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UID:20240513T1949Z-1715629742.6612-EO-3086-1@10.73.2.159
STATUS:CONFIRMED
DTSTAMP:20260415T204910Z
CREATED:20240513T171611Z
LAST-MODIFIED:20240924T180334Z
DTSTART;TZID=America/Chicago:20241003T120000
DTEND;TZID=America/Chicago:20241003T130000
SUMMARY: Stormo Lecture: Michael Brent\, PhD
DESCRIPTION: Michael Brent\, PhD\, Henry Edwin Sever Professor of Engineeri
 ng\, Washington University School of Medicine\, Department of Computer Scie
 nce and Engineering Presents: Mapping and modeling transcriptional regulato
 ry networks Host: Dr. Guoyan Zhao In person only: Connor Auditorium Abstrac
 t: Transcription factor (TF) binding locations can be mapped using methods 
 such as ChIP-Seq or Calling Cards and the functional targets […]
X-ALT-DESC;FMTTYPE=text/html: <h5><a href="http://mblab.wustl.edu/">Michael
  Brent\, PhD\,</a> Henry Edwin Sever Professor of Engineering\, Washington 
 University School of Medicine\, Department of Computer Science and Engineer
 ing</h5><p>Presents: <em>Mapping and modeling transcriptional regulatory ne
 tworks</em></p><p>Host: Dr. Guoyan Zhao</p><p>In person only: Connor Audito
 rium</p><p>Abstract: Transcription factor (TF) binding locations can be map
 ped using methods such as ChIP-Seq or Calling Cards and the functional targ
 ets of a TF can be identified by perturbing the TF and measuring changes in
  gene expression. However\, it has long been known\, across many organisms 
 and datasets\, that the agreement between binding locations and perturbatio
 n responses is extremely poor. Indeed\, most binding events appear to be no
 n-functional. Identifying the direct\, functional targets of TFs is essenti
 al for understanding how DNA sequence gives rise to phenotypes. In this tal
 k\, I will present an integrated analysis of multiple datasets\, including 
 new Calling Cards data\, to shed light on this discrepancy and propose stra
 tegies for predicting perturbation responses from TF binding locations.</p>
 <p>Livestream link: https://wustl-hipaa.zoom.us/j/92134502449</p><p><img cl
 ass="alignnone wp-image-3381 size-full" src="https://genetics.wustl.edu/app
 /uploads/2024/05/1-3.png" alt="" width="1545" height="2000" /> <img class="
 alignnone wp-image-3382 size-full" src="https://genetics.wustl.edu/app/uplo
 ads/2024/05/2-2.png" alt="" width="1545" height="2000" /></p>
CATEGORIES:Fall 2024
LOCATION:Connor Auditorium (FLTC)
GEO:0;0
ORGANIZER;CN="e.gan":MAILTO:e.gan@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/genetics-seminar-4/
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DTSTART:20240310T080000
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