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UID:20241210T1424Z-1733840674.542-EO-3675-1@10.73.10.188
STATUS:CONFIRMED
DTSTAMP:20260414T233852Z
CREATED:20241210T142203Z
LAST-MODIFIED:20250905T204045Z
DTSTART;TZID=America/Chicago:20250918T120000
DTEND;TZID=America/Chicago:20250918T130000
SUMMARY: Genetics Seminar & Stormo Lecture: Timothy Hughes\, PhD
DESCRIPTION: Timothy R. Hughes\, PhD Professor\, Donnelly Centre for Cellul
 ar and Biomolecular Research Chair and Graduate Chair\, Department of Molec
 ular Genetics\, University of Toronto Title: Codebook: sequence specificity
  of human transcription factors Host: Michael A. White\, PhD Abstract: The 
 human genome encodes hundreds of apparent transcription factors (TFs) for w
 hich the sequence specificity is either unknown or […]
X-ALT-DESC;FMTTYPE=text/html: <h4>Timothy R. Hughes\, PhD</h4><p>Professor\
 , Donnelly Centre for Cellular and Biomolecular Research</p><p>Chair and Gr
 aduate Chair\, Department of Molecular Genetics\, University of Toronto</p>
 <p><strong>Title:</strong> <em>Codebook: sequence specificity of human tran
 scription factors</em></p><p><strong>Host:</strong> Michael A. White\, PhD<
 /p><p><strong>Abstract:</strong> The human genome encodes hundreds of appar
 ent transcription factors (TFs) for which the sequence specificity is eithe
 r unknown or poorly described.  The Codebook Consortium is an international
  collaborative effort to generate the data required to derive accurate moti
 f models for these proteins\, using a battery of in vitro techniques\, as w
 ell as in living cells.  The resulting data (a) demonstrate that most of th
 em are bona fide TFs\, (b) show that many bind transposons and other genomi
 c dark matter\, (c) underscore the high diversity and specificity of human 
 TF binding motifs (d) identify binding factors for tens of thousands of con
 served elements\, and (e) provide an unprecedented opportunity to evaluate 
 and dissect motif models.</p><p><img class="alignnone wp-image-4355 size-fu
 ll" src="https://genetics.wustl.edu/app/uploads/2024/12/1-1.png" alt="" wid
 th="1545" height="2000" /> <img class="alignnone wp-image-4356 size-full" s
 rc="https://genetics.wustl.edu/app/uploads/2024/12/2-1.png" alt="" width="1
 545" height="2000" /></p>
CATEGORIES:Fall 2025
LOCATION:Connor Auditorium
GEO:38.635470;-90.262723
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/timhughes/
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DTSTART:20250309T080000
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