Dougherty Lab has paper published in Translational Psychiatry

The Dougherty Lab had a paper published in Translational Psychiatry, “Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.” Bernie Mulvey, a grad student in the lab, is lead author on...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.” Tomás Lagunas Jr, a graduate student in the lab, is lead author on the...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Functional connectivity of the developing mouse cortex.” Rachel Rahn, a graduate student in the lab, is lead author. Congratulations, all!

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model.” Kayla Nygaard, a graduate student in the lab, is lead author on the preprint. Congratulations, all!

Dougherty Lab publishes a new paper

The Dougherty Lab has a new paper published in the Journal of Neurodevelopmental Disorders, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint....

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is lead author on the preprint. David Gutmann, MD, PhD, Director, Washington...

Dougherty Lab publishes a paper in Nature Communications

The Dougherty Lab published a paper in Nature Communications, “Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.” Lead author is Kristina Sakers, PhD, a former graduate student in the...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays.” Bernie Mulvey, a grad student in the lab, is first author. Joe Dougherty, PhD, Associate...

Dougherty Lab contributes to new paper in Science Advances

The Dougherty Lab contributed to a new paper published in Science Advances, “Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.” Andrew Luskin, a former graduate student in the Department of Anesthesiology at Washington...

Dougherty Lab has a new paper in Behavioral Neuroscience

The Dougherty Lab has a new paper in Behavioral Neuroscience, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, Assistant Professor of Pediatrics at...

Dougherty Lab postdoc has a new preprint

Mike Vasek, a postdoc in the Dougherty Lab, has a new preprint, “Microglia perform local protein synthesis at perisynaptic and phagocytic structures.” Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University School of...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.” The preprint shares the lab’s work on the MYT1L gene and its...

Dougherty Lab contributes to paper in Cell Reports

The Dougherty Lab contributed to a paper by the Gabel Lab in Cell Reports, “DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.” Diana Christian and Dennis Wu, graduate...

Dougherty Lab publishes new review in Biological Psychiatry

The Dougherty Lab published a review in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.” Bernie Mulvey and Tomás Lagunas Jr., graduate students in the lab, are lead...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Identification of compounds enhancing Aqp4 stop codon readthrough.” Darshan Sapkota, a postdoc in the lab, is lead author. Joe Dougherty, PhD, Associate Professor of Genetics and Psychiatry at Washington University...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “Shared developmental gait disruptions across two mouse models of neurodevelopmental disorders.” Rachel Rahn, a graduate student in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor of...

Dougherty Lab has new preprint

The Dougherty Lab has a new preprint, “Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice.” Elena Minakova, MD, a collaborating researcher in the lab and a a neonatologist at...

Dougherty Lab has a new preprint

The Dougherty Lab has a new preprint, “TRAP-based allelic translation efficiency imbalance analysis to identify genetic regulation of ribosome occupancy in specific cell types in vivo.” The work was done in collaboration with the Lawson Lab. Yating Liu, a...

Mitra Lab publishes paper in Cell

The Mitra Lab recently published a paper in Cell, “Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cell.” Arnav Moudgil, a graduate student in the Mitra Lab, is first author on the paper....

Wang Lab and Dougherty Lab publish paper in Science Advances

The Wang Lab and Dougherty Lab published a paper recently in Science Advances, “DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods.” Yu He, a former graduate student in the...

Former Dougherty Lab grad student lead author on new preprint

Chengran Yang, a former graduate student in the Dougherty Lab, is lead author on a new preprint, “Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traits.” Congratulations, Chengran!

Dougherty Lab publishes paper in Biological Psychiatry

The Dougherty Lab recently published a paper in Biological Psychiatry, “Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants across Biological Contexts.” Bernie Mulvey, a graduate student in the lab, is first author. Tomás...

Dougherty Lab publishes new paper in Human Molecular Genetics

The Dougherty Lab published a paper in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences.” Nathan Kopp, a former graduate student in the lab, and Kayla...

Dougherty Lab publishes new paper in Brain and Behavior

The Dougherty Lab published a new paper in Brain and Behavior, “The trajectory of gait development in mice.” Shyam Akula, a former undergraduate researcher in the lab, is first author on the paper. Joe Dougherty, PhD, Associate Professor of Genetics at...

Dougherty Lab publishes paper in Human Molecular Genetics

The Dougherty Lab recently had a paper published in Human Molecular Genetics, “Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences.” Nathan Kopp, PhD, a former graduate student in the...

