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UID:20260217T2100Z-1771362054.8833-EO-4723-1@10.73.8.232
STATUS:CONFIRMED
DTSTAMP:20261002T142632Z
CREATED:20260217T193655Z
LAST-MODIFIED:20260925T204115Z
DTSTART;TZID=America/Chicago:20261001T120000
DTEND;TZID=America/Chicago:20261001T130000
SUMMARY: Genetics Seminar – Precision Medicine Pathways Keynote Lecture – P
 eter Jones\, Ph.D.\, D.Sc. (hon)
DESCRIPTION: Peter Jones\, Ph.D.\, D.Sc. (hon) Distinguished Professor Depa
 rtment of Epigenetics Van Andel Institute Talk title: Targeting TET2 and In
 tercepting Myeloid Cancers with Vitamin C Abstract: Mutations in genes whic
 h apply and remove DNA cytosine methylation\, such as DNMT3A and TET2 are c
 ommon in myeloid malignancies and precursor conditions such as clonal cytop
 enia of undetermined significance […]
X-ALT-DESC;FMTTYPE=text/html: <h3><a href="https://joneslab.vai.org/">Peter
  Jones\, Ph.D.\, D.Sc. (hon)</a></h3><p>Distinguished Professor</p><p>Depar
 tment of Epigenetics</p><p>Van Andel Institute</p><p>Talk title: <em>Target
 ing TET2 and Intercepting Myeloid Cancers with Vitamin C</em></p><p>Abstrac
 t: Mutations in genes which apply and remove DNA cytosine methylation\, suc
 h as DNMT3A and TET2 are common in myeloid malignancies and precursor condi
 tions such as clonal cytopenia of undetermined significance (CCUS). Cytosin
 e methylation\, in addition to having created CpG islands over evolution\, 
 plays a substantial role in the reversible control of enhancers\, catalyzed
  by DNMT3A and TET2 respectively. Vitamin C is essential for TET2 activity\
 , and our phase 2 randomized clinical trial shows that oral vitamin C may p
 rolong the overall survival of CCUS patients with wild type\, but not mutat
 ed TET2.</p><p>Host: Dr. Tim Schedl</p><p><img class="aligncenter wp-image-
 5171 size-full" src="https://genetics.wustl.edu/app/uploads/2026/02/Flyer-P
 eterJones.png" alt="" width="1582" height="2110" /></p><p> </p>
CATEGORIES:Fall 2026
LOCATION:Connor Auditorium (FLTC)
GEO:0;0
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/genetics-seminar-prec
 ision-medicine-pathways-keynote-lecture/
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DTSTART:20260308T080000
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