genetics and Developmental Biology at Washington University School of Medicine, recently collaborated on a perspective piece published in Cell Stem Cell, “Computational Stem Cell Biology: Open Questions and Guiding...
Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of Medicine, won Best Mentor of the Year at the WashU 2020 Neuroscience Awards. Congratulations, Dr. Dougherty!
Jason Yi, Assistant Professor of Neuroscience at Washington University School of Medicine, and Susan Maloney, PhD, Assistant Professor of Psychiatry at Washington University School of Medicine and a member of the Dougherty Lab in the Department of Genetics, are...
The Wang Lab published a paper in Genome Research, “Epigenomic differences in the human and chimpanzee genomes are associated with structural variation.” Xiaoyu Zhuo, a postdoc in the lab, is leader author on the paper. Ting Wang, PhD, Professor of...
The Wang Lab published a paper in Genome Research, “Transcript assembly improves expression quantification of transposable elements in single-cell RNA-seq data.” Wanqing Shao, a postdoc in the lab, is lead author on the paper. Ting Wang, PhD, Professor of...
The Stormo Lab published a paper in Communications Biology, “Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation.” The lab used the yeast GFP collection as a rapid screen for genes exhibiting feedback...
The Dougherty Lab has a new preprint, “A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.” The preprint shares the lab’s work on the MYT1L gene and its...
The Mollah Lab has a new preprint, “A Non-Negative Tensor Factorization Approach to Deconvolute Microenvironment in Breast Cancer.” Min Shi, a postdoc in the lab, is senior author on the preprint. Liubou Klindziuk, a summer intern in the lab, is also an...
The Dougherty Lab contributed to a paper by the Gabel Lab in Cell Reports, “DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.” Diana Christian and Dennis Wu, graduate...
Researchers at Washington University School of Medicine in St. Louis received a two-year, $5 million grant to offer 50,000 saliva tests for the SARS-CoV-2 virus developed by researchers at the medical school to students, teachers and staff in the six special education...
The Dougherty Lab published a review in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.” Bernie Mulvey and Tomás Lagunas Jr., graduate students in the lab, are lead...
The Wang Lab contributed to a new paper in Nature, “A map of cis-regulatory elements and 3D genome structures in zebrafish.” Senior authors include Feng Yue, PhD, Director, Institute for Augmented Intelligence in Medicine – Center for Advanced...
Sheng Chih (Peter) Jin, PhD, assistant professor of genetics at Washington University School of Medicine, and colleagues were recently awarded $3.2M by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (NIH)...
The Wang Lab contributed to a new paper in Cell Reports, “Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors.” Postdoc Hyung Joo Lee is an author, as well as staff scientist Xiaoyun Xing. Ting...
The Morris Lab and the Solnica-Krezel Lab published a new paper in eLife, “High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures.” Kyaw Thu Minn, a graduate student in the Solnica-Krezel Lab,...
The Morris Lab has a new review published in Developmental Cell, “Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development.” It discusses the history of these disciplines and how single-cell genomic technologies are enabling the...
Sheng Chih (Peter) Jin, PhD, Assistant Professor of Genetics at Washington University School of Medicine, recently contributed to a new paper in JAMA Pediatrics, “Exome Sequencing as a Potential Diagnostic Adjunct in Sporadic Congenital Hydrocephalus.”...
The Mitra Lab contributed to a new preprint, “Brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma.” Najla Kfoury-Beaumont, PhD, a faculty research scientist at UCSD, is first author on the preprint. Robi Mitra, PhD, Professor...
The Dougherty Lab has a new preprint, “Identification of compounds enhancing Aqp4 stop codon readthrough.” Darshan Sapkota, a postdoc in the lab, is lead author. Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University...
The Lawson Lab recently published a paper in Physiological Reports, “Spontaneous restoration of functional β‐cell mass in obese SM/J mice.” Alex Miranda, a graduate student in the lab, is lead author on the paper. Heather Lawson, PhD, Assistant Professor...
The Milbrandt and DiAntonio Labs have a new paper in eLife, “SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.” Yo Sasaki, PhD, Associate Professor in the Department of Genetics at Washington University School of...
Susan Dutcher, PhD, Professor of Genetics, Cell Biology and Physiology at Washington University School of Medicine, has published a new preview in Developmental Cell, “Basal Feet: Walking to the Discovery of a Novel Hybrid Cilium.” Dr. Dutcher co-authored...
Tomás Lagunas Jr, a graduate student in the Dougherty Lab, recently won the student presentation award in Genetics at the SACNAS 2020 conference. The SACNAS organization is “dedicated to fostering the success of Chicanos/Hispanics and Native Americans, from...
