Schedl Lab

Washington University Genetics


Research Publications

Brenner JL, Schedl, T. Germline stem cell differentiation entails regional control of cell fate regulator GLD-1 in Caenorhabditis elegans. 2016, Genetics, 202:1085-1103.  Brenner and Schedl 2016_PDF Brenner and Schedl 2016_Supplement_PDF

Howe KL, Bolt BJ, Cain S, Chan J. et al.  WormBase 2016: expanding to enable helminth genomic research. Nucleic Acids Res. 44:D774-D780

Rastogi, S, Borgo, B, Pazdernik, N, Fox, PM, Mardis, ER, Kohara, Y, Havranek, J, Schedl, T, C. elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase. 2015, G3, 5:2719-2728.  PDF

Fox, PM, Schedl, T. Analysis of germline stem cell differentiation following loss of GLP-1 Notch activity in C. elegans, 2015, Genetics, 201:167-184.  PDF

Hou, X, Zhang, L, Han, L, Ge, J, Ma, R, Zhang, X, Moley, K, Schedl, T, Wang, Q. Differential function of pyruvate dehydrogenease kinases during mouse ooctye maturation. 2015, J. Cell Sci, 128:2319-2329. PDF

Zhang, L, Han, L, Ma, R, Hou, X, Yu, Y, Sun, S, Xu, Y, Schedl, T, Moley, K, Wang, Q. Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes. 2015, Cell Cycle, In Press  PDF

Ma, R, Hou, X, Zhang, L, Sun, S, Schedl, T, Moley, K, Qiang Wang, Q. Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis in oocytes. 2014, FASEB Journal, 28:4026-4035.  PDF

Zhang, L, Hou, X, Ma, R, Moley, K, Schedl, T, Wang, Q. Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. 2014, FASEB Journal, 28:1435 – 1445.  PDF

Harris TW, Baran J, Bieri T, Cabunoc A, et al. WormBase 2014: new views of curated biology. 2014 Nucleic Acids Res. 42:D789-93. PDF

Arur, S, and Schedl, T. Generation and purification of highly-specific antibodies for detecting post-translationally modified proteins in vivo. 2014; Nature Protocols, 9:375-395.  PDF

Taylor, CM, Wang, Q, Rosa, BA, Huang, S, Powell, K, Schedl, T, Pearce, EJ, Abubucker, S, Mitreva, M. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. 2013; PLoS Pathogens, 9:e1003505. PDF

Luzzo, KM, Wang, Q, Purcell, SH, Chi, M, Jimenez, PT, Grinder, N, Schedl, T, Moley, KH. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. 2012; PLoS One, 7:e49217.  PDF

Wang, Q. Chi, M, Schedl, T. and Moley, K. An intercellular pathway for glucose transport into mouse oocytes. 2012; American Journal of Physiology – Endocrinology and Metabolism, 302:E1511-1518.  PDF

Wang, C, Wilson-Berry, L, Schedl, T, and Hansen, D. TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. 2012; Developmental Dynamics, 241:505-521. PDF

Arur, S, Ohmachi, M, Berkseth, M, Nayak, S, Hansen, D, Zarkower, D, and Schedl, T. MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex determination module. 2011; Developmental Cell, 20:677-688.  PDF Supplement

Fox, P, Vought, V, Hanazawa, M, Lee, M-H, Maine, E, and Schedl, T. Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. 2011; Development, 138:2223-2234.  PDF Supplement

Green, R, Kao, H, Audhya A, Arur, S, Schulman, M, Schloissnig, S, Niessen, S, Laband, K, Wang, S, Hyman, A, Desai, A, Schedl, T, Piano, F. Gunsalus, K. Oegema, K.  A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue. 2011; Cell, 145:470-482.  PDF

Rangarajan, A, Schedl, T, Yook, K, Chan, J, Haenel, S, Otis, L, Faelten, S, DePellegrin-Connelly, T, Isaacson, R, Skrzypek, M, Cherry, M, Sternberg, P, and Muller, H-M.  Towards an interactive article: intergrating journals and biological databases. 2011; BMC Bioinforamtics, 12:175.  PDF

Wang Q, A. Frolova, K. Adastra, S. Purcell, E. Schoeller, M. Chi, T. Schedl, and Moley, K. Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. 2010; PLoS ONE, 5:e15901-e15911.  PDF

Kerins, JA, Hanazawa, M, Dorsett, M, Schedl, T.  PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans. Developmental Dynamics. 2010, 239:1555-1572   PDF

Howell, K, Arur, S, Schedl, T, and Sundaram, M.  EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in C. elegans. Genetics. 2010  184: 899–913 PDF

