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PI: Michael Province, PhD

I am interested in the development and application of statistical genetics analysis methods for human complex traits and diseases. This includes gene discovery and validation in genomic scans (association, gene expression, and copy number), pathway analysis, and the design of family/genetic observational studies and clinical trials. I have developed growth curve pharmacogenetic models of treatment effect, Poisson-Process genetic models, frailty (age-at-onset) models, recursive partitioning genetic methods, meta-analysis procedures, and novel Sequential Multiple Decision Procedures to simultaneously identify all signals in a genome scan while controlling for overall type I and type II error rates.

This Research Assistant position, under the supervision of Dr. Tychele Turner, is an exceptional opportunity to contribute significantly to cutting-edge research on neurodevelopmental disorders. This role is uniquely designed to encompass a comprehensive approach, integrating both wet-lab and dry-lab methodologies. The ideal candidate will possess a well-rounded skill set, with at least a moderate level of proficiency in both domains, ensuring the ability to navigate and contribute effectively to the diverse aspects of the research process.

This is an exciting research opportunity in the Dougherty lab in the Department of Genetics. We are seeking a motivated scientist to join our team! Work in the lab involves conducting rodent behavioral and molecular analyses for NIH-, foundation-, privately-, and university-funded projects. This includes collecting behavioral data, conducting preliminary data quality analysis, maintaining experimental mouse lines, and performing molecular assays for genotype determination. Additional responsibilities and opportunities include statistical analysis and data interpretation, and assisting the team to bring new behavioral assays online. This position requires flexible hours as evening and weekend work may be required as needed on a study by study basis.

This is an exciting research opportunity in the Ushiki Lab at the Department of Genetics, Washington University in St. Louis. We are seeking a motivated candidate to join our team! The lab conducts mouse genetics and molecular biology experiments for projects. Work in the lab includes maintaining experimental mouse lines, performing molecular assays for genotype determination, basic cell culture, and molecular biology experiments. The successful applicant will start in the fall/winter of 2024.

PI: Nancy Saccone, PhD

Our research uses mathematical and statistical methods to identify and characterize genetic contributors to complex traits in humans. Methods under development include use of linkage disequilibrium (LD) structure in the design and interpretation of disease association studies. Applied work and interdisciplinary collaborations focus on the genetics of substance dependence.

PI: Tim Schedl, PhD

We investigate: 1) The decision between germline stem cell proliferation and meiotic development 2) Progression through meiotic prophase & gametogenesis 3) Mitochondria and germline development 4) Germline sex determination 5) In collaboration with Drs Qiang Wang and Kelle Moley we also investigate mouse oocyte maturation and the consequences of physiological perturbations including high fat diet and diabetes

PI: Jim Skeath, PhD

We investigate the genetic and molecular basis of both asymmetric divisions and cell-type specific differentiation programs through the use of the Drosophila model system, focusing primarily on nervous system development.

PI: Gary Stormo, PhD

The Stormo lab is interested in the mechanisms of gene regulation. We use both experimental and computational approaches to determine the specificity of protein-DNA interactions, defining quantitative “motifs” for transcription factors. This allows for predictions of binding sites and the effects of mutations on gene expression. We also study RNA structure and protein-RNA interactions to help uncover post-transcriptional modes of gene regulation.

Individuals with research programs in any area of genetics/genomics are encouraged to apply. The department has historic strength in human genetics, model organism biology, epigenetics and gene regulation, technology development, and computational biology. The department is also home to the McDonnell Genome Institute, one of the largest academic genome centers in the country and a key player in producing the first human genome sequence, the first cancer genome sequence, several surveys of human genetic diversity, and the ongoing human pangenome project.

The Dean’s Fellow to Faculty Program in the Department of Genetics at Washington University School of Medicine rewards outstanding graduate student or early-stage postdoctoral researchers in genetics, genomics, bioinformatics, or computational biology with the opportunity to create an independent research agenda in anticipation of joining the Genetics Department as an Assistant Professor on the tenure-track.