Research interests
My lab is currently focusing on the formation, development, and application of genetic, genomics, and bioinformatics methods to better analyze and integrate exome and genome sequencing, SNP array, RNA-sequencing, epigenomic, metabolomic, and proteomics data. Through integration of diverse types of transcriptomic and epigenetic functional annotations, the integrative genomic analysis will provide a better understanding of the molecular basis of neurodevelopmental disorders and cardiovascular diseases. Our mission is to provide meaningful and interpretable insight into disease biology, and define new targets for risk determination, prevention, and therapy.
NIH Grants
- U19NS130607: INTERCEPT: Integrated Research Center for Human Pain Tissues (Role: Project 1 Co-PI and Data Core Co-PI) (Active)
- UM1DA058219: WashU-VAI Somatic Mosaicism across Human Tissues (SMaHT) Program Genome Characterization Center (Role: Co-Investigator) (Active)
- U24NS132103: WashU Somatic Mosaicism across Human Tissues (SMaHT) Program. Organizational Center (Role: Co-Investigator) (Active)
- R01NS111029: Human Genetics and Molecular Mechanisms of Congenital Hydrocephalus (Role: Co-Investigator) (Active)
- R01AR067715: Genetic Risk Factors for Severe Scoliosis (Role: Co-Investigator) (Active)
- R01NS117609: Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal Malformation (Role: Co-Investigator) (Active)
- R01NS106298: Genomic Insights into the Neurobiology of Cerebral Palsy (Role: Co-Investigator) (Active)
- R01NS127108: Genomic analysis of the Multiplex, Autozygous Populations in Cerebral Palsy (MAP CP) cohort: a focused approach to a complex disease (Role: Co-Investigator) (Active)
Selected Honors and Awards
- NIH Early Career Reviewer Program, 2023
- Pediatric Cardiac Genomics Consortium and Cardiovascular Development Data Resource Center Challenge Prize, 2022
- Cerebral Palsy Alliance Research Foundation Project Grant, 2022-2027
- Hydrocephalus Association Innovator Award, 2021
- Children’s Discovery Institute Faculty Scholar, 2021-2026
- Children’s Discovery Institute Zebrafish Models for Pediatric Research Services Cooperative Micro-Grant Award, 2021
- Washington University Institute of Clinical and Translational Research Funding Program Award, 2020
- K99/R00 Pathway to Independence Award, NHLBI, NIH
- American Heart Association Postdoctoral Fellowship
- James Hudson Brown – Alexander B. Coxe Fellowship, Yale School of Medicine
- Howard Hughes Medical Institute Postdoctoral Fellowship, Howard Hughes Medical Institute at Yale School of Medicine
- Fellow, Lucille P. Markey Special Emphasis Pathway in Human Pathobiology, Markey Foundation, Washington University School of Medicine