Dorsett, M. and Schedl, T. A role for dynein in the inhibition of germ cell proliferative fate. Molecular Cell Biology.  2009  29:6128-6139.  PDF

Dorsett, M., B. Westland and T. Schedl.  METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans. Genetics. 2009 183:233-247. PDF

Wang, Q, Ratchford, A, Chi, M, Schoeller, E, Frolova, A, Schedl, T, and Moley, K. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Molecular Endocrinology. 2009  23:1603-1612. PDF

Arur, S, Ohmachi, M, Nayak, S, Hayes, M, Miranda, A, Hay, A, Golden, A, and Schedl, T. Multiple ERK substrates execute single biological processes in C. elegans germline development. Proc. Nat Acad. Sci. 2009  106:4776-4781.  PDF Supplement

Hillier, L, Marth, G, Quinlan, A, Dooling, D, Fewell, G, Barnett, D, Fox, P, Glasscock, J, Hickenbotham, M, Huang, W, Magrini, V, Richt, R, Sander, S, Stewart, D, Stromberg, M, Tsung, E, Wylie, T, Schedl, T, Wilson, R, and Mardis, E. Whole Genome Sequencing and Variant Discovery in C. elegans. Nature Methods. 2008  5:183-8.  PDF

Lee, M. H, M. Ohmachi, S. Arur, S. Nayak, R. Francis, Church, D, Lambie, E, and Schedl, T. Multiple functions and dynamic activation of MPK-1 ERK signaling in C. elegans germline development. Genetics. 2007  177:2039-2062. PDF

Jantsch, V, Tang, L, Pasierbek, P, Penkner, A, Nayak, S, Baudrimont, A,  Schedl, T. Gartner, A, and Loidl, J. C. elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing. 2007; Molecular Biology of the Cell. 2007 18:4911-4920. PDF Supplement

Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann R, Hengartner M, Schedl T, Gartner A. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Cell. 2005 Feb 11;120(3):357-68. PDF

Nayak S, Goree J, Schedl T. fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis. PLoS Biol. 2005 Jan;3(1):e6. Epub 2004 Dec 28. PDF

Tian X, Hansen D, Schedl T, Skeath JB. Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development. 2004 Dec;131(23):5807-15. PDF

Lee MH, Schedl T. Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans. Genes Dev. 2004 May 1;18(9):1047-59. Epub 2004 Apr 22. PDF

Hansen D, Hubbard EJ, Schedl T. Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline. Dev Biol. 2004 Apr 15;268(2):342-57. PDF

Wiederkehr C, Basavaraj R, Sarrauste de Menthiere C, Hermida L, Koch R, Schlecht U, Amon A, et al.  GermOnline, a cross-species community knowledgebase on germ cell differentiation. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D560-7. PDF

Hansen D, Wilson-Berry L, Dang T, Schedl T. Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation. Development. 2004 Jan;131(1):93-104. Epub 2003 Dec 3. PDF

Primig M, Wiederkehr C, Basavaraj R, Sarrauste de Menthiere C, Hermida L, Koch R, Schlecht U, et al.  GermOnline, a new cross-species community annotation database on germ-line development and gametogenesis. Nat Genet. 2003 Dec;35(4):291-2. PDF

Ohmachi M, Rocheleau CE, Church D, Lambie E, Schedl T, Sundaram MV. C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr Biol. 2002 Mar 5;12(5):427-33. PDF

Nayak S, Santiago FE, Jin H, Lin D, Schedl T, Kipreos ET. The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Curr Biol. 2002 Feb 19;12(4):277-87. PDF

Hsu V, Zobel CL, Lambie EJ, Schedl T, Kornfeld K. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics. 2002 Feb;160(2):481-92. PDF

Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell. 2001 Oct 5;107(1):27-41. PDF

Lee MH, Schedl T. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Genes Dev. 2001 Sep 15;15(18):2408-20. PDF Supplement

Miller MA, Nguyen VQ, Lee MH, Kosinski M, Schedl T, Caprioli RM, Greenstein D. A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation. Science. 2001 Mar 16;291(5511):2144-7. PDF

Clifford R, Lee MH, Nayak S, Ohmachi M, Giorgini F, Schedl T. FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. Development. 2000 Dec;127(24):5265-76. PDF

Kuwabara PE, Lee MH, Schedl T, Jefferis GS. A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Genes Dev. 2000 Aug 1;14(15):1933-44. PDF

McCarter J, Bartlett B, Dang T, Schedl T. On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans. Dev Biol. 1999 Jan 1;205(1):111-28. PDF

