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Postdoctoral Research Associate position is available immediately in the Departments of Genetics the Washington University in St. Louis. The Turner Lab at WashU in St. Louis focuses on advancing the emerging field of Precision Genomics, which we define as “determining all possible relevant genomic variation within an individual to the precise nucleotide.” Precision Genomics is a cornerstone under the umbrella of Precision Medicine, addressing critical challenges in genomic interpretation and translation.

PI: Michael Province, PhD

I am interested in the development and application of statistical genetics analysis methods for human complex traits and diseases. This includes gene discovery and validation in genomic scans (association, gene expression, and copy number), pathway analysis, and the design of family/genetic observational studies and clinical trials. I have developed growth curve pharmacogenetic models of treatment effect, Poisson-Process genetic models, frailty (age-at-onset) models, recursive partitioning genetic methods, meta-analysis procedures, and novel Sequential Multiple Decision Procedures to simultaneously identify all signals in a genome scan while controlling for overall type I and type II error rates.

The Ushiki Lab investigates the molecular mechanisms of transcriptional regulation and how noncoding genetic variation alters gene regulation in human disease. Our work integrates functional genomics, human genetics, and in vivo experimental systems to understand enhancer function across regulatory and phenotypic scales. We develop and apply both experimental and computational approaches, including in vivo Massively Parallel Reporter Assays (MPRAs), to define the sequence basis and functional consequences of enhancer activity and to expand MPRA-based approaches to other aspects of transcriptional regulation. Ongoing work in the lab is supported by an NHGRI K99/R00 award and the Preeclampsia Foundation’s Peter Joseph Pappas Research Grant. In particular, this position will contribute to projects investigating the relationship between enhancer function and transcriptional elongation, termination, and RNA processing/splicing.

This Research Tech position, under the supervision of Dr. Tychele Turner, is an exceptional opportunity to contribute significantly to cutting-edge research on neurodevelopmental disorders. This role is focused on wet-lab methodologies specifically. This position not only promises a dynamic and stimulating work environment, but also offers a platform to make impactful advancements in the understanding and treatment of neurodevelopmental conditions.

PI: Nancy Saccone, PhD

Our research uses mathematical and statistical methods to identify and characterize genetic contributors to complex traits in humans. Methods under development include use of linkage disequilibrium (LD) structure in the design and interpretation of disease association studies. Applied work and interdisciplinary collaborations focus on the genetics of substance dependence.

PI: Tim Schedl, PhD

We investigate: 1) The decision between germline stem cell proliferation and meiotic development 2) Progression through meiotic prophase & gametogenesis 3) Mitochondria and germline development 4) Germline sex determination 5) In collaboration with Drs Qiang Wang and Kelle Moley we also investigate mouse oocyte maturation and the consequences of physiological perturbations including high fat diet and diabetes

The Senior Scientist in the Cremins Lab will work with a dynamic team to conduct research in the area of sequencing and analysis of complex multimodal genomics data. Collaborate with the team to design, optimize, and standardize experimental and analysis pipelines to accelerate high-quality publications. Develop new code and statistical methods to analyze genomics and spatial transcriptomics datasets to map the neural connectome. They will also be responsible for maintaining and organizing lab records, training junior scientists on technical assays, preparing and reviewing manuscripts, and helping with grant applications.

The Cremins lab works at the spatial biology-technology interface to understand chromatin-to-synapse communication during neural circuit activation in the mammalian brain. We aim to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.

PI: Jim Skeath, PhD

We investigate the genetic and molecular basis of both asymmetric divisions and cell-type specific differentiation programs through the use of the Drosophila model system, focusing primarily on nervous system development.

The Cremins lab works at the spatial biology-technology interface to understand chromatin-to-synapse communication during neural circuit activation in the mammalian brain. We aim to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.