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UID:20241210T1520Z-1733844002.3806-EO-3708-1@10.73.10.188
STATUS:CONFIRMED
DTSTAMP:20260415T001645Z
CREATED:20241210T144610Z
LAST-MODIFIED:20260203T145127Z
DTSTART;TZID=America/Chicago:20260205T120000
DTEND;TZID=America/Chicago:20260205T130000
SUMMARY: Genetics Seminar Series – Benjamin A. Garcia\, PhD
DESCRIPTION: Benjamin A. Garcia\, PhD Raymond H. Wittcoff Distinguished Pro
 fessor and Head\, Department of Biochemistry and Molecular Biophysics\, Was
 hU Medicine Host: Dr. Lijuan Feng Abstract: Histones are small proteins tha
 t package DNA into chromosomes\, and a large number of studies have showed 
 that several post-translational modification (PTM) sites on the histones ar
 e associated with both gene […]
X-ALT-DESC;FMTTYPE=text/html: <h3>Benjamin A. Garcia\, PhD</h3><p>Raymond H
 . Wittcoff Distinguished Professor and Head\,</p><p>Department of Biochemis
 try and Molecular Biophysics\,</p><p>WashU Medicine</p><p><strong>Host: Dr.
  Lijuan Feng</strong></p><p><strong>Abstract:</strong> Histones are small p
 roteins that package DNA into chromosomes\, and a large number of studies h
 ave showed that several post-translational modification (PTM) sites on the 
 histones are associated with both gene activation and silencing.  Along wit
 h DNA and small non-coding RNA\, histone PTMs make up epigenetic mechanisms
  that control gene expression patterns outside of DNA sequence mutations. D
 ysregulation of these chromatin networks underlie several human diseases su
 ch as cancer. Here I will give an update on technology advancements that ha
 ve allowed for high-throughput quantitative mass spectrometry analyses of h
 istone PTMs and chromatin structure\, and how we are applying these methods
  to understand epigenetic reprogramming found in malignant peripheral nerve
  sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss
  of function alterations in polycomb-repressive complex 2 (PRC2)\, a histon
 e-modifying complex involved in transcriptional silencing.</p><p><img class
 ="alignnone wp-image-4663 size-full" src="https://genetics.wustl.edu/app/up
 loads/2024/12/1-18.png" alt="" width="1545" height="2000" /> <img class="al
 ignnone wp-image-4664 size-full" src="https://genetics.wustl.edu/app/upload
 s/2024/12/2-17.png" alt="" width="1545" height="2000" /></p>
CATEGORIES:Spring 2026
LOCATION:Connor Auditorium
GEO:38.635470;-90.262723
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/garciab-2026/
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DTSTART:20251102T070000
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