Bio5488 Genomics

This course is designed for beginning students who want to become familiar with the basic concepts and applications of genomics. The course covers a wide range of topics including how genomes are mapped and sequenced as well as the latest computational and experimental techniques for calling genomic variants, epigenetic changes like DNA methylation and accessible chromatin, and inferring transcription factor binding sites and motifs. High throughput techniques for ascribing function to DNA, RNA, and protein sequences including single-cell RNA-seq, whole genome sequencing, massively parallel reporter assays, chromosome conformation capture (Hi-C) analysis, and metagenomics will also be discussed. Finally, the use of genomic techniques and resources for studies of human disease will be discussed.