Justin Kinney, PhD, Associate Professor, Cancer Center Program Co-Leader, Cold Spring Harbor Laboratory

Presents:  Massively parallel reporter assays, quantitative sequence-function relationships, and splice-modifying drugs

Host: Dr. Mike White

In person only: Connor Auditorium

Abstract: My lab studies the biophysical mechanisms of transcriptional regulation and alternative mRNA splicing. To do this we use massively parallel reporter assays and machine learning/AI methods to measure and mechanistically model the quantitative effects that mutations in regulatory sequences have on gene expression. I will provide an overview this research program, focusing in particular on the tightly knit combination of experimental, computational, and mathematical work it involves.