This seminar has been cancelled.

presents, "Genetic and environmental determinants of DNA methylation in diverse human tissue types" Hosted by: Dr. Nancy Saccone In-person only:  Connor Auditorium (FLTC) Talk abstract: Tissue-specific characterization of variability in DNA methylation (DNAm) is needed to understand its role in gene regulation and its relevance to complex traits. We generated array-based DNAm profiles for ~1000 human samples from the Genotype-Tissue Expression (GTEx) project, representing 9 tissue types.  This talk will highlight (1) the contribution of inherited genetic variation and tobacco…

presents, "Affinity optimizing enhancer variants disrupt development" Hosted by: Dr. Barak Cohen In-person only:  Connor Auditorium (FLTC) Talk abstract:  An emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression during development. Here we discover that affinity optimizing single-nucleotide variants can violate this principle, disrupt tissue-specific gene expression, and alter phenotypes in Ciona, mice, and humans.

presents, "Publishing for impact" Hosted by: Dr. Ting Wang In-person only:  Connor Auditorium (FLTC) Talk abstract:  In this talk, I will share tips on the publishing process, what journals look for, and how to productively interact with editors. I will also look forward to answering any questions related to academic publishing.

presents, "Protein interaction profiling of centrosomes in normal and disease states" Talk abstract:  The centrosome is the major microtubule-organizing center (MTOC) in animal cells. Centrosomes control a plethora of cellular processes including the organization of the interphase microtubule network, the assembly of the mitotic spindle and the formation of cilia/flagella. Mitotic cell division relies on the formation of a robust bipolar spindle, which mediates the accurate segregation of genetic material to daughter cells. In mitosis, two centrosomes need to be…

presents, "A multi-omics cell atlas for human healthy and disease kidney" Hosted by:  Dr. Shamim Mollah In-person only:  Connor Auditorium (FLTC) Talk abstract:  Detailed characterization of the cell types comprising the highly complex human organs is essential to understanding their functions. Such tasks require highly scalable experimental approaches to examine multiple aspects of the molecular state of individual cells, registering cells to 3D coordinates, as well as the computational integration to produce unified cell state annotations and interpretation with biological…

presents, "What are my cells? A journey into cell identity and new genomic technologies" Hosted by: Dr. Joe Dougherty In-person only:  Connor Auditorium (FLTC) Talk abstract:  A mechanistic understanding of how cell identity is established and maintained is fundamental to the precise engineering of cell fate. Here, I will present new genomic technologies developed by my lab to permit single-cell lineage tracing throughout reprogramming, accompanied by recording of TF-binding and chromatin accessibility profiling. Integrating this information using our unique computational tools for interrogating gene regulatory networks…

presents, 'Cancer Epigenetics’: what is in a name? Talk abstract:  Cancer epigenetic studies to date have largely focused on the impact of heritable non-genetic molecular alternations on gene function – inactivating tumor suppressor genes or activating oncogenes, much akin to genetic mutations. However, despite the widely used modern operative definition of the word ‘epigenetics’ – as a description of various modifications to the chromatin,  the concept of ‘epigenetics’ was originally used to describe cellular characteristics.  Using cancers arising from the female…