Mike Love\, PhD Associate Professor Depart ments of Genetics & Biostatistics University of North Carolina\, Chapel Hil l
presents\, “Assaying effects of GWAS variants in organs with in viv
o massively parallel reporter assay (MPRA)”
Hosted by: Dr. Heather La
wson
In-person only: Connor Auditorium (FLTC)
Abstract:
I will present an approach to connect cis regulation of gene expressi on in relevant tissues and cell types to phenotypic outcomes\, by leveragin g loci with multiple signals in expression QTL and GWA studies. Major chall enges for this approach involve detection of secondary signals in expressio n QTL studies due to sample size limitations. I will also discuss integrati on of data from massively parallel reporter assays (MPRA)\, and how these d ata may help model dosage effects of genes on GWAS traits\, disentangling c omplex signals that may be obscured by linkage disequilibrium.
CATEGORIES:Spring 2024 LOCATION:Connor Auditorium (FLTC) GEO:0;0 ORGANIZER;CN="bmarston":MAILTO:bmarston@wustl.edu URL;VALUE=URI:https://genetics.wustl.edu/events/event/mike-love-phdassociat e-professordepartments-of-genetics-biostatisticsuniversity-of-north-carolin a-chapel-hill/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:DAYLIGHT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:20240310T080000 TZNAME:CDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR