Items

• Jeffrey Milbrandt, MD, PhD | Milbrandt Lab
• Gabor Egervari, MD, PhD | Egervari Lab
• Guoyan Zhao, PhD | Zhao Lab

PI: Tychele Turner, PhD

As a research lab, we excel to achieve the goals of Precision Genomics by addressing five main areas that present as current limitations to Precision Genomics in everyone: 1) interpretation of noncoding variation 2) variants missed due to genomic technology 3) speed of the current “genomic workflow” 4) combination of multi-hit rare and/or common variants 5) gene x environment

PI: Ting Wang, PhD

Our research is to understand the evolution and adaption of human regulatory networks, with a focus on the impact of these processes on human health and disease.In particular, we investigate the evolutionary model of mobile elements (or transposable elements) and their roles in basic biology and cancer, including their genetic and epigenetic regulation.

PI: Michael White, PhD

We use a range of genomic technologies and computational strategies to understand how the photoreceptor transcription factor cone-rod homeobox (CRX) recognizes different target sites in several retinal cell types. We develop massively parallel functional assays to understand how both protein-coding and non-coding genetic variants affect molecular function. We also develop biophysical models of gene regulation that connect DNA sequence and transcription factor binding with gene expression levels.

PI: Guoyan Zhao, PhD

We integrate multiple cutting-edge computational and experimental approaches to study gene transcriptional regulation in the nervous system and how changes in the regulation contribute to neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson disease (PD) and Lewy body diseases (LBDs).