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UID:20241210T1520Z-1733844002.3655-EO-3706-1@10.73.10.188
STATUS:CONFIRMED
DTSTAMP:20260416T170415Z
CREATED:20241210T144521Z
LAST-MODIFIED:20260117T200545Z
DTSTART;TZID=America/Chicago:20260122T120000
DTEND;TZID=America/Chicago:20260122T130000
SUMMARY: Genetics Seminar Series – David H. Spencer\, MD\, PhD
DESCRIPTION: David H. Spencer\, MD\, PhD Associate Professor Department of 
 Medicine\, Division of Oncology WashU Medicine Talk Title: Epimutation hots
 pots in acute myeloid leukemia Abstract:  DNA methylation is altered in nea
 rly all cancers\, but the origin and functional consequences of these chang
 es are not well understood. I will present recent studies from our lab show
 ing that […]
X-ALT-DESC;FMTTYPE=text/html: <h4><strong>David H. Spencer\, MD\, PhD</stro
 ng></h4><p>Associate Professor</p><p>Department of Medicine\, Division of O
 ncology</p><p>WashU Medicine</p><p>Talk Title: <i>Epimutation hotspots in a
 cute myeloid leukemia</i></p><p>Abstract:  DNA methylation is altered in ne
 arly all cancers\, but the origin and functional consequences of these chan
 ges are not well understood. I will present recent studies from our lab sho
 wing that regions with intermediate DNA methylation in normal hematopoietic
  cells are "hotspots" for methylation changes in acute myeloid leukemia (AM
 L). We found that intermediate methylation at these hotspots is caused by r
 andom allele-specific methylation in normal hematopoietic stem cells\, and 
 that loss of this "somatic imprinting" pattern results in stable\, clonal e
 pimutations that can precede AML development.</p><p>Host: Dr. Tim Schedl</p
 ><p><img class="alignnone wp-image-4606 size-full" src="https://genetics.wu
 stl.edu/app/uploads/2024/12/1-15.png" alt="" width="1545" height="2000" /><
 img class="alignnone wp-image-4607 size-full" src="https://genetics.wustl.e
 du/app/uploads/2024/12/2-14.png" alt="" width="1545" height="2000" /></p>
CATEGORIES:Spring 2026
LOCATION:Moore Auditorium
GEO:38.635193;-90.262646
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/spencer-david-2026/
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TZID:America/Chicago
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TZOFFSETFROM:-0500
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DTSTART:20251102T070000
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