Wanlu Liu, PhD

Visiting Scholar, Stanford University, School of Medicine

Associate Professor, Vice Dean, Zhejiang University

Talk title: Exploring Human T cells and TCRαβ repertoire at the single-cell level: Phenotypic Heterogeneity and Disease Associations

Abstract: T cells represent a dynamic record of a host’s immunological history, where cellular identity and antigen recognition are intrinsically linked. In this talk, I will tell two stories regarding the large scale integration and analysis of single cell multi omics data. First, I will describe the development of scAtlasVAE, a framework that enabled us to build a comprehensive human CD8 T cell atlas across 68 studies, uncovering conserved phenotypic transitions in cancer and inflammation. Second, I will introduce TCR-DeepInsight, a transformer based model that jointly represents T cell receptor sequences and gene expression to identify disease associated clonotypes at a population level. Together, these methods provide a roadmap for decoding the rules of immune recognition and cellular fate in human disease.

Host: Dr. Ting Wang