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Emma Farley, PhD
Assistant Professor
Department of Medicine
University of California-San Diego

October 13 @ 12:00 pm - 1:00 pm

presents, “Affinity optimizing enhancer variants disrupt development”

Hosted by: Dr. Barak Cohen
In-person only:  Connor Auditorium (FLTC)

Talk abstract:  An emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression during development. Here we discover that affinity optimizing single-nucleotide variants can violate this principle, disrupt tissue-specific gene expression, and alter phenotypes in Ciona, mice, and humans.

Details

Date:
October 13
Time:
12:00 pm - 1:00 pm
Event Category:

Organizer

Barak Cohen
Email:
cohen@genetics.wustl.edu
Website:
http://genetics.wustl.edu/bclab