Berry LW, Westlund B, Schedl T. Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development. 1997 Feb;124(4):925-36. PDF

McCarter J, Bartlett B, Dang T, Schedl T. Soma-germ cell interactions in Caenorhabditis elegans: multiple events of hermaphrodite germline development require the somatic sheath and spermathecal lineages. Dev Biol. 1997 Jan 15;181(2):121-43. PDF

Jones AR, Francis R, Schedl T. GLD-1, a cytoplasmic protein essential for oocyte differentiation, shows stage- and sex-specific expression during Caenorhabditis elegans germline development. Dev Biol. 1996 Nov 25;180(1):165-83. PDF

Crowder CM, Shebester LD, Schedl T. Behavioral effects of volatile anesthetics in Caenorhabditis elegans. Anesthesiology. 1996 Oct;85(4):901-12. ABSTRACT

Iwasaki K, McCarter J, Francis R, Schedl T. emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation. J Cell Biol. 1996 Aug;134(3):699-714. PDF

Kloek AP, McCarter JP, Setterquist RA, Schedl T, Goldberg DE. Caenorhabditis globin genes: rapid intronic divergence contrasts with conservation of silent exonic sites. J Mol Evol. 1996 Aug;43(2):101-8. PDF

Jones AR, Schedl T. Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev. 1995 Jun 15;9(12):1491-504. PDF

Francis R, Maine E, Schedl T. Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway. Genetics. 1995 Feb;139(2):607-30. PDF

Francis R, Barton MK, Kimble J, Schedl T. gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics. 1995 Feb;139(2):579-606. PDF

Graham PL, Schedl T, Kimble J. More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans. Dev Genet. 1993;14(6):471-84. PDF

Seydoux G, Schedl T, Greenwald I. Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans. Cell. 1990 Jun 15;61(6):939-51. PDF

Schedl T, Graham PL, Barton MK, Kimble J. Analysis of the role of tra-1 in germline sex determination in the nematode Caenorhabditis elegans. Genetics. 1989 Dec;123(4):755-69. PDF

Schedl T, Kimble J. fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans. Genetics. 1988 May;119(1):43-61. PDF

Barton MK, Schedl TB, Kimble J. Gain-of-function mutations of fem-3, a sex- determination gene in Caenorhabditis elegans. Genetics. 1987 Jan;115(1):107-19. PDF

Selected Reviews, Methods & Book Chapters:

Lee, M-H. and Schedl, T.  C. elegans STAR proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development. In Post-transcriptional regulation by STAR proteins: control of RNA metabolism in Development and Disease.  Edited by Volk, T. and Atrzt. 2010 PDF

Hansen, D. and Schedl, T. The regulatory network controlling the proliferation – meiotic entry decision in the C. elegans germ line. In Current Topics in Developmental Biology. 2006, 76:185-215.  PDF

Ellis, R. and Schedl, T.  Sex determination in the germ line. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.82.1  2006  PDF

Lee, R. and Schedl, T:  RNA-binding proteins. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.79.1  2006  PDF

Lee, M.-H. and Schedl, T.  RNA in situ hybridization of dissected gonads. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.107.1  2006 PDF

Seydoux G, Schedl T. The germline in C. elegans: origins, proliferation, and silencing. Int Rev Cytol. 2001;203:139-85. Review. ABSTRACT

Schedl T. Developmental genetics of the germline. In The Nematode Caenorhabditis elegans II.  Edited by Riddle, D, Blumenthal, T, Meyer B and Priess J. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 1997  241-269.

Additional Research Publications By Members While In The Laboratory

Goldstein, J, Glossip, D, Nayak, S, Kornfeld, K.  The CRAL/TRIO and GOLD Domain Protein CGR-1 Promotes Ras Mediated Signaling in C. elegans. Genetics. 2006  172: 929 – 942.  PDF

Vought V, Ohmachi, M, Lee, M-H, Maine, E.  EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/Notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis elegans. Genetics. 2005. 170:1121-1132. PDF

Maine, E, Hansen, D, Springer, D, Vought V.  Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate. Genetics. 2004.  168:817-830.  PDF

Kelly, W., Schaner, C, Dernburg, A, Lee, M-H, Kim, S, Villeneuve, A, Reinke, V.  X-chromosome silencing in the germline of C. elegans. Development. 2002  129:479-492.  PDF

  • Tim Schedl, Ph.D
    Department of Genetics
    Campus Box #8232
    Washington University School of Medicine
    4566 Scott Ave.
    St. Louis, MO 63110


    PHONE: (314)362-6164 [lab]
    FAX: (314)362-7855