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Dougherty Lab

Genetics and genomics of behavior in health and disease

PI: Joe Dougherty, PhD
The Dougherty Lab is interested in 1) Exploring the genetics and genomics of behavior in health and disease. 2) Employing a diverse range of techniques such as human molecular genetics, informatics, mouse behavior studies, in vitro and in vivo neuroscience, and neuroanatomy. 3) Innovating methods for transgenesis, gene manipulation, and brain transcriptional profiling to develop mouse models that mimic genetic variations found in human patients. Emphasis on understanding the molecular foundations of behavior, with a special focus on neurodevelopmental conditions like the autism spectrum.
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Dutcher Lab

Assembly and function of basal bodies/centrioles and cilia

PI: Susan Dutcher, PhD

The Dutcher Lab studies the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology. Motile cilia play roles in moving cells and fluids. Sensory cilia play essential roles in monitoring the environment. Chlamydmonas uses its flagella (or cilia) in both ways. To build cilia, one needs to have functional basal bodies.

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Egervari Lab

Epigenetics and substance use disorders (SUDs)

PI: Gabor Egervari, MD, PhD

Our laboratory explores the role of metabolic-epigenetic interactions in the healthy and diseased brain, with particular emphasis on substance use disorders and neurodegeneration.

Portrait of Epigenetics
Portrait of Evolutionary & Human Genetics
Gary Stormo, PhD

Gary D. Stormo Computational & Systems Biology Lecture

Stormo Lecture

The Gary D. Stormo Computational & Systems Biology Lectureship was established by the Department of Genetics in 2024, in honor of Dr. Gary D. Stormo, a pioneer in bioinformatics with 24 years of professorship at Washington University School of Medicine.

Portrait of Gene Regulation
Portrait of Genome Technology Development
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Jin Lab

Computational functional genomics

PI: Sheng Chih (Peter) Jin, PhD

Our mission is to provide meaningful and interpretable insight into disease biology, and define new targets for risk determination, prevention, and therapy. We are currently focusing on the formation, development, and application of human genetic, functional genomic, and bioinformatic methods to better analyze and integrate genome sequencing, single-cell RNA-sequencing, epigenomic, spatial genomic, and proteomic data. Through integration of diverse type of omics data and epigenetic functional annotations, the integrative genomic analysis will provide a better understanding of the molecular basis of cardiovascular diseases and neurological disorders. Following integrative genomic analyses, we use zebrafish and massively parallel reporter assays to precisely model human mutations.

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Lawson Lab

Genetics and genomics

PI: Heather A Lawson, PhD

The Lawson Lab addresses important questions about the genotype – phenotype relationship that must be answered to understand variation in metabolic traits. Specifically: Are particular metabolic traits more genetically or epigenetically controlled? How does diet affect the relative contribution of genetics or epigenetics? Do differences in genetic and epigenetic modes of regulation result in discordance among metabolic traits?