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UID:20241210T1520Z-1733844002.3873-EO-3709-1@10.73.10.188
STATUS:CONFIRMED
DTSTAMP:20260416T170414Z
CREATED:20241210T144631Z
LAST-MODIFIED:20260131T173953Z
DTSTART;TZID=America/Chicago:20260212T120000
DTEND;TZID=America/Chicago:20260212T130000
SUMMARY: Genetics Seminar Series – Wanlu Liu\, PhD
DESCRIPTION: Wanlu Liu\, PhD Visiting Scholar\, Stanford University\, Schoo
 l of Medicine Associate Professor\, Vice Dean\, Zhejiang University Talk ti
 tle: Exploring Human T cells and TCRαβ repertoire at the single-cell level:
  Phenotypic Heterogeneity and Disease Associations Abstract: T cells repres
 ent a dynamic record of a host’s immunological history\, where cellular ide
 ntity and antigen recognition are intrinsically linked. In this talk\, […]
X-ALT-DESC;FMTTYPE=text/html: <h4>Wanlu Liu\, PhD</h4><p class="p1"><i>Visi
 ting Scholar\, </i><i>Stanford University\, School of Medicine</i></p><p cl
 ass="p1"><i>Associate Professor\, Vice Dean\, </i><i>Zhejiang University</i
 ></p><p><strong>Talk title:</strong> <em><span role="presentation"><b>Explo
 ring Human T cells and TCRαβ repertoire at the single-cell level</b></span>
 <span role="presentation"><b>: </b></span><span role="presentation">Phenoty
 pic Heterogeneity and Disease Associations</span></em></p><p><strong>Abstra
 ct:</strong> T cells represent a dynamic record of a host's immunological h
 istory\, where cellular identity and antigen recognition are intrinsically 
 linked. In this talk\, I will tell two stories regarding the large scale in
 tegration and analysis of single cell multi omics data. First\, I will desc
 ribe the development of scAtlasVAE\, a framework that enabled us to build a
  comprehensive human CD8 T cell atlas across 68 studies\, uncovering conser
 ved phenotypic transitions in cancer and inflammation. Second\, I will intr
 oduce TCR-DeepInsight\, a transformer based model that jointly represents T
  cell receptor sequences and gene expression to identify disease associated
  clonotypes at a population level. Together\, these methods provide a roadm
 ap for decoding the rules of immune recognition and cellular fate in human 
 disease.</p><p><strong>Host:</strong> Dr. Ting Wang</p><p><img class="align
 center wp-image-4637 size-full" src="https://genetics.wustl.edu/app/uploads
 /2024/12/1-17.png" alt="" width="1545" height="2000" /> <img class="alignno
 ne wp-image-4638 size-full" src="https://genetics.wustl.edu/app/uploads/202
 4/12/2-16.png" alt="" width="1545" height="2000" /></p>
CATEGORIES:Spring 2026
LOCATION:Connor Auditorium
GEO:38.635470;-90.262723
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/liu-wanlu-2026/
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TZOFFSETTO:-0600
DTSTART:20251102T070000
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