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UID:20231011T2245Z-1697064323.9343-EO-102-1@10.73.2.159
STATUS:CONFIRMED
DTSTAMP:20260507T144109Z
CREATED:20230622T182830Z
LAST-MODIFIED:20231005T214809Z
DTSTART;TZID=America/Chicago:20230914T120000
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SUMMARY: Mike Gandal\, MD\, PhD
DESCRIPTION: Mike Gandal\, MD\, PhD Hetznecker Associate Professor of Psych
 iatry Department of Psychiatry Perelman School of Medicine University of Pe
 nnsylvania presents\, “Isoform regulation in the developing human brain inf
 orms mechanisms of neuropsychiatric disorders” Hosted by:  Dr. Joe Doughert
 y In-person only:  Connor Auditorium (FLTC) Talk abstract:  Large-scale gen
 etic studies have now identified hundreds of common and rare […]
X-ALT-DESC;FMTTYPE=text/html: <p>Mike Gandal\, MD\, PhD Hetznecker Associat
 e Professor of Psychiatry Department of Psychiatry Perelman School of Medic
 ine University of Pennsylvania</p><p>presents\, “Isoform regulation in the 
 developing human brain informs mechanisms of neuropsychiatric disorders”<br
  />Hosted by:  Dr. Joe Dougherty<br />In-person only:  Connor Auditorium (F
 LTC)<br />Talk abstract:  Large-scale genetic studies have now identified h
 undreds of common and rare variants associated with neurodevelopmental and 
 psychiatric disorders. However\, interpretation of the biological functiona
 l impact and pathogenicity of these variants remains a critical obstacle hi
 ndering clinical translation. To address this challenge\, we have developed
  a large-scale functional genomic atlas of human brain development\, integr
 ating genotype and RNA-sequencing based gene expression measures in >650 de
 veloping human brains. In parallel\, we have performed high depth long-read
  sequencing in a subset of samples to capture the full complexity of altern
 ative splicing and isoform diversity. Leveraging this resource has enabled 
 prioritization of previously hidden candidate molecular mechanisms underlyi
 ng genetic risk for autism spectrum disorders and schizophrenia\, with a su
 bstantial fraction acting through dysregulation of alternative splicing.</p
 >
CATEGORIES:Fall 2023
LOCATION:Connor Auditorium (FLTC)
GEO:0;0
ORGANIZER;CN="bmarston":MAILTO:bmarston@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/mike-gandal-md-phdhet
 znecker-associate-professor-of-psychiatrydepartment-of-psychiatryperelman-s
 chool-of-medicineuniversity-of-pennsylvania/
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