Peng Jin, PhD

Robert W. Woodruff Professor of Human Genetics

Chair, Department of Human Genetics

Director, Emory Stephen T. Warren National Fragile X Research Center

Emory University School of Medicine

Talk title: Two Faces of FMR1: FMRP Deficiency and CGG Repeat-Mediated Neurodegeneration

Abstract: Fragile X–associated disorders arise from distinct consequences of CGG repeat expansion in the FMR1 gene, ranging from loss of FMRP in fragile X syndrome to repeat-mediated toxicity in FXTAS. This talk will highlight our recent work defining how FMRP regulates brain development and how expanded CGG repeats drive neurodegeneration, with the goal of identifying convergent mechanisms and therapeutic opportunities across the fragile X spectrum.

Host: Dr. Jennifer Cremins