The Buchser Lab has a new preprint, “Low-Cost Manually Assembled Open Source Reader for Isothermal Pathogen Detection from Saliva using RT-LAMP: SARS-CoV-2 Use Case.” Jack Bramley, a staff scientist in the lab, is lead author on the preprint. Senior...
Samantha Morris, PhD, Assistant Professor of Genetics and Developmental Biology at Washington University School of Medicine in St. Louis, was recently named a 2020 NYSCF-Roberston Investigator. The NYSCF Investigator Program encourages promising early career...
The Jin Lab recently had a paper published in Nature Medicine, “Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.” Sheng Chih (Peter) Jin, PhD, Assistant Professor in the Department of...
The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor of...
Eli Lilly & Company recently acquired Disarm Therapeutics, a pre-clinical NAD-boosting company treating neuropathy and neurodegenerative diseases, for $135 million and a potential additional $1.2 billion in milestones. Disarm was founded by Atlas Venture; Jeff...
The Wang Lab recently collaborated on a paper in Nature, “Cell-type-specific 3D epigenomes in the developing human cortex.” Senior authors include Dr. Yin Shen from the University of California, San Francisco; Dr. Arnold Kriegstein from the University of...
Jeffrey R. Milbrandt, MD, PhD, the James S. McDonnell Professor and head of the Department of Genetics at Washington University School of Medicine, and Robi Mitra, PhD, the Alvin Goldfarb Professor of Computational Biology and a professor of genetics at Washington...
The Lawson Lab published a paper recently in Cell Reports, “Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice.” Caryn Carson, a graduate student in the lab who recently earned her PhD, is lead author on the paper. Heather...
The Dougherty Lab has a new preprint, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, a collaborating researcher in the lab and a a neonatologist at...
The Wang Lab published a paper recently in Genome Biology, “Tissue-specific usage of transposable element-derived promoters in mouse development.” Benpeng Miao, a postdoc in the Wang Lab, is lead author on the paper. Ting Wang, PhD, Professor of Genetics...
Simona Sarafinovska, a graduate student in the Dougherty Lab, received an abstract award for the International Society for Developmental Psychobiology (ISDP) 2020 conference to give an oral presentation on the lab’s findings on “Effects of Ontogenetic Oxycodone...
The Jin Lab recently had a paper published in Nature Genetics, “Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.” Sheng Chih (Peter) Jin, PhD, assistant professor of genetics at Washington University School of Medicine, is lead...
The Mitra Lab recently had a paper accepted in Bioinformatics, “The qBED track: a novel genome browser visualization for point processes.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author. The Wang Lab contributed to the paper. Ting...
Heather Lawson, PhD, Assistant Professor in the Department of Genetics at Washington University School of Medicine, and Mike Provence, PhD, Professor of Genetics and Director of the Division of Statistical Genetics (DSG) at Washington University School of Medicine,...
The Mitra and Milbrandt Labs had a paper published recently in Genome Research, “High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation.” Matt Lalli,...
The Jin Lab published a paper in iScience, “Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia.” Sheng Chih (Peter) Jin, PhD, Assistant Professor in the Department of Genetics at Washington University...
Tomás Lagunas Jr., a graduate student in the Dougherty Lab, recently won the Early Career Investigator Program award from World Congress of Psychiatric Genetics. He will be attending both WCPG 2020 virtually and WCPG 2021 in Montreal. Congratulations, Tomás!
The Wang Lab recently published a paper, “Exploring the coronavirus pandemic with the WashU Virus Genome Browser,” in Nature Genetics. Jennifer Flynn, a graduate student in the lab, is lead author on the paper. Ting Wang, PhD, Professor of Genetics and The...
The Morris Lab recently had a paper published, “Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth.” The paper is published in Cell Stem Cell and done in collaboration with...
The Turner Lab has a new preprint, “De Novo Mutation in an Enhancer of EBF3 in simplex autism.” Evin Padhi, a graduate student in the lab, is first author on the preprint. Tychele Turner, PhD, Assistant Professor in the Department of Genetics at Washington...
The Department of Genetics and McDonnell Genome Institute (MGI) at Washington University School of Medicine, in collaboration with biotech company Fluidigm, are developing a saliva test to detect the SARS-CoV-2 virus. Fluidigm this week received emergency use...
Matt Lalli, a postdoc in the Mitra and Milbrandt Labs, recently accepted a position as Instructor in the Department of Psychiatry, Division of Seaver Autism Center for Research and Treatment, at Icahn School of Medicine at Mount Sinai. Congratulations, Matt! Best of...
The Mitra Lab recently had a paper accepted in Genome Research, “High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.” Matt Lalli, a postdoc in...
The Wang Lab’s WashU Virus Genome Browser manuscript, “Exploring the coronavirus pandemic using the WashU Virus Genome Browser,” was accepted for publication in Nature Genetics. Congratulations, all! Read more about the WashU Virus Genome Browser...
