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UID:20241210T1432Z-1733841150.2328-EO-3687-1@10.73.10.188
STATUS:CONFIRMED
DTSTAMP:20260417T200101Z
CREATED:20241210T143213Z
LAST-MODIFIED:20251208T215438Z
DTSTART;TZID=America/Chicago:20251211T120000
DTEND;TZID=America/Chicago:20251211T130000
SUMMARY: Genetics Seminar Series – Priyanka Verma\, PhD
DESCRIPTION: Priyanka Verma\, PhD Assistant Professor\, Dept. of Medicine\,
  Division of Oncology WashU Medicine Talk Title: Deep mutational scanning o
 f a chromatin remodeler uncovers a new therapeutic strategy for BRCA-mutant
  cancers Abstract: We have identified that the loss of ATPase activity of a
  chromatin remodeling enzyme\, Amplified in Liver Cancer 1 (ALC1)\, is synt
 hetically lethal in […]
X-ALT-DESC;FMTTYPE=text/html: <h4>Priyanka Verma\, PhD</h4><p>Assistant Pro
 fessor\, Dept. of Medicine\, Division of Oncology</p><p>WashU Medicine</p><
 p>Talk Title: <em>Deep mutational scanning of a chromatin remodeler uncover
 s a new therapeutic strategy for BRCA-mutant cancers</em></p><p>Abstract: W
 e have identified that the loss of ATPase activity of a chromatin remodelin
 g enzyme\, Amplified in Liver Cancer 1 (ALC1)\, is synthetically lethal in 
 BRCA-mutant cancers. By pursuing a deep-mutational scanning of the ATPase d
 omain of ALC1 we have uncovered surface-exposed pockets that are critical f
 or synthetic lethality\, not conserved amongst other ATPases\, and exhibit 
 minimal mutational tolerance\, limiting the chances for acquired resistance
 . Together\, our studies provide a strong foundation for the development of
  a safe and potent therapeutic strategy for combating <em>BRCA</em>-mutant 
 cancers which have few to no curative options.</p><p>Host: Dr. Gabor Egerva
 ri</p><p><img class="alignnone wp-image-4556 size-full" src="https://geneti
 cs.wustl.edu/app/uploads/2024/12/1-13.png" alt="" width="1545" height="2000
 " /> <img class="alignnone wp-image-4557 size-full" src="https://genetics.w
 ustl.edu/app/uploads/2024/12/2-12.png" alt="" width="1545" height="2000" />
 </p>
CATEGORIES:Fall 2025
LOCATION:Connor Auditorium
GEO:38.635470;-90.262723
ORGANIZER;CN="Michelle Gibbs":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://genetics.wustl.edu/events/event/verma-priyanka-2025/
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TZOFFSETFROM:-0500
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DTSTART:20251102T070000
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