garystormoGary Stormo, Professor.

Gary Stormo is the Joseph Erlanger Professor in the Department of Genetics and the Center for Genome Sciences and Systems Biology at Washington University School of Medicine in St Louis. He received his B.S. degree in biology from the California Institute of Technology and his Ph.D. in molecular biology from the University of Colorado at Boulder. He remained at the University of Colorado as a faculty member in the Department of Molecular, Cellular and Developmental Biology until joining the faculty at WUSM in 1999. Beginning with his graduate thesis work he has combined experimental and computational approaches to understanding gene regulation. Most of that work has focused on identifying, modeling and predicting regulatory sites in DNA and RNA and their contributions to regulatory networks that control gene expression in vivo.

kennystormoYiming (Kenny) Chang, Ph.D.

Yiming Chang has a B.A. in Genetics from Rutgers University and an M.S. in Biotechnology from University of Pennsylvania. He is currently a Ph.D. student in the Molecular Genetics and Genomics program at Washington University in St. Louis. The focus of his research is on understanding the in vitro DNA binding preference of proteins that bind cooperatively.

davidstormoDavid Granas, research

David Granas is a research assistant for the lab. His undergraduate education was from the University of Colorado at Boulder.

manishistormoManishi Pandey, Ph.D. student.

Manishi Pandey is a DBBS graduate student in the Computational and System Biology program at Washington University in St. Louis. She is co-mentored by Prof. Gary Stormo and Prof. Susan Dutcher. Manishi is interested in understanding the role of spliceosome proteins in splice site recognition. More specifically, her work examines non-core splicing factors and their role in defining the global splicing pattern in Chlamydomonas reinhardtii.

basabstormoBasab Roy, postdoctoral researcher.

Basab Roy graduated from Presidency University with a bachelor’s in Chemistry, and received a Master’s in Genetics from Calcutta University. During his Ph.D. he primarily investigated the biochemical pathway by which the glycopeptidic antibiotic, bleomycin, binds and cleaves DNA. Another major focus of his research involved studying the cooperative roles of RNA-binding proteins in regulation of transcription. In 2014, Roy earned a Ph.D. in Biochemistry from Arizona State University, and the following year he joined the Stormo lab at Washington University’s Department of Genetics for his postdoctoral training. While working in an interphase of molecular biology and computation, Roy developed a quantitative DNA binding model of STAT1 by using a method called Spec-Seq (Specificity by Sequencing). Currently he is expanding his research on studying the role of epigenetics on DNA-binding properties of transcription factors with multiple zinc-finger binding domains.

shuxiangstormoShuxiang Ruan, Ph.D.

Shuxiang Ruan is working on a Ph.D. in Computational and Systems Biology at Washington University in St. Louis, St. Louis, MO. He got his Bachelor’s degree in Chemical Biology at Tsinghua University, Beijing, China from 2007-2011. Ruan became a graduate research assistant in Dr. Stormo’s lab in 2012. He’s developed a statistical method for estimating the interaction energy between two nucleotides in a DNA sequence motif and implemented an expectation-maximization algorithm for motif discovery based on mathematical modeling of protein-DNA interactions. In 2011, Ruan started as a rotation student in Dr. Stormo’s lab, where he implemented an algorithm for evaluating position weight matrix models on ChIP-seq data.

zhengstormoZheng Zuo, postdoctoral

Zheng Zuo is a postdoctoral researcher in Dr. Stormo’s lab. He holds Ph.D. in Biomedical Engineering from Washington University in St. Louis and a B.S. in Physics from Peking University. During his Ph.D. years, he successfully developed a high-throughput sequencing based method, Spec-seq, to quantify transcription factor-DNA interaction specificity in high-throughput way with unprecedented resolution up to 0.1kT. Working with his colleague Yiming Chang and collaborator Dr. Jauch, this approach was generalized to study protein-protein interaction, such as Oct4 and Sox2, called Coop-seq. Most recently, Zuo is combining Spec-seq with other newly developed technique, such as competitive fluorescent anisotropy, to address some molecular mechanism related to human disease, e.g., transient neonatal diabetes. At the same time, he proved that modified version of Spec-seq can detect methylation sensitivity of protein-DNA interaction, i.e., Methyl-Spec-seq. Zuo was awarded the Cold Spring Harbor Asia Fellowship in Suzhou, Oct 2014. Besides work, he practices triathlon in spare time. Zuo won age group first place in the Annual JCC indoor triathlon in February 2017.