Items
Arnold Lab
Neurological disorders
The Arnold Lab studies the molecular mechanisms underlying TDP-43 proteinopathies, a group of neurodegenerative diseases that includes amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and many cases of Alzheimer's disease. The lab investigates how TDP-43 dysfunction contributes to neuronal degeneration and identifies genetic factors that influence disease progression. By combining targeted proteomics, induced pluripotent stem cell (iPSC)-derived neuron models, and genome engineering, the Arnold Lab develops biomarkers and innovative disease models to better understand these disorders and accelerate the discovery of new therapeutic strategies.
BBS 5075 Introduction to Coding and Statistical Thinking for Genetics and Genomics
Work in the life sciences increasingly relies on large scale, quantitative data that requires basic computational and statistics skills. This course is an introduction to basic Python and statistical concepts used in molecular genetics and genomics, aimed at first-year DBBS students. The format emphasizes practical problem-solving skills by teaching both core statistical concepts, such as hypothesis testing, confidence intervals, bootstrap simulation, and power analysis, as well as computational methods to implement them. The goal of the course is to prepare students for more advanced coursework, as well as self-teaching during their research careers.
Bio5488 Genomics
This course is tailored for graduate students with a basic understanding of genomics who aim to deepen their expertise in advanced concepts and applications in the field. The curriculum covers a wide range of topics including the mapping and sequencing of genomes, the latest computational and experimental techniques for identifying genomic variants, and the study of epigenetic modifications such as DNA methylation and chromatin accessibility. Students will also delve into methods for inferring transcription factor binding sites and motifs. High-throughput techniques for ascribing function to DNA, RNA, and protein sequences, including single-cell RNA sequencing, whole-genome sequencing, massively parallel reporter assays, chromosome conformation capture (Hi-C) analysis, metagenomics, and proteogenomic, will also be discussed. Finally, the use of genomic techniques and resources for studies of human disease will be addressed.
Bioinformaticist
Wang Lab
A subgroup of Dr. Ting Wang’s lab led by Dr. Daofeng Li in the Department of Genetics and The Edison Family Center for Genome Sciences and Systems Biology at Washington University School of Medicine is seeking a highly motivated Bioinformaticist to develop new data visualization techniques in the WashU Epigenome Browser platform.
We are looking for candidates with a strong background in bioinformatics, computational biology, and/or web development with excellent critical thinking, data management, and programming skills. Candidates must have experience in HTML, CSS and JavaScript/TypeScript. Full stack web development skills will be very beneficial.
This is a hybrid position with the flexibility of additional days on campus as needed for special projects. The Wang Lab is located is located in the Central West End of St. Louis, a vibrant neighborhood adjacent to major cultural institutions.
Cohen Lab
The genomics of gene regulation
PI: Barak Cohen, PhD
The Cohen Lab is interested in 1) Investigating DNA sequence features governing enhancer and cis-regulatory element activity. 2) Utilizing a multidisciplinary approach, blending genetics, genomics, biophysics, and computational sciences. 3) Aiming to develop quantitative models for identifying regulatory sequences, predicting mutation impacts, and enhancing our understanding of development and disease.
Cremins lab
Chromatin and spatial neurobiology
The Cremins lab investigates how the three-dimensional organization of the genome shapes brain development, neural function, and neurological disease. The lab studies how chromatin architecture and long-range genome interactions regulate gene expression, synaptic plasticity, and neural circuit function, and how disruptions in these processes contribute to disorders such as Alzheimer's disease, fragile X syndrome, and other neurodevelopmental and neurodegenerative diseases. By integrating genomics, genome engineering, advanced imaging, single-cell technologies, computational biology, and neuroscience, the Cremins Lab develops innovative tools to uncover how communication between chromatin and synapses influences memory, learning, and brain health.
Donald C. Shreffler Memorial Lecture
Shreffler Lecture
The Donald C. Shreffler lecture was established in 1995 through a generous gift from Mrs. Dorothy Shreffler and sons, Dave and Doug, to honor the contributions of Donald C. Shreffler, PhD to Washington University in St. Louis and the scientific community. This lecture historically has featured scientists whose work utilizes mouse as the model for genetic analysis and each year brings an eminent mouse geneticist to Washington University to speak in this lectureship.