A collaborative research effort between laboratories at Washington University School of Medicine has identified molecular and cellular mechanisms by which a ketogenic diet (KD) alters synaptic communication in the brain — revealing how metabolic state can reshape neuronal networks at the transcriptional, epigenetic, and physiological levels. Spearheaded by first authors Marion Stunault, PhD, Pan-Yue Deng, PhD and Anjali Yadav, PhD, the study, “Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools,” was recently published in Cell Reports and provides foundational insight into how diet-induced metabolic changes influence excitatory circuits in the hippocampus.
Researchers decode how a ketogenic diet modifies brain synaptic function
