presents, “May you live a full life for 100 years, plus one more to repent!  The Long Life Family Study”

Hybrid:  Connor Auditorium (FLTC) or via Zoom webinar: https://wustl-hipaa.zoom.us/j/94367220300

Hosted by: Dr. Joe Dougherty
Seminar abstract: The Long Life Family Study is a multinational, multicenter, longitudinal, observational study of ~5,000 participants in ~500 pedigrees selected for high rates of extreme longevity.  Fewer than 1% of the Framingham Heart Study pedigrees would qualify for LLFS.  On average, this cohort shows remarkable protection from most of the diseases of aging, but not uniformly so.  And there are a few interesting surprises and paradoxes.  There is considerable phenotypic and genotypic heterogeneity, suggesting there is no one “secret” to healthy aging and longevity, but rather many “roads to Rome.”  There is strong evidence of novel rare protective genetic variants running in selected pedigrees, and we are currently using massive Big Data “OMICs” approaches to facilitate genetic mapping and elucidate mechanisms of action.