Yung-Chun (David) Wang, PhD, an instructor in the Jin lab was recently awarded the Center of Regenerative Medicine’s hCTO microgrant. This microgrant will support his research into congenital hydrocephalus (CH), a developmental brain disorder characterized by abnormal cerebrospinal fluid accumulation. Specifically, the grant will enable the team to validate putative pathogenic homozygous variant identified in a CH patient with uniparental isodisomy of chromosome 8. Using patient-derived induced pluripotent stem cells (iPSCs), the lab aim to generate neural progenitor cells (NPCs) and investigate the functional impact of the mutation.