Assistant Profes sor
University of Wisconsin-Madison
Talk Title: Multimodal analyses of prefrontal cortical development\, evolution\, and disease< /p>
Abstract: The dorsolateral prefrontal cortex (dlPFC) is an evolutiona rily derived cortical area in primates critical for high-level cognitive fu nctions and implicated in various neurodevelopment disorders. The cells tha t compose the dlPFC\, especially excitatory and inhibitory neurons\, underg o extensive maturation throughout midfetal and late-fetal development\, dur ing which critical neurodevelopmental events\, such as circuit assembly and electrophysiological maturation of neurons\, occur. Despite the relevance of neuronal maturation in several neurodevelopmental and psychiatric disord ers\, the molecular mechanisms underlying this process remain largely unkno wn.
In this seminar\, I will discuss some of ou r recent studies that focused on identifying human-specific features of dlP FC structure and development\, novel regulators of neuronal maturation dur ing a critical period of dlPFC development in primates\, and the molecular and cellular mechanisms that are disrupted in Down syndrome during early po stnatal dlPFC development.
Host: Dr. Joe Dougherty
CATEGORIES:Spring 2026 ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu URL;VALUE=URI:https://genetics.wustl.edu/events/event/sousa-andre-2026/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:DAYLIGHT TZOFFSETFROM:-0600 TZOFFSETTO:-0500 DTSTART:20260308T080000 TZNAME:CDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR