presents, “Genetic influences on human cortical development and structure” Hosted by: Dr. Joseph Dougherty

presents, "Cardioinformatics approaches for drug discovery"

presents, "Astrocyte and oligodendrocyte biology in development and disease: lessons from humans and mice" Hosted by: Dr. Tristan Li

presents, "Striatal glia differentially contribute to Aβ pathology, tauopathy, and neurodegeneration" Hosted by: Dr. Joe Dougherty Seminar abstract:  We performed the first single-nucleus transcriptome comparison of control, AD, and PD striata. We identified three astrocyte subpopulations and two microglia subpopulations conserved across different brain regions such as entorhinal cortex and prefrontal cortex, and between humans and mice.  We reveal commonalities and differences between AD and PD glia and regional differences in their contributions toward amyloid pathology, tauopathy, and neurodegeneration.

presents, "Tackling human gene function in model organisms" Hosted by: Dr. Tim Schedl Seminar abstract:  It is estimated that there are more than 300 million patients worldwide with a rare genetic disease. Many of these patients remain undiagnosed for many years. By sequencing their genomes and those of their relatives, human geneticists can now discover genetic variations that are rare or ultra-rare. However, considering that there are many polymorphisms in the population, assessing which variant(s) is/are related to the observed…

presents, "Large-scale approaches to classify and understand genetic variants" hosted by: Dr. Barak Cohen

Hybrid:  Connor Auditorium (FLTC), Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300 presents, "Quantitative proteomics for understanding epigenetic cancer mechanisms" hosted by: Dr. Susan Dutcher Seminar abstract: Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing.  Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations.…

presents, "Exploring the Genetics of Neurodevelopmental Psychiatric Disorders in a Health Care System" Hosted by: Dr. Tychele Turner Seminar abstract: Autism, schizophrenia, and other clinically distinct neurodevelopmental psychiatric disorders (NPD) have shared genetic etiologies, including copy number variants (CNVs) and single gene disorders. To date, rare variants that cause NPD have primarily been investigated in clinically-ascertained cohorts, therefore population-based estimates of their prevalence and penetrance are lacking. In this presentation, the prevalence, penetrance, and personal utility of NPD CNVs and…

presents, "Deciphering Enhancer Function In Vivo" Hosted by: Dr. Tychele Turner Seminar abstract:  Transcriptional enhancers are a predominant class of non-coding functional DNA elements that control when and where genes are expressed. We use innovative mouse genome engineering and genomics techniques to address two questions about enhancer biology: 1. How do mutations in enhancers lead to human congenital disorders? and 2. How do enhancers relay regulatory information to their target genes over long genomic distances?

presents, "May you live a full life for 100 years, plus one more to repent!  The Long Life Family Study" Hybrid:  Connor Auditorium (FLTC) or via Zoom webinar: https://wustl-hipaa.zoom.us/j/94367220300 Hosted by: Dr. Joe Dougherty Seminar abstract: The Long Life Family Study is a multinational, multicenter, longitudinal, observational study of ~5,000 participants in ~500 pedigrees selected for high rates of extreme longevity.  Fewer than 1% of the Framingham Heart Study pedigrees would qualify for LLFS.  On average, this cohort shows remarkable…

presents, "The role of noncoding RNAs in cancer: shedding light on the transcriptomic dark matter" Hosted by: Dr. Shamim Mollah HYBRID Zoom attendee webinar link:https://wustl-hipaa.zoom.us/j/94367220300 In-person:  Couch Building, 6001B Seminar abstract: Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing, and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). While eRNAs have become…

presents, "How cilia signal" Hybrid Zoom attendee webinar link:  https://wustl-hipaa.zoom.us/j/94367220300 In-person: Connor Auditorium, FLTC hosted by:  Drs. Susan Dutcher and Moe Mahjoub

presents, “RNA Editing and Innate Immunity” Hosted by: Dr. Rob Mitra Hybrid Zoom attendee webinar link: https://wustl-hipaa.zoom.us/j/94367220300 In-person:  Couch 6001B Seminar abstract:  To avoid aberrant innate immunity, endogenous double-stranded RNA (dsRNA) must be edited by ADAR1, suppressing cytosolic MDA5-mediated dsRNA sensing. Mice without RNA editing by ADAR1 are embryonic lethal, but live to full life span upon MDA5 removal. In humans, ADAR1 loss-of-function and MDA5 gain-of-function mutations lead to rare autoimmune diseases. In this talk, I will discuss our recent…

presents, "Modeling late-onset human neurodegeneration by neuronal reprogramming" Hosted by: Dr. Joseph Dougherty HYBRID In-person: Couch, 6001B Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300

presents, "Title TBD" Hosted by:  Dr. Joe Dougherty