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Emma Farley, PhD
Department of Medicine
University of California-San Diego
October 13 @ 12:00 pm - 1:00 pm
presents, “Affinity optimizing enhancer variants disrupt development”
Hosted by: Dr. Barak Cohen
In-person only: Connor Auditorium (FLTC)
Talk abstract: An emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression during development. Here we discover that affinity optimizing single-nucleotide variants can violate this principle, disrupt tissue-specific gene expression, and alter phenotypes in Ciona, mice, and humans.