Dougherty Lab undergrad awarded BioSURF fellowship

Jelani Deajon-Jackson, an undergraduate student in the Dougherty Lab, was recently awarded a BioSURF fellowship by Washington University in St. Louis to train with his mentor Mike Vasek, a postdoc in the lab. The Washington University Biology Summer Undergraduate...

Dougherty and Mitra Labs publish paper in PNAS

The Dougherty and Mitra Labs had a paper published in PNAS, “A viral toolkit for recording transcription factor–DNA interactions in live mouse tissues.” Alex Cammack, a graduate student in the Miller Lab who recently defended, is first author on the paper....

Dougherty Lab has new preprint

The Dougherty Lab has a new preprint, “Activity-dependent translation in astrocytes.” Darshan Sapkota, a postdoc in the lab, is first author on the preprint. Joe Dougherty, PhD, Associate Professor in the Department of Genetics at Washington University...

Dougherty Lab publishes a new paper in Scientific Reports

The Dougherty Lab recently had a paper published in Scientific Reports, “CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system.” Yating Liu, a programmer in the lab, is an author on the paper,...

Dougherty Lab publishes new paper in Neural Development

The Dougherty Lab has a new paper in Neural Development, “An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells.” Darshan Sapkota, a postdoc in the lab, is first author on the paper. Joe Dougherty, PhD,...

Dougherty Lab welcomes new members

The Dougherty Lab recently welcomed new members including Rachael, a senior graduate student who will be working with Kayla Nygaard, a graduate student in the lab; Chayla, a first year PhD rotation student working with Bernie Mulvey, a graduate student in the lab;...

Dougherty Lab publishes paper in Human Molecular Genetics

The Dougherty Lab had a paper published recently in Human Molecular Genetics. The paper, “Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models,” thoroughly defines a set of...

Dougherty Lab presents at Society for Neuroscience annual meeting

The Dougherty Lab recently presented at the annual Society for Neuroscience meeting in Chicago. Dr. Susan Maloney, Instructor in Psychiatry and a member of the Dougherty Lab, presented on modeling social motivation in the mouse and the role of Shank3B and the oxytocin...

Reshma Bhagat joins Dougherty Lab as postdoc

Reshma Bhagat has joined the Dougherty Lab as a postdoc. Dr. Bhagat comes from a background studying molecular perturbations in neural cell types elicited by Zika virus components. Check out Dr. Bhagat’s work here.

Dougherty Lab postdoc gets K99 award for Alzheimer’s project

Darshan Sapkota, Ph.D., a postdoctoral researcher in the Dougherty Lab, got funding for his K99 application. With this grant, Darshan will study the role of a new variant of Aquaporin 4 protein in brain function and Alzheimer’s disease. Aquaporin 4 is a water...

Dougherty Lab publishes paper about EWOCs and autism research

The Dougherty Lab published a paper recently in Autism Research, “Erroneous inference based on a lack of preference within one group: Autism, mice, and the social approach task.” The paper looks at  Erroneous Within‐group Only Comparisons, or EWOCs, a term...

Dougherty Lab awarded grant for fetal opioid exposure project

The Dougherty Lab was recently awarded a pilot grant from the Center for Clinical Pharmacology for its project, “A new model to understand the developmental deficits associated with fetal exposure to opioids.” Principal Investigators are Ream Al-Hasani,...

Dougherty lab shares new preprint arguing against EWOCs

The Dougherty lab recently shared its new preprint, “Erroneous inference based on a lack of preference within one group: autism, mice, and the Social Approach Task.” In the paper, the lab argues using statistical principles and data simulations that...

Dougherty lab graduate student accepts postdoc position at UCLA

Nathan Kopp, a graduate student in the lab of Joe Dougherty, Ph.D., Associate Professor in the Department of Genetics, recently was accepted to a dual clinical genetic counseling/postdoc position at UCLA. Congratulations, Nathan! Read more about Nathan and his work in...

Dougherty lab publishes paper on local translation in neurites

The Dougherty lab had a paper published recently in eNeuro. The paper, “The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms,” suggests that differences in...

Dougherty lab publishes paper on autism and SSRI exposure

The Dougherty lab published a paper recently in eNeuro. The paper, “Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure,” looks at how maternal fluoxetine treatment can induce behavioral disruptions in...